Results 341 to 350 of about 7,215,457 (388)

Evidence for gene duplication in collagen

Journal of Molecular Biology, 1976
The amino acid sequence of collagen α 1 chain has been compared with itself at various displacements to search for systematic and significant repeats. It shows regularities at intervals related to the stagger between adjacent triple-helical molecules in the fibril, at a distance D of 670 A or 78 (Gly-X-Y) triplets.
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Gene Duplication and the Evolution of Enzymes

Nature, 1968
The relationship between structure and function of proteins makes it unlikely that a new enzyme activity can evolve unless the genome contains extra DNA with suitable coding properties such as is provided by the duplication of a gene for a functionally related enzyme.
R L, Watts, D C, Watts
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Detection of gene duplications and block duplications in eukaryotic genomes

Journal of Structural and Functional Genomics, 2003
Several eukaryotic genomes have been completely sequenced and this provides an opportunity to investigate the extent and characteristics (e.g., single gene duplication, block duplication, etc.) of gene duplication in a genome. Detecting duplicate genes in a genome, however, is not a simple problem because of several complications such as domain ...
Wen-Hsiung, Li, Zhenglong, Gu, Andre R O, Cavalcanti, Anton, Nekrutenko   +3 more
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On Gene Duplication

2013
Due the sheer size and complexity of genomes, it is essential to develop automated methods to analyze them. To compare genomes, one distance measure that has been proposed is to determine the minimum number of evolutionary changes needed to transform one genome into another.
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Horizontal gene transfers as metagenomic gene duplications

Molecular BioSystems, 2012
While it is well accepted that horizontal gene transfer plays an important role in the evolution and the diversification of prokaryotic genomes, many questions remain open regarding its functional mechanisms of action and its interplay with the extant genome.
Grassi L, CASELLE, Michele, Lercher MJ, Lagomarsino M.C.   +3 more
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Hox gene duplication in fish

Seminars in Cell & Developmental Biology, 1999
The study of Hox gene clusters continues to serve as a paradigm for those interested in vertebrate genome evolution. Recent exciting discoveries about Hox gene composition in fishes challenges conventional views about vertebrate Hox gene evolution, and has initiated lively debates concerning the evolutionary events making the divergence of the major ...
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Gene duplication in glutathione reductase

Journal of Molecular Biology, 1980
Abstract The two nucleotide-binding domains of the flavo-enzyme glutathione reductase have similar chain folds. In order to evaluate whether the observed similarity is significant or not, a mean distance between both chains after best overlay was calculated. Insertions and deletions were taken into account. The significance of the observed similarity
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Role of gene duplication in evolution

Genome, 1989
It is now known that many multigene and supergene families exist in eukaryote genomes: multigene families with uniform copy members like genes for ribosomal RNA, those with variable members like immunoglobulin genes, and supergene families such as those for various growth factor and hormone receptors.
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Gene function, gene networks and the fate of duplicated genes

Seminars in Cell & Developmental Biology, 1999
For both copies of a duplicated gene to become fixed in a population and subsequently maintained, selection must favour individuals with both genes over individuals with one. Here I review and assess some of the proposed ways that gene structure and function might affect the likelihood of both copies acquiring distinct functions and therefore positive ...
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Cancer epigenetics in clinical practice

Ca-A Cancer Journal for Clinicians, 2023
Veronica Davalos, Manel Esteller
exaly