Results 51 to 60 of about 189,147 (282)

A New Approach to Develop Resistant Cultivars Against the Plant Pathogens: CRISPR Drives

Frontiers in Plant Science, 2022
CRISPR drive is a recent and robust tool that allows durable genetic manipulation of the pest population like human disease vectors such as malaria vector mosquitos.
Mumin Ibrahim Tek, Kubra Budak
doaj   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

BCMA-CD19 armored compound CAR T cells in systemic lupus erythematosus: extended follow-up of a phase 1 clinical trial

Journal of Hematology & Oncology
CD19 CAR T-cells have shown promise in treating systemic lupus erythematosus (SLE), however, relapses demonstrate persistently elevated autoantibodies characteristic of CD19-negative long-lived plasma cells (LLPCs).
Ming Hong, Mingxia Wang, Ronghao Zeng, Ling Ding, Shanzhi He, Ting Lan, Vincent M DeStefano, Masayuki Wada, Kevin Pinz, Jennifer E. Chow, Byeong Hyeok Choi, Nabil Hagag, Min Wang, Yu Ma, Jing Luo, Yingwen Liang, Shihao Ding, Ziji Lu, Wenli Zhang, Yupo Ma, Weijia Wang   +20 more
doaj   +1 more source

A Y-chromosome shredding gene drive for controlling pest vertebrate populations

eLife, 2019
Self-replicating gene drives that modify sex ratios or infer a fitness cost could be used to control populations of invasive alien species. The targeted deletion of Y sex chromosomes using CRISPR technology offers a new approach for sex bias that could ...
Thomas AA Prowse, Fatwa Adikusuma, Phillip Cassey, Paul Thomas, Joshua V Ross   +4 more
doaj   +1 more source

Scientifically framed gene drive communication perceived as credible but riskier

People and Nature, 2021
Humans have caused a catastrophic decline to animal species and look to emerging technologies to stop the decline. Gene drive is a potential tool that may eradicate invasive rodents known for their devastating impact on native animals.
Edith A. MacDonald, Eric D. Edwards, Jovana Balanovic, Fabien Medvecky   +3 more
doaj   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

In Our Image: The Ethics of CRISPR Genome Editing

Biomolecular Concepts, 2021
The advent of genome editing technology promises to transform human health, livestock and agriculture, and to eradicate pest species. This transformative power demands urgent scrutiny and resolution of the ethical conflicts attached to the creation and ...
Eissenberg Joel C.
doaj   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Tuning CRISPR-Cas9 Gene Drives in Saccharomyces cerevisiae

G3: Genes, Genomes, Genetics, 2018
Control of biological populations is an ongoing challenge in many fields, including agriculture, biodiversity, ecological preservation, pest control, and the spread of disease.
Emily Roggenkamp, Rachael M. Giersch, Madison N. Schrock, Emily Turnquist, Megan Halloran, Gregory C. Finnigan   +5 more
doaj   +1 more source