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Advanced Science, EarlyView.DSBs are the most critical genomic lesions. Using the ChromInSight framework, It is revealed that 3D chromatin structure, rather than linear distance, shapes cluster‐scene between hub‐Nodes and DSB loci. The “spatial isolation–damage containment” hypothesis is proposed to illustrate how the genome responds to genomic damage and offer a powerful tool ...
Kang Xu +9 more
wiley +1 more source
Advanced Science, EarlyView.FM‐DEL1 and FM‐DEL2 are constructed by installing one or two sets of building blocks on a phenylalanine central scaffold. FM‐DELs are screened against markers of prostate, and renal cell carcinoma, and against an immunological target expressed on the surface of natural killer cells.
Francesca Migliorini +12 more
wiley +1 more source
Evolution of the RALF Gene Family in Plants: Gene Duplication and Selection Patterns
Evolutionary Bioinformatics, 2012 Jun Cao, Feng Shi
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Duplications in theDMD gene [PDF]
Human Mutation, 2006 The detection of duplications in Duchenne (DMD)/Becker Muscular Dystrophy (BMD) has long been a neglected issue. However, recent technological advancements have significantly simplified screening for such rearrangements. We report here the detection and analysis of 118 duplications in the DMD gene of DMD/BMD patients.
A.L.J. Kneppers +9 more
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Retention of duplicated genes in evolution
Trends in Genetics, 2022Gene duplication is a prevalent phenomenon across the tree of life. The processes that lead to the retention of duplicated genes are not well understood. Functional genomics approaches in model organisms, such as yeast, provide useful tools to test the mechanisms underlying retention with functional redundancy and divergence of duplicated genes ...
John S. Taylor +2 more
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Duplication of haemoglobin genes
Biochimie, 1972Resume L'etude de l'hemoglobine humaine a ete particulierement fructueuse dans la definition des genes de structure. La reconnaissance du fait que plus d'un locus peut intervenir dans le controle genetique d'une chaine polypeptidique a conduit a reexaminer certaines idees generalement acceptees.
Robert D. Koler +2 more
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Gene Duplication and Evolution
Science, 2001Lynch and Conery ([1][1]) presented one of the first serious efforts to study the evolutionary fate of gene duplication using genomic sequence data. Their analysis led to several interesting observations, particularly with respect to the rate of gene duplication in eukaryotic genomes and ...
Kevin R. Thornton, Manyuan Long
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, 2010 Due the sheer size and complexity of genomes, it is essential to develop automated methods to analyze them. To compare genomes, one distance measure that has been proposed is to determine the minimum number of evolutionary changes needed to transform one genome into another.
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Gene Duplication and Evolution
Science, 2002Abstract Motivated in part by Ohno’s (1970) influential book, substantial attention has been given to the idea that gene duplication is a major mechanism for the origin of new gene functions. A theoretical population genetic framework for understanding the evolutionary mechanisms responsible for the success versus demise of gene ...
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