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Emerging Topics in Life Sciences, 2017
Tomato is an effective model plant species because it possesses the qualities necessary for genetic and functional studies, but is also a food crop making what is learned more translatable for crop improvement when compared with other non-food crop models.
Joyce Van Eck, Joyce Van Eck
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Tomato is an effective model plant species because it possesses the qualities necessary for genetic and functional studies, but is also a food crop making what is learned more translatable for crop improvement when compared with other non-food crop models.
Joyce Van Eck, Joyce Van Eck
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Certification for gene-edited forests [PDF]
Science, 2019 International ...
Strauss, Steven H. +14 more
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Hypoxia-Responsive Gene Editing to Reduce Tumor Thermal Tolerance for Mild-Photothermal Therapy.
Angewandte Chemie, 2021Near-infrared (NIR)-light-triggered photothermal therapy (PTT) is usually associated with an undesirable heating damage to normal organs nearby due to its high temperature (>50 o C) for available tumor ablation.
Xueqing Li +10 more
semanticscholar +1 more source
2014
Genome editing represents a group of newly developed capabilities that allow nucleotide-level targeting of genomic regions in a wide range of species. This chapter provides an overview of these technologies which open the possibility of creating directed mutations in virtually any location of the genome.
Carl A. Pinkert, David A. Dunn
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Genome editing represents a group of newly developed capabilities that allow nucleotide-level targeting of genomic regions in a wide range of species. This chapter provides an overview of these technologies which open the possibility of creating directed mutations in virtually any location of the genome.
Carl A. Pinkert, David A. Dunn
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Trends in Genetics, 2018
Smithies et al. (1985) and Jasin and colleagues (1994) provided proof of concept that homologous recombination (HR) could be applied to the treatment of human disease and that its efficiency could be improved by the induction of double-strand breaks (DSBs).
Bak, Rasmus O +2 more
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Smithies et al. (1985) and Jasin and colleagues (1994) provided proof of concept that homologous recombination (HR) could be applied to the treatment of human disease and that its efficiency could be improved by the induction of double-strand breaks (DSBs).
Bak, Rasmus O +2 more
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Hematology/Oncology Clinics of North America, 2017
The clinical application and regulatory strategy of genome editing for ex vivo cell therapy is derived from the intersection of two fields of study: viral vector gene therapy trials; and clinical trials with ex vivo purification and engraftment of CD34+ hematopoietic stem cells, T cells, and tumor cell vaccines.
Dale Ando, Kathleen Meyer
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The clinical application and regulatory strategy of genome editing for ex vivo cell therapy is derived from the intersection of two fields of study: viral vector gene therapy trials; and clinical trials with ex vivo purification and engraftment of CD34+ hematopoietic stem cells, T cells, and tumor cell vaccines.
Dale Ando, Kathleen Meyer
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Is Gene Editing Harmless? Two Arguments for Gene Editing
The American Journal of Bioethics, 2022Julian Savulescu, Marcos Alonso
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Concepts and tools for gene editing
Reproduction, Fertility and Development, 2017Gene editing is a relatively recent concept in the molecular biology field. Traditional genetic modifications in animals relied on a classical toolbox that, aside from some technical improvements and additions, remained unchanged for many years. Classical methods involved direct delivery of DNA sequences into embryos or the use of embryonic stem cells ...
Davide Seruggia +3 more
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The Public and the Gene-Editing Revolution
New England Journal of Medicine, 2016Polls conducted over recent decades give a sense of what the U.S. public thinks about gene therapy and gene editing in adults, children, and human embryos or germline cells, as well as of whether and for what reasons Americans would consider undergoing genetic testing.
John M. Benson +2 more
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Science, 2019
Biotechnology Genetically modified crops have supporters and opponents, but how can these views be reconciled to improve food security? This problem is particularly acute for middle-income countries that need to export crops to maintain their economy as well as provide for their expanding population. In a Perspective, Zaidi et al.
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Biotechnology Genetically modified crops have supporters and opponents, but how can these views be reconciled to improve food security? This problem is particularly acute for middle-income countries that need to export crops to maintain their economy as well as provide for their expanding population. In a Perspective, Zaidi et al.
openaire +2 more sources