Results 181 to 190 of about 437,526 (312)

Research Advances in MicroRNA-Mediated Regulation of Bamboo Organ Development. [PDF]

Plants (Basel)
Yao W, Tan Q, Gu H, Zhou R, Ding Y, Lin S.   +5 more
europepmc   +1 more source

A gene regulatory network for cell differentiation in Caenorhabditis elegans

, 2003
Biological development is a remarkably complex process. A single cell, in an appropriate environment, contains enough information to produce a wide variety of specialised cell types, whose spatial and temporal dynamics interact to form intricately ...
Geard, N L, Wiles, J
core  

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

<i>T</i> Gene Mutation Leads to Short Tail in Sheep via Premature AER Degeneration: Single-Cell Evidence from Embryos. [PDF]

Animals (Basel)
Su H, Yang Y, Zuo Y, Song Y, Wang D, Zhang M, Cao G.   +6 more
europepmc   +1 more source

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source

RNA-protein complexes as key regulators of plant secondary metabolism: Biophysical interactions and functional significance. [PDF]

Biochem Biophys Rep
Ugwu OP, Ugwu MN, Onohuean H, Rather HA, Usman IM.   +4 more
europepmc   +1 more source

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source

Genome-Wide Characterization of the WOX Gene Family in <i>Polygonatum cyrtonema</i> and Its Applications for Regeneration. [PDF]

Plants (Basel)
Shi Y, Huang B, Li C, Si J, Chen D.
europepmc   +1 more source

Exon 7 splicing of ERα predicts poor prognosis and increases phenotypic heterogeneity in luminal a subtype breast cancer

FEBS Open Bio, EarlyView.
ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui, Taobo Hu, Thomson Christian Husein, Wai Hei Shek, Bingrong Chen, Depeng Wang, Shu Wang, Weichuan Yu, Xiaodan Fan, Mengping Long, Toyotaka Ishibashi   +10 more
wiley   +1 more source

A Conserved miR172-<i>TOE1</i> Module Coordinates Immunity and Flowering to Confer Verticillium Wilt Resistance in <i>Arabidopsis thaliana</i> and Cotton. [PDF]

Plants (Basel)
Yu Z, Xu L, Njoki WD, Hu X, Wei R, Du R, Sheng C, Bilal MS, Umida I, Zhao H.   +9 more
europepmc   +1 more source