Results 81 to 90 of about 11,418,435 (287)
Regulation of alternative splicing in the rat fibronectin gene [PDF]
, 1994 Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, 1994.Includes bibliographical references (p.
Huh, Gene Simon
core
Modern AgricultureWe are facing significant agricultural and environmental challenges, including herbicide‐resistant weeds that compromise crop yields and invasive plant species that disrupt local ecosystems.
Yawen Liu, Bingke Jiao, Wenfeng Qian
doaj +1 more source
North American red fox rabies immunity gene drive for safer (sub)urban rewilding [PDF]
Research Ideas and OutcomesAnimal-transmitted diseases such as rabies represent a barrier to successful rewilding and threaten continued human-wildlife co-existence. In North America, population growth and human settlement expansion lead to encounters with wild mammals which have ...
Vixey Douglas
doaj +3 more sources
Discerning protein pools by selective staining with self‐labeling tags
FEBS Letters, EarlyView.Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley +1 more source
Meiotic drive and evolution of female choice [PDF]
, 1999 Reinhold K, Engqvist L, Misof B, Kurtz J. Meiotic drive and evolution of female choice. Proceedings of the Royal Society B. 1999;266(1426):1341-1345.As a special version of the good-genes hypothesis, it was recently proposed that females could benefit ...
Reinhold, Klaus +11 more
core +1 more source
Steps Towards a Precautionary Risk Governance of SPAGE Technologies Including Gene-Drives [PDF]
, 2020 In view of the rapid dynamics of genetic engineering development (in particular regarding the ‘new gene-technologies’ gene editing, self-propagating artificial genetic elements (SPAGE) and synthetic biology), the question is being intensively discussed whether the currently practiced risk governance is sufficient to guarantee the desired high level of ...
openaire +1 more source
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
BMC Biology, 2020 Background Gene drives based on CRISPR-Cas9 technology are increasingly being considered as tools for reducing the capacity of mosquito populations to transmit malaria, and one of the most promising options is driving endonuclease genes that reduce the ...
Ace R. North +2 more
doaj +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source