Results 71 to 80 of about 3,751,690 (317)

Novel biosensor for high-throughput detection of progesterone receptor-interacting endocrine disruptors

Scientific Reports
Progesterone receptor (PR)-interacting compounds in the environment are associated with serious health hazards. However, methods for their detection in environmental samples are cumbersome.
Diana A. Stavreva, Lyuba Varticovski, Razi Raziuddin, Gianluca Pegoraro, R. Louis Schiltz, Gordon L. Hager   +5 more
doaj   +1 more source

Structural basis underlying viral hijacking of a histone chaperone complex

Nature Communications, 2016
The Epstein-Barr virus tegument protein BNRF1 is required for the establishment of selective viral gene expression during latency and interacts with the histone chaperone DAXX.
Hongda Huang, Zhong Deng, Olga Vladimirova, Andreas Wiedmer, Fang Lu, Paul M. Lieberman, Dinshaw J. Patel   +6 more
doaj   +1 more source

Chemical combinations potentiate human pluripotent stem cell-derived 3D pancreatic progenitor clusters toward functional β cells

Nature Communications, 2021
Human pluripotent stem cell (hPSC) derived pancreatic beta cells are a promising and potentially limitless source for cell replacement therapy.
Haisong Liu, Ronghui Li, Hsin-Kai Liao, Zheying Min, Chao Wang, Yang Yu, Lei Shi, Jiameng Dan, Alberto Hayek, Llanos Martinez Martinez, Estrella Nuñez Delicado, Juan Carlos Izpisua Belmonte   +11 more
doaj   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Gene regulatory networks and the role of robustness and stochasticity in the control of gene expression

, 2011
In any given cell, thousands of genes are expressed and work in concert to ensure the cell's function, fitness, and survival. Each gene, in turn, must be expressed at the proper time and in the proper amounts to ensure the appropriate functional outcome.
L. T. MacNeil, A. J. M. Walhout, MacNeil, Lesley T., Albertha J.M. Walhout, Walhout, Albertha J M, Lesley T. MacNeil   +5 more
core   +1 more source

Gene expression tomography [PDF]

Physiological Genomics, 2002
Gene expression tomography, or GET, is a new method to increase the speed of three-dimensional (3-D) gene expression analysis in the brain. The name is evocative of the method’s dual foundations in high-throughput gene expression analysis and computerized tomographic image reconstruction, familiar from techniques such as positron emission tomography ...
BROWN, VANESSA M, OSSADTCHI, ALEX, KHAN, ARSHAD H, GAMBHIR, SANJIV S, CHERRY, SIMON R, LEAHY, RICHARD M, SMITH, DESMOND J   +6 more
openaire   +4 more sources

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Early gene expression divergence between allopatric populations of the house mouse (Mus musculus domesticus) [PDF]

, 2013
Divergence of gene expression is known to contribute to the differentiation and separation of populations and species, although the dynamics of this process in early stages of population divergence remains unclear. We analyzed gene expression differences
Meike Teschke, Teschke, Meike, Somel, Mehmet, Somel, M. ; https://orcid.org/, Lorenc, Anna, Bryk, Jarek, Mehmet Somel, Anna Lorenc, Bryk, Jaroslaw, Jarosław Bryk, Teschke, M., Somel, M., Bryk, J., Lorenc, A.   +13 more
core   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Fuzzy clustering of time series gene expression data with cubic-spline

, 2013
Data clustering techniques have been applied to ex- tract information from gene expression data for two decades. A large volume of novel clustering algorithms have been developed and achieved great success.
Ali, Akhtar, Wang, Yu, Angelova, Maia
core   +1 more source