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Influence of the Bioactive Diet Components on the Gene Expression Regulation. [PDF]

open access: yesNutrients, 2021
Diet bioactive components, in the concept of nutrigenetics and nutrigenomics, consist of food constituents, which can transfer information from the external environment and influence gene expression in the cell and thus the function of the whole organism.
Mierziak J   +5 more
europepmc   +2 more sources

The Role of lncRNAs in Gene Expression Regulation through mRNA Stabilization. [PDF]

open access: yesNoncoding RNA, 2021
mRNA stability influences gene expression and translation in almost all living organisms, and the levels of mRNA molecules in the cell are determined by a balance between production and decay.
Sebastian-delaCruz M   +4 more
europepmc   +2 more sources

Gene regulation by long non-coding RNAs and its biological functions

open access: yesNature Reviews Molecular Cell Biology, 2020
Evidence accumulated over the past decade shows that long non-coding RNAs (lncRNAs) are widely expressed and have key roles in gene regulation. Recent studies have begun to unravel how the biogenesis of lncRNAs is distinct from that of mRNAs and is ...
Luisa Statello   +2 more
exaly   +2 more sources

Regulation of S100A10 Gene Expression [PDF]

open access: yesBiomolecules, 2021
S100A10, a member of the S100 family of Ca2+-binding proteins, is a widely distributed protein involved in many cellular and extracellular processes. The best recognized role of S100A10 is the regulation, via interaction with annexin A2, of plasminogen conversion to plasmin.
Aleksandra Głowacka   +5 more
openaire   +3 more sources

A minimal bile salt excretory pump promoter allows bile acid-driven physiological regulation of transgene expression from a gene therapy vector

open access: yesCell & Bioscience, 2022
Background Bile acid (BA) homeostasis is mainly regulated by bile salt excretory pump (BSEP), a hepatocyte transporter that transfers BAs to the bile.
Javier Martínez-García   +6 more
doaj   +1 more source

The role of CPEB family proteins in the nervous system function in the norm and pathology

open access: yesCell & Bioscience, 2021
Posttranscriptional gene regulation includes mRNA transport, localization, translation, and regulation of mRNA stability. CPEB (cytoplasmic polyadenylation element binding) family proteins bind to specific sites within the 3′-untranslated region and ...
Eugene Kozlov   +4 more
doaj   +1 more source

Regulation of Involucrin Gene Expression [PDF]

open access: yesJournal of Investigative Dermatology, 2004
The epidermis is a dynamic renewing structure that provides life-sustaining protection from the environment. The major cell type of the epidermis, the epidermal keratinocyte, undergoes a carefully choreographed program of differentiation. Alteration of these events results in a variety of debilitating and life-threatening diseases.
Gautam Adhikary   +9 more
openaire   +3 more sources

Idiotype vaccines produced with a non-cytopathic alphavirus self-amplifying RNA vector induce antitumor responses in a murine model of B-cell lymphoma

open access: yesScientific Reports, 2021
A promising therapy for patients with B-cell lymphoma is based on vaccination with idiotype monoclonal antibodies (mAbs). Since idiotypes are different in each tumor, a personalized vaccine has to be produced for each patient.
Erkuden Casales   +11 more
doaj   +1 more source

Topoisomerase 1 cleavage complex enables pattern recognition and inflammation during senescence

open access: yesNature Communications, 2020
Here, the authors show that the topoisomerase 1-DNA covalent cleavage complex plays a critical role in mediating cytoplasmic chromatin fragments recognition by cyclic GMP-AMP synthase during senescence.
Bo Zhao   +11 more
doaj   +1 more source

Localization and Functional Roles of Components of the Translation Apparatus in the Eukaryotic Cell Nucleus

open access: yesCells, 2021
Components of the translation apparatus, including ribosomal proteins, have been found in cell nuclei in various organisms. Components of the translation apparatus are involved in various nuclear processes, particularly those associated with genome ...
Zaur M. Kachaev   +4 more
doaj   +1 more source

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