Results 31 to 40 of about 3,726,105 (294)

CRISPR-Clear: A Fieldable Detection Procedure for Potential CRISPR-Cas9 Gene Drive Based Bioweapons [PDF]

, 2019
Rapid progression in genetic modification research has made gene editing increasingly cheaper and easier to use. CRISPR-Cas9 for example, allows for the specific alteration of the genome of an organism with relative simplicity and low costs.
Vittorio, Saggiomo, Angelina, Horsting, Aldrik, Velders, Jorrit W., Hegge, Martijn M., van Galen, Anna C., Nieuwenweg   +5 more
core   +2 more sources

Association of the AFF3 gene and IL2/IL21 gene region with juvenile idiopathic arthritis [PDF]

, 2010
Recent genetic studies have led to identification of numerous loci that are associated with susceptibility to autoimmune diseases. The strategy of using information from these studies has facilitated the identification of novel juvenile idiopathic ...
S Eyre, J Worthington, X Ke, P Martin, W Thomson, A Hinks, E Flynn, J Packham, A Barton, Martin, P., Barton, A., Gardner-Medwin, J. [CAPS and BSPAR study groups], UKRAG Consortium, Worthington, J., Thomson, W., Flynn, E., Packham, J., Hinks, A., British Society of Paediatric and Adolescent Rheumatology (BSPAR) Study Group, Eyre, S., Ke, X., Childhood Arthritis Prospective Study (CAPS)   +21 more
core   +1 more source

Immunization with the SDPM1 peptide lowers amyloid plaque burden and improves cognitive function in the APPswePSEN1(A246E) transgenic mouse model of Alzheimer's disease

Neurobiology of Disease, 2010
Vaccination has become an important therapeutic approach to the treatment of Alzheimer's disease (AD), however, immunization with Aβ amyloid can have unwanted, potentially lethal, side effects.
Chiou-Miin Wang, Sarah deVries, Marybeth Camboni, Matthew Glass, Paul T. Martin   +4 more
doaj   +1 more source

Update on Viral Gene Therapy Clinical Trials for Retinal Diseases [PDF]

, 2022
In 2001, the first large animal was successfully treated with a gene therapy that restored its vision. Lancelot, the Briard dog that was treated, suffered from a human childhood blindness called Leber's congenital amaurosis type 2.
Cheng, Shun-Yun, Punzo, Claudio
core   +1 more source

Kinase activity is required for the toxic effects of mutant LRRK2/dardarin

Neurobiology of Disease, 2006
Mutations in the LRRK2 gene, coding for dardarin, cause dominantly inherited Parkinson's disease (PD). Dardarin is a large protein, and mutations are found throughout the gene including the kinase domain.
Elisa Greggio, Shushant Jain, Ann Kingsbury, Rina Bandopadhyay, Patrick Lewis, Alice Kaganovich, Marcel P. van der Brug, Alexandra Beilina, Jeff Blackinton, Kelly Jean Thomas, Rili Ahmad, David W. Miller, Sashi Kesavapany, Andrew Singleton, Andrew Lees, Robert J. Harvey, Kirsten Harvey, Mark R. Cookson   +17 more
doaj   +1 more source

Meiotic drive and evolution of female choice [PDF]

, 1999
Reinhold K, Engqvist L, Misof B, Kurtz J. Meiotic drive and evolution of female choice. Proceedings of the Royal Society B. 1999;266(1426):1341-1345.As a special version of the good-genes hypothesis, it was recently proposed that females could benefit ...
Reinhold, Klaus, L. Engqvist, K. Reinhold, Misof, B., Engqvist, L., Reinhold, K., J. Kurtz, Engqvist, Leif ; https://orcid.org/, Misof, Bernhard, Kurtz, J., Kurtz, Joachim, B. Misof   +11 more
core   +1 more source

The impact of local population genetic background on the spread of the selfish element Medea‐1 in red flour beetles

Ecology and Evolution, 2020
Selfish genetic elements have been found in the genomes of many species, yet our understanding of their evolutionary dynamics is only partially understood.
Sarah A. Cash, Michael A. Robert, Marcé D. Lorenzen, Fred Gould   +3 more
doaj   +1 more source

A confinable home-and-rescue gene drive for population modification

eLife, 2021
Homing-based gene drives, engineered using CRISPR/Cas9, have been proposed to spread desirable genes throughout populations. However, invasion of such drives can be hindered by the accumulation of resistant alleles.
Nikolay P Kandul, Junru Liu, Jared B Bennett, John M Marshall, Omar S Akbari   +4 more
doaj   +1 more source

Genetic Approaches for Controlling CRISPR-based Autonomous Homing Gene Drives

Frontiers in Bioengineering and Biotechnology, 2022
CRISPR-based autonomous homing gene drives are a potentially transformative technology with the power to reduce the prevalence of, or even eliminate, vector-borne diseases, agricultural pests, and invasive species.
Pratima R. Chennuri, Zach N. Adelman, Kevin M. Myles   +2 more
doaj   +1 more source

Benefits and risks of gene drives for invasive plant management - the case for common tansy

Frontiers in Agronomy, 2023
Invasive plants cause significant environmental and economic damage, but land managers have few control options. Common tansy (Tanacetum vulgare) is prevalent in many US states and is one of the most reported invasive plants in Minnesota.
Lori Croghan, Alan G. Smith, Matthew A. Tancos, Neil O. Anderson, Roger L. Becker   +4 more
doaj   +1 more source