Results 261 to 270 of about 8,657,992 (314)

Allelic value in gene regulation-implications for gene editing. [PDF]

Ann Bot
Moin M, Rai M, Tyagi W.
europepmc   +1 more source

CRISPR technology in ovarian cancer research: advances from gene editing to precision diagnosis and therapy. [PDF]

Transl Cancer Res
Zhang Y, Tan Y, Du Y, Xiang R, Liu Y.
europepmc   +1 more source

The visualizable and marker-free gene editing platform mediated by CRISPR/Cas9 in Coleophoma empetri. [PDF]

Appl Microbiol Biotechnol
Xie L, Men P, Zhou Y, Li J, Zhang X, Wang M, Huang X, Lu X.   +7 more
europepmc   +1 more source

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A DNA Origami-Based Gene Editing System for Efficient Gene Therapy in Vivo.

Angewandte Chemie, 2023
DNA nanostructures have played an important role in the development of novel drug delivery systems. Herein, we report a DNA origami-based CRISPR/Cas9 gene editing system for efficient gene therapy in vivo.
Wantao Tang, Ting Tong, Hong Wang, Xuehe Lu, Changping Yang, Yushuai Wu, Yuang Wang, Jianbing Liu, Baoquan Ding   +8 more
semanticscholar   +1 more source

Engineered Nanomaterials to Potentiate CRISPR/Cas9 Gene Editing for Cancer Therapy

Advances in Materials, 2023
Clustered regularly interspaced short palindromic repeats/associated protein 9 (CRISPR/Cas9) gene‐editing technology shows promise for manipulating single or multiple tumor‐associated genes and engineering immune cells to treat cancers.
Ke Yi, Huimin Kong, Yeh-Hsing Lao, Di Li, Rachel L. Mintz, T. Fang, Guojun Chen, Yu Tao, Mingqiang Li, Jianxun Ding   +9 more
semanticscholar   +1 more source

Lipid Nanoparticles for Delivery of CRISPR Gene Editing Components

Small Methods
Gene editing has emerged as a promising therapeutic option for treating genetic diseases. However, a central challenge in the field is the safe and efficient delivery of these large editing tools, especially in vivo.
Fan Wu, Nei Li, Yudian Xiao, Rohan Palanki, Hannah M. Yamagata, Michael J. Mitchell, Xuexiang Han   +6 more
semanticscholar   +1 more source

CRISPR-GPT for agentic automation of gene-editing experiments

Nature Biomedical Engineering
Performing effective gene-editing experiments requires a deep understanding of both the CRISPR technology and the biological system involved. Meanwhile, despite their versatility and promise, large language models (LLMs) often lack domain-specific ...
Yuanhao Qu, Kaixuan Huang, Ming Yin, Kanghong Zhan, Dyllan Liu, Di Yin, H. Cousins, William A. Johnson, Xiaotong Wang, Mihir M. Shah, R. Altman, Denny Zhou, Mengdi Wang, Le Cong   +13 more
semanticscholar   +1 more source

Gene Editing for CEP290-Associated Retinal Degeneration

New England Journal of Medicine
BACKGROUND CEP290-associated inherited retinal degeneration causes severe early-onset vision loss due to pathogenic variants in CEP290. EDIT-101 is a clustered regularly interspaced short palindromic repeats (CRISPR)–CRISPR-associated protein 9 (Cas9 ...
Eric A Pierce, Tomas Aleman, K. Jayasundera, Bright S. Ashimatey, Keunpyo Kim, A. Rashid, Michael C. Jaskolka, Rene L Myers, Byron L. Lam, S. Bailey, Jason I. Comander, A. Lauer, Albert M. Maguire, M. Pennesi   +13 more
semanticscholar   +1 more source