Results 241 to 250 of about 1,135,829 (304)

Stage- and tissue-specific gene editing using 4-OHT-inducible Cas9 in whole organism. [PDF]

J Cell Biol
Li Y, Zhang W, Wei Z, Li H, Liu X, Zheng T, Aziz T, Xing C, Meng A, Wu X.   +9 more
europepmc   +1 more source

Shared Genetic Effects and Antagonistic Pleiotropy Between Multiple Sclerosis and Common Cancers

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Epidemiologic studies have reported inconsistent altered cancer risk in individuals with multiple sclerosis (MS). Factors such as immune dysregulation, comorbidities, and disease‐modifying therapies may contribute to this variability.
Asli Buyukkurt, Marius Ygonia, Ali Manouchehrinia, Philippe Lefrançois, Ingrid Kockum, Adil Harroud   +5 more
wiley   +1 more source

Gene editing using gamma modified PNA: HBB gene as a model. [PDF]

J Genet Eng Biotechnol
Eltaweel N, Elkamah G, Elaraby N, Hassan I, Wassel A, Abdel-Aziz N, Amr K.   +6 more
europepmc   +1 more source

Predicting Loss of Ambulation in Limb Girdle Muscular Dystrophy R9

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Limb girdle muscular dystrophy type R9 (LGMDR9) results from biallelic variants in FKRP. There is limited data to predict loss of ambulation (LOA) among those with LGMDR9. Methods Participants in an ongoing dystroglycanopathy natural history study (NCT00313677) with FKRP variants who had achieved ambulation and were more than 3 ...
Chandra L. Miller, Lauren N. Coffey, Shelley R. H. Mockler, Katie M. Laubscher, Carrie M. Stephan, M. Bridget Zimmerman, Katherine D. Mathews   +6 more
wiley   +1 more source

AI-driven CRISPR screening: optimizing gene editing through automation and intelligent decision support. [PDF]

J Transl Med
Zhao Y, Li X, Du Y.
europepmc   +1 more source

Immune‐Driven Expression in Inclusion Body Myositis With T‐Cell Large Granular Lymphocytic Leukemia

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives T‐cell large granular lymphocytic leukemia (T‐LGLL), reported in up to 58% of inclusion body myositis (IBM) patients, is a rare leukemia of cytotoxic or less commonly helper T cells. The range of myopathies in T‐LGLL and the impact of coexisting T‐LGLL in IBM are not well understood. Our objectives are to investigate the spectrum of
Pannathat Soontrapa, Iago Pinal‐Fernandez, Pritikanta Paul, Michael P. Skolka, Margherita Milone, Min Shi, Mithun V. Shah, Maria Casal‐Dominguez, Katherine Pak, Andrew L. Mammen, Teerin Liewluck   +10 more
wiley   +1 more source

Multiplex Gene Editing and Effect Analysis of Yield, Fragrance, and Blast Resistance Genes in Rice. [PDF]

Genes (Basel)
Guan S, Han Y, Zhang J, Du Y, Chen Z, Miao C, Li J.   +6 more
europepmc   +1 more source

CRISPR gene editing of AtRING1 unravels a critical role of RAWUL domain in PRC1 repression of transcription. [PDF]

Plant J
Wang Q, Chen D, Berr A, Shen WH.
europepmc   +1 more source

Precision gene editing: The power of CRISPR-Cas in modern genetics. [PDF]

Mol Ther Nucleic Acids
Joo JH, Lee S, Kim KP.
europepmc   +1 more source