Results 291 to 300 of about 7,080,207 (344)

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Some of the next articles are maybe not open access.

Related searches:

Transient Gene Expression Levels from Multigene Expression Vectors

Biotechnology Progress, 2007
AbstractMultigene expression vectors are commonly utilized whereby the (over)expression of two or more genes is desired simultaneously and often at supposedly equivalent levels. We have characterized dual‐gene and pEE14.4 RlucMFluc expression plasmids in which the second hCMV‐MIE promoter is replaced with a c‐myc IRES to enable one‐step coordinated ...
Underhill, MF, Smales, CM, Naylor, LH, Birch, JR, James, DC   +4 more
openaire   +3 more sources

Hierarchical order of gene expression levels

2010 International Conference on Bioinformatics and Biomedical Technology, 2010
With an overwhelming amount of expression data available, many interesting problems have been studied, such as identifying cancer signatures, constructing gene regulatory networks, analyzing activity of pathways, and so on. Here we show another fascinating aspect of using expression data, constructing the hierarchical order of gene expression levels ...
Hu, Haiyan, Li, Xiaoman
openaire   +2 more sources

Base composition and expression level of human genes

Gene, 2004
It is well known that the gene distribution is non-uniform in the human genome, reaching the highest concentration in the GC-rich isochores. Also the amino acid frequencies, and the hydrophobicity, of the corresponding encoded proteins are affected by the high GC level of the genes localized in the GC-rich isochores.
Stilianos, Arhondakis, Fabio, Auletta, Giuseppe, Torelli, Giuseppe, D'Onofrio   +3 more
openaire   +2 more sources

Levels of duplicate gene expression in armoured catfishes

Journal of Heredity, 1980
Species of armoured catfishes differ significantly in their cellular DNA content and chromosome number. Starch gel electrophoresis of isozymes was used to determine whether each of 16 enzyme loci was expressed in a single or duplicate state. The percent of enzyme loci exhibiting duplicate locus expression in Corydoras aeneus, Corydoras julii, Corydoras
R A, Dunham, D P, Philipp, G S, Whitt
openaire   +2 more sources

Gene-expression analysis at the single-cell level

Trends in Pharmacological Sciences, 2000
The manner in which a cell responds to and influences its environment is ultimately determined by the genes that it expresses. To fully understand and manipulate cellular function, identification of these expressed genes is essential. Techniques such as RT-PCR enable examination of gene expression at the tissue level.
A K, Dixon, P J, Richardson, R D, Pinnock, K, Lee   +3 more
openaire   +2 more sources

Discovering High-Order Patterns of Gene Expression Levels

Journal of Computational Biology, 2008
This paper reports the discovery of statistically significant association patterns of gene expression levels from microarray data. By association patterns, we mean certain gene expression intensity intervals having statistically significant associations among themselves and with the tissue classes, such as cancerous and normal tissues.
Andrew K C, Wong, Wai-Ho, Au, Keith C C, Chan   +2 more
openaire   +2 more sources

Decreased GADD45A gene expression level in MGUS

Pamukkale Medical Journal, 2023
Purpose: Monoclonal gammopathy of undetermined significance (MGUS) is a plasma cell dyscrasia. It is known that MGUS has an increased risk of progression to multiple myeloma (MM), and also prepares the ground for diseases such as Waldenstrom macroglobulinemia (WM), non-Hodgkin lymphoma, and chronic lymphocytic leukemia (CLL).
Ilknur SUER, Aynur DAĞLAR ADAY, Gözde ÖZTAN   +2 more
openaire   +1 more source

Inferring gene expression dynamics from reporter protein levels

Biotechnology Journal, 2008
AbstractWe present a mathematical method for inferring the dynamics of gene expression from time series of reporter protein assays and cell populations. We show that estimating temporal expression dynamics from direct visual inspection of reporter protein data is unreliable when the half‐life of the protein is comparable to the time scale of the ...
David, Brown, C Phoebe, Lostroh
openaire   +2 more sources