Results 81 to 90 of about 13,983,545 (429)
Nature Communications, 2021 Human pluripotent stem cell (hPSC) derived pancreatic beta cells are a promising and potentially limitless source for cell replacement therapy.
Haisong Liu +11 more
doaj +1 more source
Regulation-incorporated Gene Expression Network-based Heterogeneity Analysis [PDF]
arXiv, 2023 Gene expression-based heterogeneity analysis has been extensively conducted. In recent studies, it has been shown that network-based analysis, which takes a system perspective and accommodates the interconnections among genes, can be more informative than that based on simpler statistics. Gene expressions are highly regulated. Incorporating regulations
arxiv
Transcriptional coupling of neighbouring genes and gene expression noise: evidence that gene orientation and non-coding transcripts are modulators of noise [PDF]
, 2010 For some genes, notably essential genes, expression when expression is needed is vital hence low noise in expression is favourable. For others noise is necessary for coping with stochasticity or for providing dice-like mechanisms to control cell fate ...
Guang-Zhong Wang +2 more
core +2 more sources
FoxO1 signaling in B cell malignancies and its therapeutic targeting
FEBS Letters, EarlyView.FoxO1 has context‐specific tumor suppressor or oncogenic character in myeloid and B cell malignancies. This includes tumor‐promoting properties such as stemness maintenance and DNA damage tolerance in acute leukemias, or regulation of cell proliferation and survival, or migration in mature B cell malignancies.
Krystof Hlavac +3 more
wiley +1 more source
Nature Communications, 2021 Transcriptional state plays a role in genome organization, however factors that link these processes are not well known. Here, the authors show Drosophila transcription factor Motif 1-binding protein (M1BP) interacts with the insulator protein CP190 to ...
Indira Bag +6 more
doaj +1 more source
CagA and VacA Gene Expression in Helicobacter Pylori Infected Patients in Dr. Soetomo General Hospital [PDF]
, 2016 Marshall and Warren had discovered helicobacter pylori in 1982 and known as the main pathogen caused infection on human's stomach. Helicobacter pylori is a bacillus spiral and gram negative bacteria which is motile as it has almost six flagella on one ...
Alimsardjono, L. (Lindawati) +2 more
core
The impact of sex on gene expression across human tissues
Science, 2020 Sex differences in the human transcriptome are widespread and tissue specific, and they contribute to complex traits. The role of sex in the human transcriptome In humans, the inheritance of the XX or XY set of sex chromosomes is responsible for most ...
Meritxell Oliva +39 more
semanticscholar +1 more source
FEBS Letters, EarlyView.Metabolic dysfunction‐associated steatotic liver disease (MASLD) affects nearly one‐third of the global population and poses a significant risk of progression to cirrhosis or liver cancer. Here, we discuss the roles of hepatic dendritic cell subtypes in MASLD, highlighting their distinct contributions to disease initiation and progression, and their ...
Camilla Klaimi +3 more
wiley +1 more source
Zipf's Law in Gene Expression [PDF]
, 2002 Using data from gene expression databases on various organisms and tissues, including yeast, nematodes, human normal and cancer tissues, and embryonic stem cells, we found that the abundances of expressed genes exhibit a power-law distribution with an ...
G. K. Zipf +5 more
core +2 more sources
Tight control of gene expression in mammalian cells by tetracycline-responsive promoters.
Proceedings of the National Academy of Sciences of the United States of America, 1992 Control elements of the tetracycline-resistance operon encoded in Tn10 of Escherichia coli have been utilized to establish a highly efficient regulatory system in mammalian cells.
M. Gossen, H. Bujard
semanticscholar +1 more source