Results 181 to 190 of about 809,277 (348)

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source

Global Gene Expression Profiling in R155H Knock-In Murine Model of VCP Disease [PDF]

, 2014
Angèle Nalbandian, Svetlana Ghimbovschi, Zuyi Wang, Susan M. Knoblach, Katrina J. Llewellyn, Jouni Vesa, Eric P. Hoffman, Virginia Kimonis   +7 more
openalex   +1 more source

Supplementary Data from Gene Expression Profiling–Based Identification of Molecular Subtypes in Stage IV Melanomas with Different Clinical Outcome

, 2023
Göran Jönsson, Christian Busch, Stian Knappskog, Jürgen Geisler, Hrvoje Miletić, Markus Ringnér, Johan R. Lillehaug, Åke Borg, Per Eystein Lønning   +8 more
openalex   +1 more source

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source

[Corrigendum] Screening for implicated genes in colorectal cancer using whole‑genome gene expression profiling. [PDF]

Mol Med Rep
Sun LC, Qian HX.
europepmc   +1 more source

Intragraft gene expression profile associated with the induction of tolerance [PDF]

, 2008
Tomoko Doki, Michael J. Mello, Dennis Mock, Jacqueline M. Evans, Mary Kearns‐Jonker   +4 more
openalex   +1 more source

Supplementary Document 2 from Development and Validation of a Gene Profile Predicting Benefit of Postmastectomy Radiotherapy in Patients with High-Risk Breast Cancer: A Study of Gene Expression in the DBCG82bc Cohort

, 2023
Trine Tramm, Hayat Mohammed, Simen Myhre, Marianne Kyndi, Jan Alsner, Anne‐Lise Børresen‐Dale, Thérese Sørlie, Arnoldo Frigessi, Jens Overgaard   +8 more
openalex   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Exploratory Gene Expression Profiling of Cisplatin-Induced Neurotoxicity in Rat Brain. [PDF]

Int J Mol Sci
Torres-Pineda O, Morgado-Valle C, Chi-Castañeda D, López-Meraz ML, Rodríguez-Razón CM, Macías-Carballo M, Beltrán-Parrazal L.   +6 more
europepmc   +1 more source