Results 31 to 40 of about 519,971 (295)

Association of the CCR5 gene with juvenile idiopathic arthritis [PDF]

, 2010
The CC chemokine receptor 5 (CCR5) has been shown to be important in the recruitment of T-helper cells to the synovium, where they accumulate, drive the inflammatory process and the consequent synovitis and joint destruction.
Martin, P., BSPAR Study Group, Barton, A., UKRAG Consortium, Worthington, J., Gardner-Medwin, J. [CAPS and BSPAR Study Groups], Thomson, W., W Thomson, Flynn, E., A Hinks, E Flynn, J Packham, Packham, J., Hinks, A., S Eyre, J Worthington, Eyre, S.; id_orcid, Eyre, S., Barton, A.; id_orcid, P Martin, Childhood Arthritis Prospective Study (CAPS), Martin, P.; id_orcid, A Barton   +22 more
core   +1 more source

GGene drives in the U.K., U.S., and Australian press (2015–2019): How a new focus on responsibility is shaping science communication

, 2022
Gene drive is a controversial biotechnology for pest control. Despite a commitment from gene drive researchers to responsibility and the key role of the media in debates about science and technology, little research has been conducted on media reporting ...
Nerlich, Brigitte, Stelmach, Aleksandra, Hartley, Sarah   +2 more
core   +1 more source

Gene Drive Parameters.

, 2021
Gene Drive Parameters.
Samuel E. Champer (8567463), Pablo García-Díaz (3247677), Nathan Oakes (11886455), Philipp W. Messer (8567466), Ronin Sharma (11886458), Jackson Champer (4261381)   +5 more
core   +1 more source

An Isolated Limb Infusion Method Allows for Broad Distribution of rAAVrh74.MCK.GALGT2 to Leg Skeletal Muscles in the Rhesus Macaque

Molecular Therapy: Methods & Clinical Development, 2018
Recombinant adeno-associated virus (rAAV)rh74.MCK.GALGT2 is a muscle-specific gene therapy that is being developed to treat forms of muscular dystrophy.
Rui Xu, Ying Jia, Deborah A. Zygmunt, Megan L. Cramer, Kelly E. Crowe, Guohong Shao, Agatha E. Maki, Haley N. Guggenheim, Benjamin C. Hood, Danielle A. Griffin, Ellyn Peterson, Brad Bolon, John P. Cheatham, Sharon L. Cheatham, Kevin M. Flanigan, Louise R. Rodino-Klapac, Louis G. Chicoine, Paul T. Martin   +17 more
doaj   +1 more source

Gene drive systems: do they have a place in agricultural weed management? [PDF]

, 2018
There is a pressing need for novel control techniques in agricultural weed management. Direct genetic control of agricultural pests encompasses a range of techniques to introduce and spread novel, fitness-reducing genetic modifications through pest ...
Neve, P., Paul Neve
core   +1 more source

Immunization with the SDPM1 peptide lowers amyloid plaque burden and improves cognitive function in the APPswePSEN1(A246E) transgenic mouse model of Alzheimer's disease

Neurobiology of Disease, 2010
Vaccination has become an important therapeutic approach to the treatment of Alzheimer's disease (AD), however, immunization with Aβ amyloid can have unwanted, potentially lethal, side effects.
Chiou-Miin Wang, Sarah deVries, Marybeth Camboni, Matthew Glass, Paul T. Martin   +4 more
doaj   +1 more source

Kinase activity is required for the toxic effects of mutant LRRK2/dardarin

Neurobiology of Disease, 2006
Mutations in the LRRK2 gene, coding for dardarin, cause dominantly inherited Parkinson's disease (PD). Dardarin is a large protein, and mutations are found throughout the gene including the kinase domain.
Elisa Greggio, Shushant Jain, Ann Kingsbury, Rina Bandopadhyay, Patrick Lewis, Alice Kaganovich, Marcel P. van der Brug, Alexandra Beilina, Jeff Blackinton, Kelly Jean Thomas, Rili Ahmad, David W. Miller, Sashi Kesavapany, Andrew Singleton, Andrew Lees, Robert J. Harvey, Kirsten Harvey, Mark R. Cookson   +17 more
doaj   +1 more source

The impact of local population genetic background on the spread of the selfish element Medea‐1 in red flour beetles

Ecology and Evolution, 2020
Selfish genetic elements have been found in the genomes of many species, yet our understanding of their evolutionary dynamics is only partially understood.
Sarah A. Cash, Michael A. Robert, Marcé D. Lorenzen, Fred Gould   +3 more
doaj   +1 more source

A confinable home-and-rescue gene drive for population modification

eLife, 2021
Homing-based gene drives, engineered using CRISPR/Cas9, have been proposed to spread desirable genes throughout populations. However, invasion of such drives can be hindered by the accumulation of resistant alleles.
Nikolay P Kandul, Junru Liu, Jared B Bennett, John M Marshall, Omar S Akbari   +4 more
doaj   +1 more source

Gene drive: communication, hype, and the publics. [PDF]

J Med Entomol
Abstract Engineered gene drive (EGD) systems are probably the most high-tech approach considered for their potential role in the control of vector-borne diseases. Interestingly, the rhetoric around it often goes along with a negative presentation of the current “conventional” tools and exaggerated promises about EGD themselves, leading ...
Boëte C, Boëte C.
europepmc   +3 more sources