Results 231 to 240 of about 3,565,977 (300)

Threonine 348 regulates the subcellular localization of PTEN

FEBS Open Bio, EarlyView.
Thr348 in the C2 domain is a key contributor to PTEN subcellular localization. The PTEN350 fragment and PTENA4 accumulated in the nucleus, whereas PTENK13R,A4 predominantly localized to the plasma membrane. In contrast, substitution of Thr348 with Asp (T348D) disrupted these characteristic localization patterns, resulting in predominant cytoplasmic ...
Takashi Kato, Suzu Tanaka, Miyu Ohashi
wiley   +1 more source

Corrigendum to: Lipid nanoparticle formulation for gene editing and RNA-based therapies for glioblastoma. [PDF]

Neuro Oncol
europepmc   +1 more source

Establishing efficient multi-gene editing tools for papaya. [PDF]

Hortic Res
Wang B, Cao X, Lin Z, Zhuang Y, Yang G, Zhu JK, Ming R, Yue J.   +7 more
europepmc   +1 more source

Salmonella enterica serovar typhi limits the potency of typhoid toxin and ADP‐ribosylating toxin AB to establish a persistent infection

FEBS Open Bio, EarlyView.
The two catalytic subunits of typhoid toxin dissociate from the holotoxin in the ER of an intoxicated cell, but only CdtB exits the ER to generate immunosuppressive effects. PltA is retained in the ER and sequestered from its cytosolic target, thus allowing the anti‐inflammatory effects of CdtB to promote intestinal colonization.
Maria C. Zabala‐Rodriguez, Juliette K. Tinker, Teresa Frisan, Taj Azarian, Ken Teter   +4 more
wiley   +1 more source

Emerging therapies for type 1 diabetes: Immunotherapy and gene editing advances. [PDF]

J Int Med Res
Zhao M, Yao Z.
europepmc   +1 more source

A minimal cellulosome‐like system in Cellulosilyticum lentocellum

FEBS Open Bio, EarlyView.
Cellulose‐degrading bacteria typically use cellulosomes, large multi‐enzyme complexes on a scaffold protein. In Cellulosilyticum lentocellum, we characterise a far smaller arrangement, a single scaffold bound to one cellulase through a single cohesin‐dockerin interaction.
John Allan, Amias Alstrom‐Moore, Gary W Black   +2 more
wiley   +1 more source

Extrahepatic Gene Editing In Vivo Using Organic Solvent-Free Lipid Nanoparticles. [PDF]

Small
Streiber M, Liu N, Simon L, Adermann F, Bachmann V, Gath L, Hoeppener S, Schubert S, Werz O, Lapinte V, Morille M, Bauer M, Press AT, Schubert US, Traeger A.   +14 more
europepmc   +1 more source

Cell surface CD11c as a neutrophil aging marker molecule

FEBS Open Bio, EarlyView.
Cell surface CD11chi neutrophils were more aged and had better phagocytic function than CD11c−/lo neutrophils. Transcriptomic analysis of CD11chi neutrophils and CD11c−/lo neutrophils in pediatric population showed that the most difference was seen in infants.
Sophia Koutsogiannaki, Fahd Alhamdan, Erik Malm, Marie Bermudez, Samuel Y. Kim, Koichi Yuki   +5 more
wiley   +1 more source

Generation of a rhesus macaque harboring a multivalent reporter for assessing gene editing outcomes. [PDF]

Sci Rep
Ryu J, Ryder K, Naka H, Tran J, Hinrichs BJ, Biswas S, Rust LN, Yusova S, Dozier BL, Peterson SM, Wettengel JM, Hanna CB, Hennebold JD, Burwitz BJ, Bimber BN.   +14 more
europepmc   +1 more source

BCG vaccination potentiates oxidative phosphorylation in neonatal myeloid‐derived suppressor cells

FEBS Open Bio, EarlyView.
BCG vaccination enhances oxidative phosphorylation in neonatal MDSCs, impairing their immunosuppressive function. It upregulates electron transport chain genes and mitochondrial activity, increasing ATP and oxygen consumption. Pharmacological OXPHOS inhibition partially restores suppressive capacity, confirming causality.
Yingying Chen, Hui Li
wiley   +1 more source