Results 331 to 340 of about 7,565,225 (388)
Some of the next articles are maybe not open access.
Gene Duplication and Gene Loading
2014During the early evolution of life, gene duplication, the production of two copies of a DNA sequence, allowed the rapid diversification of enzymatically catalyzed reactions and an increase in genome size, providing also material for the invention of new enzymatic properties and complex regulatory and developmental patterns. A duplication may involve (i)
openaire +2 more sources
Gene Duplication and Evolution
Science, 2002Abstract Motivated in part by Ohno’s (1970) influential book, substantial attention has been given to the idea that gene duplication is a major mechanism for the origin of new gene functions. A theoretical population genetic framework for understanding the evolutionary mechanisms responsible for the success versus demise of gene ...
openaire +1 more source
Current Opinion in Genetics & Development, 2001
Genomic sequencing projects have revealed the productivity of processes duplicating genes or entire chromosome segments. Substantial proportions of the yeast, Arabidopsis and human gene complements are made up of duplicates. This has prompted much interest in the processes of duplication, functional divergence and loss of genes, has renewed the debate ...
openaire +2 more sources
Genomic sequencing projects have revealed the productivity of processes duplicating genes or entire chromosome segments. Substantial proportions of the yeast, Arabidopsis and human gene complements are made up of duplicates. This has prompted much interest in the processes of duplication, functional divergence and loss of genes, has renewed the debate ...
openaire +2 more sources
Analysing gene function after duplication
BioEssays, 2001AbstractAfter gene duplication, mutations cause the gene copies to diverge. The classical model predicts that these mutations will generally lead to the loss of function of one gene copy; rarely, new functions will be created and both duplicate genes are conserved.
T, Massingham, L J, Davies, P, Liò
openaire +2 more sources
Expression divergence between duplicate genes
Trends in Genetics, 2005A general picture of the role of expression divergence in the evolution of duplicate genes is emerging, thanks to the availability of completely sequenced genomes and functional genomic data, such as microarray data. It is now clear that expression divergence, regulatory-motif divergence and coding-sequence divergence all increase with the age of ...
Wen-Hsiung, Li, Jing, Yang, Xun, Gu
openaire +2 more sources
Venom evolution through gene duplications
Gene, 2012Venoms contain highly complex mixtures that typically include hundreds of different components and have evolved independently in a diverse range of animals including platypuses, shrews, snakes, lizards, fishes, echinoderms, spiders, wasps, centipedes, sea snails, cephalopods, jellyfish and sea anemones. Many venom genes evolved through gene duplication.
Wong, Emily S. W., Belov, Katherine
openaire +3 more sources
Horizontal gene transfers as metagenomic gene duplications
Molecular BioSystems, 2012While it is well accepted that horizontal gene transfer plays an important role in the evolution and the diversification of prokaryotic genomes, many questions remain open regarding its functional mechanisms of action and its interplay with the extant genome.
Grassi L +3 more
openaire +3 more sources
Zinc finger gene clusters and tandem gene duplication
Proceedings of the fifth annual international conference on Computational biology, 2001Zinc finger genes in mammalian genomes are frequently found to occur in clusters with cluster members appearing in a tandem array on the chromosome. It has been suggested that in situ gene duplication events are primarily responsible for the evolution of such clusters.
Mengxiang, Tang +2 more
openaire +2 more sources
Seminars in Cell & Developmental Biology, 1999
The study of Hox gene clusters continues to serve as a paradigm for those interested in vertebrate genome evolution. Recent exciting discoveries about Hox gene composition in fishes challenges conventional views about vertebrate Hox gene evolution, and has initiated lively debates concerning the evolutionary events making the divergence of the major ...
openaire +2 more sources
The study of Hox gene clusters continues to serve as a paradigm for those interested in vertebrate genome evolution. Recent exciting discoveries about Hox gene composition in fishes challenges conventional views about vertebrate Hox gene evolution, and has initiated lively debates concerning the evolutionary events making the divergence of the major ...
openaire +2 more sources
Gene duplication in glutathione reductase
Journal of Molecular Biology, 1980Abstract The two nucleotide-binding domains of the flavo-enzyme glutathione reductase have similar chain folds. In order to evaluate whether the observed similarity is significant or not, a mean distance between both chains after best overlay was calculated. Insertions and deletions were taken into account. The significance of the observed similarity
openaire +3 more sources