Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Positive selection underlies Faster-Z evolution of gene expression in birds.
, 2015 The elevated rate of evolution for genes on sex chromosomes compared to autosomes (Fast-X or Fast-Z evolution) can result either from positive selection in the heterogametic sex, or from non-adaptive consequences of reduced relative effective population ...
Zimmer, F +4 more
core
Causal modelling of gene effects from regulators to programs to traits. [PDF]
NatureOta M +6 more
europepmc +1 more source
Comparison of metaheuristics to measure gene effects on phylogenetic supports and topologies. [PDF]
BMC Bioinformatics, 2018 Garnier R +5 more
europepmc +1 more source
Effects of bombesin on pancreatic digestive enzyme gene expression
, 1992 Stefan Rosewicz
openalex +1 more source
Specific Polymorphisms of IL-1β Genes (-511, +3953) and Their Probable Effects on IL-1β Production in Idiopatic Hypogonadotropic Hypogonadism [PDF]
, 2010 Uğur Muşabak +8 more
openalex +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Corrigendum: Knock-Down of the Phosphoserine Phosphatase Gene Effects Rather N- Than S-Metabolism in Arabidopsis thaliana. [PDF]
Front Plant Sci, 2019 Samuilov S +8 more
europepmc +1 more source
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Knock-Down of the Phosphoserine Phosphatase Gene Effects Rather N- Than S-Metabolism in Arabidopsis thaliana. [PDF]
Front Plant Sci, 2018 Samuilov S +8 more
europepmc +1 more source