Results 101 to 110 of about 3,483,446 (299)

The role and implications of mammalian cellular circadian entrainment

FEBS Letters, EarlyView.
At their most fundamental level, mammalian circadian rhythms occur inside every individual cell. To tell the correct time, cells must align (or ‘entrain’) their circadian rhythm to the external environment. In this review, we highlight how cells entrain to the major circadian cues of light, feeding and temperature, and the implications this has for our
Priya Crosby
wiley   +1 more source

Knowledge-based gene expression classification via matrix factorization [PDF]

, 2008
Motivation: Modern machine learning methods based on matrix decomposition techniques, like independent component analysis (ICA) or non-negative matrix factorization (NMF), provide new and efficient analysis tools which are currently explored to analyze ...
A. M. Tomé, Affymetrix, Allison, Baldi, Barnhill, Bolstad, Breiman, Cardoso, Cardoso, Chen, D. Lutter, Diaz-Uriarte, Diaz-Uriarte, Dougherty, Dougherty, Dudoit, E. W. Lang, F. J. Theis, G. Schmitz, Galton, Galton, Golub, Guyon, Hochreiter, Irrizarry, Lee, Li, Liebermeister, Liu, Lutter, M. Stetter, Mangasarian, P. Gómez Vilda, P. Knollmüller, Pearson, Quackenbush, R. Schachtner, Saidi, Schachtner, Schachtner, Schölkopf, Simon, Spang, Talloen, Troyanskaya, Tusher, Wu, Wu   +47 more
core   +3 more sources

Molecular bases of circadian magnesium rhythms across eukaryotes

FEBS Letters, EarlyView.
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley   +1 more source

Occupational exposure to gases/fumes and mineral dust affect DNA methylation levels of genes regulating expression [PDF]

, 2019
Many workers are daily exposed to occupational agents like gases/fumes, mineral dust or biological dust, which could induce adverse health effects. Epigenetic mechanisms, such as DNA methylation, have been suggested to play a role.
't Hoen, Peter-Bram, Amin, Najaf, Arindrarto, Wibowo, Beekman, Marian, Boezen, H Marike, Bonder, Marc Jan, Boomsma,, Dorret I, Bot, Jan, Brusselle, Guy, de Jong, Kim, de Vries, Maaike, Deelen, Joris, Deelen, Patrick, Franke, Lude, Heijmans, Bastiaan T, Hoen, Peter ACT, Hofman, Bert A, Hottenga, Jouke J, Isaacs, Aaron, Jansen, Rick, Jhamai, P Mila, Kielbasa, Szymon M, Kromhout, Hans, La Bastide-van Gemert, Sacha, Lahousse, Lies, Lakenberg, Nico, Luijk, Rene, Mei, Hailiang, Moed, Matthijs, Nedeljkovic, Ivana, Nooren, Irene, Pool, Rene, Postma, Dirkje S, Schalkwijk, Casper G, Slagboom, P Eline, Stehouwer, Coen DA, Suchiman, H Eka D, Swertz, Morris A, Terzikhan, Natalie, Tigchelaar, Ettje E, Uitterlinden, Andre G, van den Berg, Leonard H, van Der Breggen, Ruud, van Der Kallen, Carla JH, van Der Plaat, Diana, van Diemen, Cleo C, van Dijk, Freerk, van Dongen, Jenny, van Duijn, Cornelia M, van Galen, Michiel, van Greevenbroek, Marleen MJ, van Heemst, Diana, van Iterson, Maarten, van Meurs, Joyce, van Rooij, Jeroen, van Zwet, Erik W, Vant Hof, Peter, Veldink, Jan H, Verbiest, Michael, Verkerk, Marijn, Vermaat, Martijn, Vermeulen, Roel CH, Vonk, Judith M, Wijmenga, Cisca, Zhernakova, Dasha V, Zhernakova, Sasha   +65 more
core   +1 more source

Relationship between regulatory pattern of gene expression level and gene function

PLOS ONE, 2017
Regulation of gene expression levels is essential for all living systems and transcription factors (TFs) are the main regulators of gene expression through their ability to repress or induce transcription. A balance between synthesis and degradation rates controls gene expression levels.
Masayo Inoue, Katsuhisa Horimoto
openaire   +4 more sources

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Statistical calibration of qRT-PCR, microarray and RNA-Seq gene expression data with measurement error models

, 2014
The accurate quantification of gene expression levels is crucial for transcriptome study. Microarray platforms are commonly used for simultaneously interrogating thousands of genes in the past decade, and recently RNA-Seq has emerged as a promising ...
Kuczek, Thomas, Sun, Zhaonan, Zhu, Yu
core   +1 more source

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

Sparse multi-view matrix factorisation: a multivariate approach to multiple tissue comparisons

, 2015
Gene expression levels in a population vary extensively across tissues. Such heterogeneity is caused by genetic variability and environmental factors, and is expected to be linked to disease development. The abundance of experimental data now enables the
Montana, Giovanni, Wang, Zi, Yuan, Wei
core   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source