Results 251 to 260 of about 8,657,992 (314)

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source

Correction: Hepatic targeting in ASCVD: integrating lipid lowering and inflammation modulation from statins to gene editing. [PDF]

J Transl Med
Xiao Q, Wang M, Wang S, Wang L, Ding H.
europepmc   +1 more source

Prognostic Impact of European LeukemiaNet Genetic Risk Stratification System in Adult Patients With Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
This study aimed to evaluate the prognostic value of ELN2017 in predicting survival outcomes and to assess the impact of clinical and molecular factors such as age, FLT3 and NPM1 mutations, and allogeneic hematopoietic stem cell transplantation (allo‐HSCT).
Mobina Shrestha, Bishwas Mandal, Vishal Mandal, Asis Shrestha, Amir Babu Shrestha   +4 more
wiley   +1 more source

Multiplex gene editing suppresses random integration of hepatitis B virus DNA in chronically infected liver. [PDF]

Mol Ther Nucleic Acids
Slattery S, Huo W, Arif A, Gordon J, Takeuchi R.   +4 more
europepmc   +1 more source

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

Publisher Correction: CRISPR-GPT for agentic automation of gene-editing experiments. [PDF]

Nat Biomed Eng
Qu Y, Huang K, Yin M, Zhan K, Liu D, Yin D, Cousins HC, Johnson WA, Wang X, Shah M, Altman RB, Zhou D, Wang M, Cong L.   +13 more
europepmc   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Optimization of RNP-CRISPR for high-efficiency gene editing in mouse intestinal organoids. [PDF]

Mol Cell Biochem
Cao X, He Y, Guo H, Cao X, Zhang D, Lai Y, Yang W, Ma Z, Yu X, Wang L, Li D, Zeng Z.   +11 more
europepmc   +1 more source

Snail 3G: genomics, genetics, and gene-editing of <i>Biomphalaria glabrata</i>. [PDF]

Front Genet
Zhang SM.
europepmc   +1 more source

Gene Editing and AI: Revolutionizing Biotechnology for a Sustainable Future. [PDF]

Iran J Biotechnol
europepmc   +1 more source