Results 131 to 140 of about 5,552,491 (299)

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Genome-wide and single-cell analyses reveal a context dependent relationship between CBP recruitment and gene expression [PDF]

, 2014
Lawryn H. Kasper, Chunxu Qu, John C. Obenauer, Daniel McGoldrick, Paul K. Brindle   +4 more
openalex   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Detection of Growth Hormone Doping by Gene Expression Profiling of Peripheral Blood [PDF]

, 2009
Chris J. Mitchell, Anne E. Nelson, Mark J. Cowley, Warren Kaplan, Glenn Stone, Selina K. Sutton, Amie Lau, Carol M. Y. Lee, Ken K. Y. Ho   +8 more
openalex   +1 more source

Gene expression profiles complement the analysis of genomic modifiers of the clinical onset of Huntington disease [PDF]

, 2020
Galen E.B. Wright, Nicholas S. Caron, Bernard Ng, Lorenzo Casal, William Casazza, Xiaohong Xu, Jolene Ooi, Mahmoud A. Pouladi, Sara Mostafavi, Colin J.D. Ross, Michael R. Hayden   +10 more
openalex   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Native and tagged CENP-A histones are functionally inequivalent

Epigenetics & Chromatin
Background Over the past several decades, the use of biochemical and fluorescent tags has elucidated mechanistic and cytological processes that would otherwise be impossible. The challenging nature of certain nuclear proteins includes low abundancy, poor
Minh Bui, Songjoon Baek, Reda S. Bentahar, Daniël P. Melters, Yamini Dalal   +4 more
doaj   +1 more source

Associations of altered hepatic gene expression in American lifestyle-induced obesity syndrome diet-fed mice with metabolic changes during NAFLD development and progression

, 2023
Valeria Iannone, Johnson Lok, Ambrin Farizah Babu, Carlos Gómez-Gallego, Roosa-Maria Willman, Ville Koistinen, Anton Klåvus, Mikko I. Kettunen, Anna Kårlund, Ursula Schwab, Kati Hanhineva, Marjukka Kolehmainen, Hani El‐Nezami   +12 more
openalex   +1 more source

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

A scheduler for rhythmic gene expression [PDF]

Mol Syst Biol
Gaidatzis D, Graf-Landua M, Methot SP, Wölk M, Brancati G, Hauser YP, Meeuse M, Nahar S, Braun K, van der Does M, Aluri S, Kohler H, Smallwood S, Großhans H.   +13 more
europepmc   +2 more sources