Results 121 to 130 of about 809,277 (348)

Decoding Acute Myeloid Leukemia: A Clinician’s Guide to Functional Profiling

Diagnostics
Acute myeloid leukemia (AML) is a complex clonal disorder characterized by clinical, genetic, metabolomic, and epigenetic heterogeneity resulting in the uncontrolled proliferation of aberrant blood-forming precursor cells.
Prasad Iyer, Shaista Shabbir Jasdanwala, Yuhan Wang, Karanpreet Bhatia, Shruti Bhatt   +4 more
doaj   +1 more source

Multi-omics of 34 colorectal cancer cell lines - a resource for biomedical studies

Molecular Cancer, 2017
Background Colorectal cancer (CRC) cell lines are widely used pre-clinical model systems. Comprehensive insights into their molecular characteristics may improve model selection for biomedical studies.
Kaja C. G. Berg, Peter W. Eide, Ina A. Eilertsen, Bjarne Johannessen, Jarle Bruun, Stine A. Danielsen, Merete Bjørnslett, Leonardo A. Meza-Zepeda, Mette Eknæs, Guro E. Lind, Ola Myklebost, Rolf I. Skotheim, Anita Sveen, Ragnhild A. Lothe   +13 more
doaj   +1 more source

Expression Profiling of Tobacco Leaf Trichomes Identifies Genes for Biotic and Abiotic Stresses [PDF]

, 2010
Emiko Harada, Ji‐Ah Kim, Andreas J. Meyer, Rüdiger Hell, Stephan Clemens, Yong-Eui Choi   +5 more
openalex   +1 more source

Characterization of ovarian follicles, serum steroid hormone concentration, and steroidogenic gene expression profiles in the developing ovarian follicles in White King pigeons

, 2023
Y. Wang, Zhenyu Guo, C. Zhang, D.Z. Miao, Xueying Mao, Shengjun Lu, H.M. Yang, Zilian Wang   +7 more
openalex   +1 more source

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

Molecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath, Irene A. George, Srikanth S. Manda, Prasanth Ariyannur, Ekta R. Dhawale, Raja Sekhar Kommu, Rajan Datar, Darshana Patil, Vinita Trivedi, Manisha Singh, Kumar Prabhash, Sewanti Limaye, Richa Chauhan, Prashant Kumar   +13 more
wiley   +1 more source

The Bimodality Index: A Criterion for Discovering and Ranking Bimodal Signatures from Cancer Gene Expression Profiling Data

Cancer Informatics, 2009
Motivation: Identifying genes with bimodal expression patterns from large-scale expression profiling data is an important analytical task. Model-based clustering is popular for this purpose. That technique commonly uses the Bayesian information criterion
Jing Wang, Sijin Wen, W. Fraser Symmans, Lajos Pusztai, Kevin R. Coombes   +4 more
doaj  

YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma

Molecular Oncology, EarlyView.
The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy, Samuel Hartzler, Paula A. Vargas Carranza, Shyaman Jayasundara, Madison E. Yates, Nimod D. Janson, Bozhi Liu, Annaleigh Benton, Majid Kazemian, Jason A. Hanna   +9 more
wiley   +1 more source

Genomic identification and expression profiling of DMP genes in oat (Avena sativa) elucidate their responsiveness to seed aging

BMC Genomics
Background The Domain of unknown function 679 membrane protein (DMP) family, which is unique to plants, plays a crucial role in reproductive development, stress response and aging.
Yuan Ma, Huan Liu, Jinglong Wang, Guiqin Zhao, Kuiju Niu, Xiangrui Zhou, Ran Zhang, Ruirui Yao   +7 more
doaj   +1 more source

Detection of Growth Hormone Doping by Gene Expression Profiling of Peripheral Blood [PDF]

, 2009
Chris J. Mitchell, Anne E. Nelson, Mark J. Cowley, Warren Kaplan, Glenn Stone, Selina K. Sutton, Amie Lau, Carol M. Y. Lee, Ken K. Y. Ho   +8 more
openalex   +1 more source

Emerging role of ARHGAP29 in melanoma cell phenotype switching

Molecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster, Melanie Kappelmann‐Fenzl, Anja Katrin Bosserhoff, Nicole Rachinger   +3 more
wiley   +1 more source