Results 111 to 120 of about 544,702 (294)

Candida albicans induces Metabolic Reprogramming in human NK cells and responds to Perforin with a Zinc Depletion Response

Frontiers in Microbiology, 2016
As part of the innate immune system, natural killer (NK) cells are directly involved in the response to fungal infections. Perforin has been identified as the major effector molecule acting against many fungal pathogens.
Daniela eHellwig, Jessica eVoigt, Maria eBouzani, Jürgen eLöffler, Daniela eAlbrecht-Eckardt, Michael eWeber, Sascha eBrunke, Ronny eMartin, Oliver eKurzai, Oliver eKurzai, Kerstin eHünniger   +10 more
doaj   +1 more source

Leptin May Promote Eosinophilic CRSwNP Progression by Enhancing Eosinophil Chemotaxis and Angiogenesis Under a Type 2 Inflammatory Milieu

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Chronic rhinosinusitis with nasal polyp (CRSwNP) is a heterogeneous Type 2 inflammatory disease characterized by enhanced eosinophilic infiltration. Both innate and adaptive immunity are involved in the onset and progression of CRSwNP.
Yuki Sonoda, Yohei Sato, Yoshimasa Imoto, Mayumi Tamari, Shigeharu Fujieda   +4 more
wiley   +1 more source

Chronic alcohol consumption compromises gut barrier integrity and promotes endotoxemia: Implications for sepsis susceptibility in immunocompromised hosts

Animal Models and Experimental Medicine, EarlyView.
Chronic alcohol exposure disrupts intestinal barrier integrity, resulting in a leaky gut and enhanced translocation of lipopolysaccharide (LPS) and microbial products into the systemic circulation. Alcohol‐induced endotoxemia drives exaggerated pro‐inflammatory responses, mitochondrial damage, and activation of the cGAS–STING pathway, particularly in ...
Thansita Bhunyakarnjanarat, Chatsuree Suksamai, Dhammika Leshan Wannigama, Kent Doi, Wiwat Chancharoenthana, Asada Leelahavanichkul   +5 more
wiley   +1 more source

Single-Cell Transcript Profiling of Barley Attacked by the Powdery Mildew Fungus

Molecular Plant-Microbe Interactions, 2007
In many plant-pathogen interactions, there are several possible outcomes for simultaneous attacks on the same leaf. For instance, an attack by the powdery mildew fungus on one barley leaf epidermal cell may succeed in infection and formation of a ...
Torben Gjetting, Peter H. Hagedorn, Patrick Schweizer, Hans Thordal-Christensen, Timothy L. W. Carver, Michael F. Lyngkjær   +5 more
doaj   +1 more source

Regulation of gene expression by acidic pH in an opportunistic human fungal pathogen Cryptococcus neoformans: modulating antifungal susceptibility and iron Uptake

, 2020
Cryptococcus neoformans is an opportunistic human fungal pathogen, but its infection is militated by phagocytosis and phagolysosomes in the host immune system. It has been reported that the pH of phagolysosomes containing C. neoformans is approximately 5.3.
Kim, Donghyeun, Jung, Won Hee
openaire   +1 more source

Host's innate immune response to fungal and bacterial agents in vitro: up‐regulation of interleukin‐15 gene expression resulting in enhanced natural killer cell activity

Immunology, 2003
SummaryNatural killer (NK) cells play an important role in the first line of defence against viral infections. We have shown earlier that exposure of human peripheral blood mononuclear cells (PBMC) to viruses results in rapid up‐regulation of NK cell activity via interleukin‐15 (IL‐15) induction, and that this mechanism curtails viral infection in ...
Phay, Tran, Rasheed, Ahmad, Jingwu, Xu, Ali, Ahmad, José, Menezes   +4 more
openaire   +3 more sources

Selenium Nanomaterials for Wound Healing: Synergistic Strategies from Anti‐Infection to Tissue Regeneration

Advanced NanoBiomed Research, EarlyView.
Selenium nanoparticles (SeNPs) are emerging as multifunctional platforms for wound healing, integrating antimicrobial, anti‐inflammatory, and proregenerative activities. This review summarises key mechanisms and recent advances in SeNP‐enabled composite dressings, immunomodulatory nanocomposites, microenvironment‐responsive hydrogels, photothermal and ...
Yangxia Chen, Xiaoshuang Liang, Sirui Li, Shuoshan Li, Wei Liu, Yingping Lin, Siqi Li, Zehang Zhang, Judun Zheng, Tianfeng Chen, Rongyi Chen   +10 more
wiley   +1 more source

Role and molecular mechanism of epigenetic regulation during the development and pathogenesis of plant pathogenic fungi

浙江大学学报. 农业与生命科学版
Over a long period of evolution, plant pathogenic fungi have developed a wide range of intricate and sophisticated strategies to invade their host plants, and the precise regulation of gene expression is necessary for interactions between plants and ...
SUN Ziyue, TAO Zeng
doaj   +1 more source

Chitosan/Gelatin Hydrogels With Hydroxyapatite/Silver Nanoparticles: A Dual Antimicrobial and Biocompatible Platform for Bone Regeneration

Journal of Applied Polymer Science, EarlyView.
Chitosan/gelatin hydrogels containing hydroxyapatite or hydroxyapatite/silver nanoparticles were developed and evaluated for bone tissue engineering applications, demonstrating biocompatibility and antimicrobial activity. ABSTRACT Bone tissue engineering demands multifunctional biomaterials capable of promoting regeneration while preventing local ...
Elisabeth Assis Martins Machado, Anne Caroline da Silva Rocha, Lívia Rodrigues de Menezes   +2 more
wiley   +1 more source

Heat Stress and Gut Microbiome Dynamics in Poultry: Interplay, Consequences, and Mitigation Strategies

Animal Research and One Health, EarlyView.
Heat stress disrupts gut microbial balance in poultry, impairing nutrient absorption and immunity. This review outlines the interplay between thermal stress and microbiome dynamics and discusses integrative mitigation strategies, probiotics, phytogenics, cooling systems, and genetic adaptation to enhance poultry resilience.
O. E. Oke, A. I. Oni, O. A. Akosile, K. M. Oliyide, C. A. Ishola, M. O. Logunleko, O. A. Jimoh, C. P. Njoku, L. O. Fasasi, V. A. Uyanga   +9 more
wiley   +1 more source