Results 141 to 150 of about 479,624 (259)

Antibacterial and Antibiofilm Potential of Thymol-Benzimidazolium-Chalcone Hybrids Against Clinical MRSA Strains: Insights from Gene Expression Profiling and Molecular Docking. [PDF]

Antibiotics (Basel)
Yakut S, Ünver H, Yiğin A, Çimentepe M, Yıldız Zeyrek F, Öztürk Çimentepe Ö, Yildirim M.   +6 more
europepmc   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Comprehensive Investigation of a Novel Schiff Base: Synthesis, Anticancer Efficacy, Gene Expression Profiling, and Computational Analyses. [PDF]

Pharmaceuticals (Basel)
Agbektas T, Pazarcı Ö, Tas A, Huseynzada A, Guliyev R, Hasanova U, Buluz EC, Kaya S, Morales-Bayuelo A, Silig Y.   +9 more
europepmc   +1 more source

Interferon beta drives therapy resistance in a patient‐derived model of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant, Tise Suzuki, Kiera McGivney, V. S. S. Abhinav Ayyadevara, Sharon Asariah, Jay Deng, Ethan Nyein, Jacqueline Coats, Gary Yu, Yevgeniya J. Ioffe, Christian Hurtz, Juli J. Unternaehrer   +11 more
wiley   +1 more source

Hair follicle gene expression profiling in the SubPopulations and InteRmediate Outcome Measures in COPD Study (SPIROMICS). [PDF]

BMC Med Genomics
Buschur KL, Martorella M, Garcia-Flores R, Smith BM, Ziosi M, Barjaktarevic I, Bleecker ER, Christenson SA, Comellas AP, Criner GJ, Dransfield MT, Hansel NN, Kaner RJ, Krishnan JA, Meyers DA, Oelsner EC, Ortega VE, Paine R, Woodruff PG, Barr RG, Lappalainen T.   +20 more
europepmc   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Gene expression profiling identifies ferroptosis-related genes and pathways in human colon cancers cell lines. [PDF]

Front Mol Biosci
Balik-Meisner M, Phadke D, Mav D, Shah R, Shockley KR, Murphy C, Tokar EJ, Sinha BK.   +7 more
europepmc   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Gene Expression Profiling of Transcription Factors and Acclimation-Related Genes in <i>Ribes</i> spp. [PDF]

Int J Mol Sci
Zubauskienė AD, Misiukevičius E, Bendokas V, Njoku EG, Mažeikienė I.   +4 more
europepmc   +1 more source

Identifying key genes for European canker resistance in apple: Machine learning and gene expression profiling of quantitative disease resistance [PDF]

Sci Rep
Karlström A, Gómez-Cortecero A, Connell J, Nellist CF, Ordidge M, Dunwell JM, Harrison RJ.   +6 more
europepmc   +2 more sources