Results 241 to 250 of about 2,669,754 (369)

[Effect of environmental chemicals on the genes and the gene expression].

Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 2010
Chemicals act on biological molecules and affect their functions. DNA is one of the most important targets, damaging of which could lead to diverse diseases including cancer. The mode of action of chemicals to DNA contains chemical reaction and protein factor-mediated modulation of the function.
openaire   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Effects of polymorphism in G2677T/A triallelic region of MDR1 gene in Turkish patients with inflammatory bowel disease

, 2008
Ayşegül Sapmaz, Senem Ceren Karatayli, Ülkü DAĞLI, Zeki Mesut Yalın Kılıç, Murat TÖRÜNER, Yasemin Çelik, Muhip Özkan, İrfan Soykan, H. ÇETİNKAYA, Aysel ÜLKER, Ali ÖZDEN, A. Mithat BOZDAYI   +11 more
openalex   +1 more source

Reconstructing mammalian lifespan evolution reveals strong phylogenetic effects and lifespan-associated genes

Zhen-Na Zhang, Xue Lyu, Shan-Zhuang Niu, Dongming Xu, Cheng-Gang Zou   +4 more
openalex   +1 more source

In vivo Exposure Effects of ^99mTc-methoxyisobutylisonitrile on the FDXR and XPA Genes Expression in Human Peripheral Blood Lymphocytes.

, 2018
Mohammad Taghi Bahreyni-Toossi, Habibeh Vosoughi, Hosein Azimian, Abdul Rahim Rezaei, Mehdi Momennezhad   +4 more
openalex   +2 more sources

BRCA1 Effects on the Cell Cycle and the DNA Damage Response Are Linked to Altered Gene Expression [PDF]

, 2000
Timothy K. MacLachlan, Kumaravel Somasundaram, Magda Sgagias, Yelena Shifman, Ruth J. Muschel, Kenneth H. Cowan, Wafik S. El‐Deiry   +6 more
openalex   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Physiological and metabolic effects of a transposon-mediated mutation in the glutamate synthase gene, gltB, of plant-beneficial, cytokinin-producing Pseudomonas hormoni G20-18T

Ajay M. Sorty, Athanasios Zervas, Vaidotas Kisielius, Chandana Pandey, Rosanna C. Hennessy, Tue Kjærgaard Nielsen, Pedro N. Carvalho, Thomas Roitsch, Peter Stougaard   +8 more
openalex   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source