Results 71 to 80 of about 5,153,058 (200)
Dualistic role of ZEB1 and ZEB2 in tumor progression
Biology DirectIt is generally accepted that ZEB1 and ZEB2 act as master regulators of the epithelial-mesenchymal transition, which arguably is the key mechanism of metastasis.
Sergey E. Parfenyev +6 more
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Nature CommunicationsDefect in the SMN1 gene causes spinal muscular atrophy (SMA), which shows loss of motor neurons, muscle weakness and atrophy. While current treatment strategies, including small molecules or viral vectors, have shown promise in improving motor function ...
Fumiyuki Hatanaka +10 more
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A role for p53 in telomere protection
Molecular & Cellular Oncology, 2017 Telomeres cap the ends of chromosomes and are crucial for genome stability. The p53 protein (TP53) is a vital tumor suppressor, activating the transcription of numerous genes in response to cell stress.
Stephen Tutton, Paul M. Lieberman
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Mathematical Models of Gene Expression
, 2019 In this paper we analyze the equilibrium properties of a large class of stochastic processes describing the fundamental biological process within bacterial cells, {\em the production process of proteins}.
Robert, Philippe
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Transient-mediated fate determination in a transcriptional circuit of HIV [PDF]
, 2007 Steady-state behavior and bistability have been proposed as mechanisms for decision-making in gene circuits. However, transient gene expression has also been proposed to control cell fate with the decision arbitrated by the lifetime of the expression ...
Leor Weinberger +2 more
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Cell Reports, 2016 Epithelial-to-mesenchymal transition (EMT) confers several traits to cancer cells that are required for malignant progression. Here, we report that miR-27b-3p-mediated silencing of the single-strand RNA binding protein KHSRP is required for transforming ...
Margherita Puppo +8 more
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, 2013 In this paper we motivate and develop a model of gene expression for the purpose of studying the interaction between synthetic gene circuits and the chassis cell within which they are in- serted.
Algar, Rhys, Ellis, Tom, Stan, Guy-Bart
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Green Fluorescent Protein (GFP) in Vector Systems Played Sense Role of Epigenetic in Plants [PDF]
, 2008 The green fluorescent protein (GFP) of jellyfish (_Aequorea victoria_) has significant advantages over other reporter genes, because expression can be detected in living cells without any substrates.
Hany A. El-Shemy +2 more
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Epigenetics and chromatin remodeling play a role in lung disease [PDF]
, 2011 Epigenetics is defined as heritable changes that affect gene expression without altering the DNA sequence. Epigenetic regulation of gene expression is facilitated through different mechanisms such as DNA methylation, histone modifications and RNA ...
Adcock, IM +3 more
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Contribution of subgenomes to the transcriptome and their intertwined regulation in the allopolyploid Coffea arabica L. grown in contrasted temperatures : W190 [PDF]
, 2013 Polyploidy occurs throughout the evolutionary history of many plants, giving rise to novel phenotypes and leading to ecological diversification and colonization of new niches.
Bertrand, Benoît +3 more
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