Results 1 to 10 of about 3,752,587 (116)

Influence of the Bioactive Diet Components on the Gene Expression Regulation [PDF]

Nutrients, 2021
Diet bioactive components, in the concept of nutrigenetics and nutrigenomics, consist of food constituents, which can transfer information from the external environment and influence gene expression in the cell and thus the function of the whole organism.
Justyna Mierziak, K. Kostyn, Aleksandra Boba, Magdalena Czemplik, A. Kulma, Wioleta Wojtasik   +5 more
semanticscholar   +2 more sources

Gene regulation by long non-coding RNAs and its biological functions

Nature Reviews Molecular Cell Biology, 2020
Evidence accumulated over the past decade shows that long non-coding RNAs (lncRNAs) are widely expressed and have key roles in gene regulation. Recent studies have begun to unravel how the biogenesis of lncRNAs is distinct from that of mRNAs and is ...
Luisa Statello, Ling-Ling Chen, Maite Huarte   +2 more
exaly   +2 more sources

The Role of lncRNAs in Gene Expression Regulation through mRNA Stabilization

Non-Coding RNA, 2021
mRNA stability influences gene expression and translation in almost all living organisms, and the levels of mRNA molecules in the cell are determined by a balance between production and decay.
M. Sebastian-delaCruz, Itziar González-Moro, A. Olazagoitia-Garmendia, A. Castellanos-Rubio, Izortze Santin   +4 more
semanticscholar   +1 more source

Large-scale cis- and trans-eQTL analyses identify thousands of genetic loci and polygenic scores that regulate blood gene expression

Nature Genetics, 2021
Trait-associated genetic variants affect complex phenotypes primarily via regulatory mechanisms on the transcriptome. To investigate the genetics of gene expression, we performed cis- and trans-expression quantitative trait locus (eQTL) analyses using ...
U. Võsa, A. Claringbould, H. Westra, M. Bonder, Patrick Deelen, B. Zeng, H. Kirsten, A. Saha, Roman Kreuzhuber, S. Yazar, H. Brugge, R. Oelen, Dylan H. de Vries, M. V. D. van der Wijst, S. Kasela, N. Pervjakova, I. Alves, M. Favé, M. Agbessi, M. Christiansen, R. Jansen, I. Seppälä, L. Tong, A. Teumer, K. Schramm, G. Hemani, J. Verlouw, H. Yaghootkar, Reyhan Sönmez Flitman, A. Brown, V. Kukushkina, A. Kalnapenkis, S. Rüeger, E. Porcu, J. Kronberg, J. Kettunen, Bernett Lee, Futao Zhang, Ting Qi, J. A. Hernandez, W. Arindrarto, F. Beutner, Julia Dmitrieva, Mahmoud Elansary, Benjamin P. Fairfax, M. Georges, B. Heijmans, A. Hewitt, M. Kähönen, Yungil Kim, J. Knight, P. Kovacs, K. Krohn, Shuang Li, M. Loeffler, U. Marigorta, Hailang Mei, Y. Momozawa, M. Müller-Nurasyid, M. Nauck, M. Nivard, B. Penninx, J. Pritchard, O. Raitakari, O. Rotzschke, E. Slagboom, C. Stehouwer, M. Stumvoll, P. Sullivan, P. ’. ’t Hoen, J. Thiery, A. Tönjes, J. van Dongen, M. van Iterson, J. Veldink, U. Völker, R. Warmerdam, C. Wijmenga, M. Swertz, A. Andiappan, G. Montgomery, S. Ripatti, M. Perola, Z. Kutalik, E. Dermitzakis, S. Bergmann, T. Frayling, J. V. van Meurs, H. Prokisch, H. Ahsan, B. Pierce, T. Lehtimäki, D. Boomsma, B. Psaty, Sina A. Gharib, P. Awadalla, L. Milani, W. Ouwehand, K. Downes, O. Stegle, A. Battle, P. Visscher, Jian Yang, M. Scholz, J. Powell, G. Gibson, T. Esko, L. Franke   +107 more
semanticscholar   +1 more source

Metabolic regulation of gene expression by histone lactylation

Nature, 2019
The Warburg effect, which originally described increased production of lactate in cancer, is associated with diverse cellular processes such as angiogenesis, hypoxia, polarization of macrophages and activation of T cells.
Di Zhang, Zhanyun Tang, He Huang, He Huang, Guolin Zhou, Chang Cui, Yejing Weng, Wenchao Liu, Sunjoo Kim, Sangkyu Lee, Mathew Perez-Neut, Jun Ding, Daniel M. Czyż, Rong Hu, Z. Ye, Maomao He, Y. G. Zheng, H. Shuman, Lunzhi Dai, Lunzhi Dai, B. Ren, R. Roeder, L. Becker, Yingming Zhao   +23 more
semanticscholar   +1 more source

RNA N6-methyladenosine methylation in post-transcriptional gene expression regulation

Genes & Development, 2015
N6-methyladenosine (m6A) is the most prevalent internal modification that occurs in the messenger RNA (mRNA) of most eukaryotes. In this review, Yue et al.
Y. Yue, Jianzhao Liu, Chuan He
semanticscholar   +1 more source

Roles of Transposable Elements in the Different Layers of Gene Expression Regulation

International Journal of Molecular Sciences, 2019
The biology of transposable elements (TEs) is a fascinating and complex field of investigation. TEs represent a substantial fraction of many eukaryotic genomes and can influence many aspects of DNA function that range from the evolution of genetic ...
Denise Drongitis, F. Aniello, L. Fucci, Aldo Donizetti   +3 more
semanticscholar   +1 more source

The Role of Long Noncoding RNAs in Gene Expression Regulation

Gene Expression Profiling in Cancer, 2019
Accumulating evidence highlights that noncoding RNAs, especially the long noncoding RNAs (lncRNAs), are critical regulators of gene expression in development, differentiation, and human diseases, such as cancers and heart diseases.
Zhijin Li, Weiling Zhao, Maode Wang, Xiaobo Zhou   +3 more
semanticscholar   +1 more source

Characterization of tissue-specific differential DNA methylation suggests distinct modes of positive and negative gene expression regulation

BMC Genomics, 2015
DNA methylation plays an important role in regulating gene expression during many biological processes. However, the mechanism of DNA-methylation-dependent gene regulation is not fully understood.
Jun Wan, V. F. Oliver, Guohua Wang, Heng Zhu, D. Zack, S. Merbs, Jiang Qian   +6 more
semanticscholar   +1 more source

Long Non-Coding RNAs in the Regulation of Gene Expression: Physiology and Disease

Non-Coding RNA, 2019
The identification of RNAs that are not translated into proteins was an important breakthrough, defining the diversity of molecules involved in eukaryotic regulation of gene expression. These non-coding RNAs can be divided into two main classes according
J. C. R. Fernandes, S. M. Acuña, J. I. Aoki, L. Floeter-Winter, S. Muxel   +4 more
semanticscholar   +1 more source