Results 201 to 210 of about 7,215,457 (388)

Opsin gene duplication in Lepidoptera: retrotransposition, sex linkage, and gene expression [PDF]

Mol Biol Evol, 2023
Mulhair PO, Crowley L, Boyes DH, Lewis OT, Holland PW.   +4 more
europepmc   +2 more sources

Glycan‐Mediated Grafting of Extracellular Matrix Proteins for Stable Biofunctionalization of Polystyrene Surfaces

Advanced Materials Interfaces, EarlyView.
We present a glycan‐mediated strategy for covalent grafting of extracellular matrix proteins onto polystyrene surfaces. This approach preserves protein bioactivity and enhances cell adhesion and viability. Using fibronectin and vitronectin, we demonstrate stable immobilization via glycosylation sites, offering a promising route for advanced ...
Mathilde Hindié, Damien Seyer, Ousmane Ba, Anthony C. Duncan, Arnaud Ponche, Olivier Gallet, Karine Anselme   +6 more
wiley   +1 more source

Engineering of an Ancestral McbA with Enhanced Domain Mobility Extends Biocatalytic Amide Synthesis Scope

Advanced Synthesis &Catalysis, EarlyView.
We show how engineered ancestral amide bond synthetases (ABSs) together with cofactor recycling using a single polyphosphate kinase paves the way for chemoenzymatic synthesis of pharmacophores. The figure illustrates how ancestral ABS has a more flexible C‐terminal domain, which is associated with enhanced catalytic performance and expanded amine scope.
Elisabeth Söderberg, Marianne R. Molenaar, Katarzyna Zaczyk, Magnus Johansson, Martin A. Hayes, Per‐Olof Syrén   +5 more
wiley   +1 more source

Structural Characterization and AI‐Enhanced Modeling of a Broadly Neutralizing Camelid Antibody Against SARS‐CoV‐2 Variants

Advanced Therapeutics, EarlyView.
This study characterizes a camelid antibody (B10) with potent neutralizing activity against SARS‐CoV‐2 Wildtype and Omicron variants. Through binding assays, epitope mapping, pseudovirus neutralization, and AI‐driven modeling, the antibody is shown to target conserved RBD regions in a closed Spike conformation.
Katja Hanack, Urszula Orzeł, Anja Schlör, Sourabh Mehta, Anandi Krishnan, Slawomir Filipek, Rushika Patel, Madhvi Joshi, Markus Hoffmann, Stefan Pöhlmann, Chaitanya Joshi, Dorian Liepmann, Ramasamy Paulmurugan, Venkatesan Renugopalakrishnan   +13 more
wiley   +1 more source

NNMT Orchestrates Metabolic‐Epigenetic Reprogramming to Drive Macrophage‐Myofibroblast Transition in Hypertrophic Scarring

Advanced Science, EarlyView.
In macrophage‐myofibroblast transition, upregulated NNMT depletes S‐Adenosylmethionine‌ (SAM) and nicotinamide adenine dinucleotide(NAD+), thereby triggering epigenetic reprogramming via Histone H3 Lysine 27 acetylation (H3K27ac) accumulation at the promoter region of master transcription factor Prrx1.
Xiwen Dong, Weinan Guo, Yuxuan Qian, Wenyan Jin, Xiaozhen Li, Jingyuan Yang, Qingrong Ni, Shuang Wu, Fanni Li, Hua Wang, Chunying Li, Hong Cai   +11 more
wiley   +1 more source

PHR‐Mediated Pi Starvation Response Mobile Messenger RNAs Represent Noncoding Transcripts in Recipient Tissues

Advanced Science, EarlyView.
Mobile messenger RNAs (mRNAs) can travel long distances, serving as systemic signals that participate in plant growth and stress acclimation. This work determines that PHR proteins mediate the Pi starvation response (PSR)‐specific long‐distance transport of mRNAs and that these PSR‐specific mobile mRNAs represent noncoding transcripts in recipient ...
Weiguo Dong, Shuman Wang, Chao Liu, Lulu Qiao, Kai Liu, Qiongli Jin, Xiaorong Mo, Xingxing Shen, Keke Yi, Zhiye Wang   +9 more
wiley   +1 more source

Gene Duplication, Translocation, and Molecular Evolution of <i>Dmrt1</i> and Related Sex-Determining Genes in Anurans. [PDF]

Biomolecules
Shinde SS, Veltsos P, Ma WJ.
europepmc   +1 more source

An ancient genome duplication contributed to the abundance of metabolic genes in the moss -1

, 2011
A Rensing Stefan, Julia Ick, Andrea Jeffrey, Daniel Lang, Zimmer Andreas, Van de Peer Yves, Reski Ralf   +6 more
openalex   +1 more source

FcγRIIIB Gene Duplication: Evidence for Presence and Expression of Three Distinct FcγRIIIB Genes in NA(1+,2+)SH(+) Individuals [PDF]

, 1998
Harry R. Koene, Marion Kleijer, Dirk Roos, Masja de Haas, A. E. G. Kr. von dem Borne   +4 more
openalex   +1 more source

Additional file 1 of Evolution of the CBL and CIPK gene families in Medicago: genome-wide characterization, pervasive duplication, and expression pattern under salt and drought stress

, 2022
Xiaoxia Zhang, Xiaolong Ren, Xiaotong Qi, Zhimin Yang, Xiaolei Feng, Tian Zhang, Huijie Wang, Liang Peng, Qiying Jiang, Wenjun Yang, Yuan Fu, Min Chen, Zhixi Fu, Bo Xu   +13 more
openalex   +1 more source