Results 211 to 220 of about 1,135,829 (304)

Dual Effect of <i>EZH2</i> Gene Editing with CRISPR/Cas9 in Lung Cancer. [PDF]

Biology (Basel)
Menezes JM, de Mello DC, Saito KC, Kimura ET, Fuziwara CS.   +4 more
europepmc   +1 more source

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source

Gene editing method

Implementation of the gene editing ...
openaire   +1 more source

Complex HBB gene editing outcomes revealed by a fluorescent reporter cell model. [PDF]

Mol Ther Nucleic Acids
Karsenty CL, Betancourth D, Cao M, Pham QK, Park SH, Bao G.   +5 more
europepmc   +1 more source

Prognostic Impact of European LeukemiaNet Genetic Risk Stratification System in Adult Patients With Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
This study aimed to evaluate the prognostic value of ELN2017 in predicting survival outcomes and to assess the impact of clinical and molecular factors such as age, FLT3 and NPM1 mutations, and allogeneic hematopoietic stem cell transplantation (allo‐HSCT).
Mobina Shrestha, Bishwas Mandal, Vishal Mandal, Asis Shrestha, Amir Babu Shrestha   +4 more
wiley   +1 more source

Comprehensive assessment of activity, specificity, and safety of hypercompact TnpB systems for gene editing. [PDF]

Genome Biol
Xin C, Xiang G, Cao S, Wang Y, Yuan S, Liu X, Huo Y, Sun J, Wan X, Liu D, Hong J, Hu J, Wang H.   +12 more
europepmc   +1 more source

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

Virus induced gene editing using potyviral vectors in Cas12a expressing plants. [PDF]

Hortic Res
Merwaiss F, García A, Rogo U, Querol-Martí I, García-Sogo B, de Paola C, Rodriguez-Rodriguez M, Pineda B, Moreno V, Vazquez-Vilar M, Orzáez D, Daròs JA.   +11 more
europepmc   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source