Results 271 to 280 of about 8,657,992 (314)

Gene editing in tomatoes

Emerging Topics in Life Sciences, 2017
Tomato is an effective model plant species because it possesses the qualities necessary for genetic and functional studies, but is also a food crop making what is learned more translatable for crop improvement when compared with other non-food crop models.
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Injectable Microgels with Hybrid Exosomes of Chondrocyte‐Targeted FGF18 Gene‐Editing and Self‐Renewable Lubrication for Osteoarthritis Therapy

Advances in Materials
Abnormal silencing of fibroblast growth factor (FGF) signaling significantly contributes to joint dysplasia and osteoarthritis (OA); However, the clinical translation of FGF18‐based protein drugs is hindered by their short half‐life, low delivery ...
Manyu Chen, Yan Lu, Yuhan Liu, Quanying Liu, Siyan Deng, Yuan Liu, Xiaolin Cui, Jie Liang, Xingdong Zhang, Yujiang Fan, Qiguang Wang   +10 more
semanticscholar   +1 more source

Delivery of gene editing therapeutics

Nanomedicine: Nanotechnology, Biology and Medicine, 2023
For the past decades, gene editing demonstrated the potential to attenuate each of the root causes of genetic, infectious, immune, cancerous, and degenerative disorders. More recently, Clustered Regularly Interspaced Short Palindromic Repeats-CRISPR-associated protein 9 (CRISPR-Cas9) editing proved effective for editing genomic, cancerous, or microbial
Kevadiya, Bhavesh D., Islam, Farhana, Deol, Pallavi, Zaman, Lubaba A., Mosselhy, Dina A., Ashaduzzaman, Md, Bajwa, Neha, Routhu, Nanda Kishore, Singh, Preet Amol, Dawre, Shilpa, Vora, Lalitkumar K., Nahid, Sumaiya, Mathur, Deepali, Nayan, Mohammad Ullah, Baldi, Ashish, Kothari, Ramesh, Patel, Tapan A., Madan, Jitender, Gounani, Zahra, Bariwal, Jitender, Hettie, Kenneth S., Gendelman, Howard E.   +21 more
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Hypoxia-Responsive Gene Editing to Reduce Tumor Thermal Tolerance for Mild-Photothermal Therapy.

Angewandte Chemie, 2021
Near-infrared (NIR)-light-triggered photothermal therapy (PTT) is usually associated with an undesirable heating damage to normal organs nearby due to its high temperature (>50 o C) for available tumor ablation.
Xueqing Li, Yongchun Pan, Chao Chen, Yanfeng Gao, Xinli Liu, Kaiyong Yang, Xiaowei Luan, Dongtao Zhou, Fei Zeng, Xin Han, Yujun Song   +10 more
semanticscholar   +1 more source

Concepts and tools for gene editing

Reproduction, Fertility and Development, 2016
Gene editing is a relatively recent concept in the molecular biology field. Traditional genetic modifications in animals relied on a classical toolbox that, aside from some technical improvements and additions, remained unchanged for many years. Classical methods involved direct delivery of DNA sequences into embryos or the use of embryonic stem cells ...
Santiago, Josa, Davide, Seruggia, Almudena, Fernández, Lluis, Montoliu   +3 more
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Is Gene Editing Harmless? Two Arguments for Gene Editing

The American Journal of Bioethics, 2022
Julian Savulescu, Marcos Alonso
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A path to efficient gene editing

Nature Medicine, 2018
Signaling by the tumor-suppressor protein p53 antagonizes CRISPR–Cas9 gene editing of human pluripotent stem cells and immortalized human retinal pigment epithelial cells.
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Improving gene-editing nucleases

Nature Methods, 2012
A flurry of recent papers report refinements to the activity and the assembly of engineered nucleases.
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Gene Editing

Hematology/Oncology Clinics of North America, 2017
Dale Ando, Kathleen Meyer
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In vivo editing of lung stem cells for durable gene correction in mice

Science
In vivo genome correction holds promise for generating durable disease cures; yet, effective stem cell editing remains challenging. In this work, we demonstrate that optimized lung-targeting lipid nanoparticles (LNPs) enable high levels of genome editing
Yehui Sun, Sumanta Chatterjee, Xizhen Lian, Zachary Traylor, Sandhya R. Sattiraju, Yufen Xiao, Sean A. Dilliard, Yun-Chieh Sung, Minjeong Kim, Sang M. Lee, Stephen Moore, Xu Wang, Di Zhang, Shiying Wu, Pratima Basak, Jialu Wang, Jing Liu, Rachel J. Mann, David F. LePage, Weihong Jiang, S. Abid, M. Hennig, Anna Martinez, Brandon A. Wustman, David J. Lockhart, Raksha Jain, Ronald A. Conlon, Mitchell L. Drumm, C. Hodges, D. Siegwart   +29 more
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