Results 341 to 350 of about 6,833,475 (368)
Some of the next articles are maybe not open access.
16 The evolution of gene duplicates
2002Gene and genome duplications have given rise to enormous variability among species in the number of genes within their genomes. Gene copies have in turn played important roles in adaptation, having been implicated in the evolution of the immune response, insecticide resistance, efficient protein synthesis, and vertebrate body plans. In this chapter, we
Paul J. Yong, Sarah P. Otto
openaire +3 more sources
Duplicated homeobox genes in Xenopus
Developmental Biology, 1989Multiple kinds of clones and restriction fragment polymorphisms are frequently encountered when analyzing genes of the tetraploid frog Xenopus laevis. Two types of cDNA clone have been isolated for homeobox gene 2. Analysis of their corresponding genomic clones confirmed the existence of clearly distinct restriction maps; in addition the nearby ...
Edward M. De Robertis +4 more
openaire +3 more sources
The evolutionary demography of duplicate genes [PDF]
, 2003 Although gene duplication has generally been viewed as a necessary source of material for the origin of evolutionary novelties, the rates of origin, loss, and preservation of gene duplicates are not well understood. Applying steady-state demographic techniques to the age distributions of duplicate genes censused in seven completely sequenced genomes ...
Michael Lynch, John S. Conery
openaire +2 more sources
Current Opinion in Genetics & Development, 2001
Genomic sequencing projects have revealed the productivity of processes duplicating genes or entire chromosome segments. Substantial proportions of the yeast, Arabidopsis and human gene complements are made up of duplicates. This has prompted much interest in the processes of duplication, functional divergence and loss of genes, has renewed the debate ...
openaire +3 more sources
Genomic sequencing projects have revealed the productivity of processes duplicating genes or entire chromosome segments. Substantial proportions of the yeast, Arabidopsis and human gene complements are made up of duplicates. This has prompted much interest in the processes of duplication, functional divergence and loss of genes, has renewed the debate ...
openaire +3 more sources
Gene Duplication and Gene Loading
2014During the early evolution of life, gene duplication, the production of two copies of a DNA sequence, allowed the rapid diversification of enzymatically catalyzed reactions and an increase in genome size, providing also material for the invention of new enzymatic properties and complex regulatory and developmental patterns. A duplication may involve (i)
openaire +3 more sources
Gene duplication in glutathione reductase
Journal of Molecular Biology, 1980Abstract The two nucleotide-binding domains of the flavo-enzyme glutathione reductase have similar chain folds. In order to evaluate whether the observed similarity is significant or not, a mean distance between both chains after best overlay was calculated. Insertions and deletions were taken into account. The significance of the observed similarity
openaire +4 more sources
Preservation of duplicate genes by originalization
Genetica, 2008Neofunctionalization, subfunctionalization and increasing gene dosage were proposed to be the possible ways to explain duplicate-gene preservation in previous studies. However, in some natural populations, such as yeast Saccharomyces cerevisiae, a considerable proportion of the duplicate genes originated from ancient whole genomic duplication (WGD) is ...
Cheng Xue, Yunxin Fu, Yunxin Fu
openaire +3 more sources
Gene Duplication and the Evolution of Enzymes
Nature, 1968The relationship between structure and function of proteins makes it unlikely that a new enzyme activity can evolve unless the genome contains extra DNA with suitable coding properties such as is provided by the duplication of a gene for a functionally related enzyme.
R. L. Watts, David C. Watts
openaire +3 more sources
Horizontal gene transfers as metagenomic gene duplications
Molecular BioSystems, 2012While it is well accepted that horizontal gene transfer plays an important role in the evolution and the diversification of prokaryotic genomes, many questions remain open regarding its functional mechanisms of action and its interplay with the extant genome.
Marco Cosentino Lagomarsino +4 more
openaire +3 more sources
Evidence for gene duplication in collagen
Journal of Molecular Biology, 1976The amino acid sequence of collagen α 1 chain has been compared with itself at various displacements to search for systematic and significant repeats. It shows regularities at intervals related to the stagger between adjacent triple-helical molecules in the fibril, at a distance D of 670 A or 78 (Gly-X-Y) triplets.
openaire +3 more sources