Results 71 to 80 of about 13,983,545 (429)
Transcriptome-scale spatial gene expression in the human dorsolateral prefrontal cortex
Nature Neuroscience, 2020 We used the 10x Genomics Visium platform to define the spatial topography of gene expression in the six-layered human dorsolateral prefrontal cortex.
K. E. Maynard +17 more
semanticscholar +1 more source
Dendritic cells steering antigen and leukocyte traffic in lymph nodes
FEBS Letters, EarlyView.Dendritic cells are key players in the activation of T cells and their commitment to effector function. In this In a Nutshell Review, we will discuss how dendritic cells guide the trafficking of antigen and leukocytes in the lymph node, thus influencing T‐cell activation processes. Dendritic cells (DCs) play a central role in initiating and shaping the
Enrico Dotta +3 more
wiley +1 more source
Loss of TET2 and TET3 in regulatory T cells unleashes effector function
Nature Communications, 2019 Loss of TET proteins in immune cell populations is known to result in immunopathology. Here the authors show that deficiency of Tet2 and Tet3 proteins, specifically in the CD4+ FoxP3+ Treg lineage, results in a dominant pathology in which ex-Treg cells ...
Xiaojing Yue +4 more
doaj +1 more source
Unveiling interpretable development-specific gene signatures in the developing human prefrontal cortex with ICGS [PDF]
arXiv, 2022 In this paper, to unveil interpretable development-specific gene signatures in human PFC, we propose a novel gene selection method, named Interpretable Causality Gene Selection (ICGS), which adopts a Bayesian Network (BN) to represent causality between multiple gene variables and a development variable.
arxiv
Hybridization and gene expression: Beyond differentially expressed genes
Molecular EcologyAbstractGene expression has a key role in reproductive isolation, and studies of hybrid gene expression have identified mechanisms causing hybrid sterility. Here, we review the evidence for altered gene expression following hybridization and outline the mechanisms shown to contribute to altered gene expression in hybrids. Transgressive gene expression,
Runemark, Anna +2 more
openaire +3 more sources
Modeling dependent gene expression
, 2012 In this paper we propose a Bayesian approach for inference about dependence of high throughput gene expression. Our goals are to use prior knowledge about pathways to anchor inference about dependence among genes; to account for this dependence while ...
Freedman, Ralph S. +3 more
core +1 more source
Platelet gene expression and function in patients with COVID-19
Blood, 2020 There is an urgent need to understand the pathogenesis of coronavirus disease 2019 (COVID-19). In particular, thrombotic complications in patients with COVID-19 are common and contribute to organ failure and mortality.
B. Manne +13 more
semanticscholar +1 more source
The dual nature of TDC – bridging dendritic and T cells in immunity
FEBS Letters, EarlyView.TDC are hematopoietic cells combining dendritic and T cell features. They reach secondary lymphoid organs (SLOs) and peripheral organs (liver and lungs) after FLT3‐dependent development in the bone marrow and maturation in the thymus. TDC are activated and enriched in SLOs upon viral infection, suggesting that they might play unique immune roles, since
Maria Nelli, Mirela Kuka
wiley +1 more source
The Effect of Transposable Element Insertions on Gene Expression Evolution in Rodents [PDF]
, 2009 Background:Many genomes contain a substantial number of transposable elements (TEs), a few of which are known to be involved in regulating gene expression.
A Nekrutenko +36 more
core +3 more sources
FEBS Letters, EarlyView.In vivo IL‐10 produced by tissue‐resident tolDC is involved in maintaining/inducing tolerance. Depending on the agent used for ex vivo tolDC generation, cells acquire common features but prime T cells towards anergy, FOXP3+ Tregs, or Tr1 cells according to the levels of IL‐10 produced. Ex vivo‐induced tolDC were administered to patients to re‐establish/
Konstantina Morali +3 more
wiley +1 more source