Results 211 to 220 of about 8,339,405 (403)

Vascular Tissue Engineering: Advanced Techniques and Gene Editing in Stem Cells for Graft Generation [PDF]

, 2020
Sin-Guang Chen, Felix Nnaemeka Ugwu, Wan‐Chun Li, Noel M. Caplice, Eugen Petcu, Shea Ping Yip, Chien‐Ling Huang   +6 more
openalex   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

PP 6.3 – 00178 Targeting the human and macaque CCR5 genes using the CRISPR-SaCas9 gene-editing platform

Journal of Virus Eradication, 2022
M. Caocci, T. Burdo, R. Kaminski, P. Mancuso   +3 more
doaj   +1 more source

Redox regulation meets metabolism: targeting PRDX2 to prevent hepatocellular carcinoma

Molecular Oncology, EarlyView.
PRDX2 acts as a central redox hub linking metabolic dysfunction‐associated steatohepatitis (MASH) to hepatocellular carcinoma (HCC). In normal hepatocytes, PRDX2 maintains redox balance and metabolic homeostasis under oxidative stress. In contrast, during malignant transformation, PRDX2 promotes oncogenic signaling, stemness, and tumor initiation ...
Naroa Goikoetxea‐Usandizaga, María Luz Martinez‐Chantar, Carolina Conter   +2 more
wiley   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Near infrared light controlled gene editing. [PDF]

Light Sci Appl
Berezin MY.
europepmc   +1 more source

CRISPR-Cas9 Mediated Gene Editing: A Revolution in Genome Engineering [PDF]

, 2017
Shilpa Sampathi, P Horvath, R Barrangou, J Garneau, M Dupuis, M Villion, D Romero, R Barrangou, Le Cong, F, Ann Ran, David Cox, Shuailiang Lin, Robert Barretto, W Jiang, D Bikard, D Cox, F Zhang, L Marraffini, H Yang, H Wang, C Shivalila, A Cheng, L Shi, J Sander, J Joung, P Mali, K Esvelt, G Church, P Hsu, D Scott, J Weinstein, F Ran, S Konermann, F Ran, P Hsu, C Lin, J Gootenberg, S Konermann, J Kim, D Kim, S Kim, J Kim, I Lokody, Vikram Pattanayak, Steven Lin, John Guilinger, Enbo Ma, Jennifer Doudna, Abba Malina, John Mills, Regina Cencic, Yifei Yan, James Fraser, A Xiao, Z Wang, Y Hu, Y Wu, Z Luo, G Amitai, R Sorek, M Bolukbasi, A Gupta, S Wolfe, T Auer, K Duroure, A De Cian, J Concordet, Del Bene, F, R Deans, D Morgens, A kesli, S Pillay, M Horlbeck, D Du, L Qi, Y Guo, Q Xu, D Canzio, J Shou, J Li   +81 more
openalex   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Therapeutic applications of CRISPR-Cas9 gene editing. [PDF]

Front Genome Ed
Bharti A, Mudge J.
europepmc   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source