Results 261 to 270 of about 809,277 (348)

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

Identifying key genes for European canker resistance in apple: Machine learning and gene expression profiling of quantitative disease resistance

Karlström A, Gómez-Cortecero A, Connell J, Nellist CF, Ordidge M, Dunwell JM, Harrison RJ.   +6 more
europepmc   +1 more source

The effect of salubrinal on the endoplasmic reticulum stress pathway in heat‐stressed spermatogonial cells in vitro

FEBS Open Bio, EarlyView.
This study investigates the protective role of salubrinal against heat‐induced endoplasmic reticulum (ER) stress in mouse spermatogenic cells (GC1 and GC2). By modulating the ER stress pathway, salubrinal alleviates cellular stress and supports spermatogenic cell survival, suggesting its potential as a therapeutic candidate for heat‐related infertility.
Suna Karadeniz Saygili, Mustafa Oztatlici, Mahmut Kemal Ozbilgin   +2 more
wiley   +1 more source

Development of Venous Thromboembolism Risk Prediction Models Based on Whole Blood Gene Expression Profiling Using 20 Machine Learning Algorithms: Comprehensive Analysis Study.

JMIR Med Inform
Huang Y, Chen X, Bai G, Zhao Y, Kuang D, Zhang L, Lu W.   +6 more
europepmc   +1 more source

Lipidome and Gene Expression Profiling in Zebrafish Liver Spheroids: A 3D Model for Environmental Toxicology Applications. [PDF]

Environ Sci Technol
Wang T, Perelló Amorós M, Porte C.
europepmc   +1 more source

Antigen-induced differential gene expression in lymphocytes and gene expression profile in synovium prior to the onset of arthritis

, 2006
Vyacheslav A. Adarichev, Csaba Vermes, Anita Hanyecz, Katalin Ludányi, Miklós Tunyogi-Csapó, Alison Finnegan, Katalin Mikecz, Tibor T. Glant   +7 more
openalex   +2 more sources

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

FEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies, Garth L. Maker, Ian F. Musgrave, Samantha Lodge   +3 more
wiley   +1 more source

Host-Virus Interface in Persistent SARS-CoV-2 Infections: Viral Characteristic Evolution and Gene Expression Profiling Analysis. [PDF]

Int J Mol Sci
Maarif AS, Nishikawa Y, Takata M, Kanai K, Riyandani E, Mukuda K, Mimura M, Yamaguchi K, Kato H, Okamoto R, Okada K, Kitaura T, Nakamoto M, Yamasaki A, Kageyama S, Chikumi H.   +15 more
europepmc   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

Spatial gene expression profiling identifies prognostic features of residual tumors after neoadjuvant chemotherapy in triple-negative breast cancer. [PDF]

Front Oncol
Won HS, Kim YS, Seo KJ, Jun SY, Sun S, Choi M, Yoon JS, Byun JH.   +7 more
europepmc   +1 more source