Results 111 to 120 of about 7,107,261 (334)

The Ustilago maydis Cys₂His₂‐type zinc finger transcription factor Mzr1 regulates fungal gene expression during the biotrophic growth stage [PDF]

Molecular Microbiology, 2008
SummaryThe smut fungus Ustilago maydis establishes a biotrophic relationship with its host plant maize to progress through sexual development. Here, we report the identification and characterization of the Cys2His2‐type zinc finger protein Mzr1 that functions as a transcriptional activator during host colonization. Expression of the U.
Zheng, Y., Kief, J., Auffarth, K., Farfsing, J., Mahlert, M., Nieto, F., Basse, C.   +6 more
openaire   +3 more sources

Effect of introns and AT-rich sequences on expression of the bacterial hygromycin B resistance gene in the basidiomycete Schizophyllum commune [PDF]

, 2001
Previously, it was shown that introns are required for efficient mRNA accumulation in Schizophyllum commune and that the presence of AT-rich sequences in the coding region of genes can result in truncation of transcripts in this homobasidiomycete.
Scholtmeijer, K., Springer, J., Wosten, H.A.B., Scholtmeijer, K, Wessels, J.G.H., Springer, J, Wosten, HAB, Wessels, JGH   +7 more
core   +1 more source

Lipidomic Profile Reconstruction of Therapeutic Membrane Targets Using Physics‐Based Optimization with Limited Activity Data

Advanced Science, EarlyView.
Using a minimal set of experimentally labeled antimicrobial and non‐antimicrobial peptides, we reconstruct the effective lipid composition of a pathogenic membrane ‐demonstrated at the example of bacterial membranes‐ through a physics‐based evolutionary molecular dynamics (Evo‐MD) approach. Optimization based on peptide insertion reveals broad‐spectrum
Maximilian Krebs, Herre Jelger Risselada
wiley   +1 more source

The MoSR-MoDde1 Regulatory Axis: A Novel Determinant of DMI Sensitivity and a Target for Sustainable Rice Blast Control. [PDF]

Adv Sci (Weinh)
The transcription factor MoSR governs DMI fungicide sensitivity in Magnaporthe oryzae through dual regulation of ergosterol biosynthesis and the detoxification enzyme MoDde1. Targeting MoDde1 via a small‐molecule inhibitor or host‐induced gene silencing enhances DMI efficacy against rice blast, offering a sustainable disease management strategy ...
Meng FZ, Wei WK, Wu MY, Cai MZ, Wang YF, Zhao L, Meng S, Yin LF, Schnabel G, Yin WX, Luo CX.   +10 more
europepmc   +2 more sources

The transcriptional repressor Ssn6 modulates phase separation to regulate fungal gene expression

mBio
ABSTRACT The transcriptional regulation of cell fate plays a central role in eukaryotic cell differentiation. In the human fungal pathogen Candida albicans , the white-to-opaque cell fate switch is controlled by an ...
Maureen A. Dowell, Mae I. Staples, Corey Frazer, Richard J. Bennett   +3 more
openaire   +1 more source

Regulation of gene expression in developing pea seeds [PDF]

, 1989
Three classes of legumin, encoded by the gene sub-families legA, legJ and legS, and a lectin encoded by a single gene, lecA, accumulate in the developing cotyledons of Pisum sativum L.
Thompson, Andrew John
core  

A C‐Nucleoside Analogue of Cordycepin With High Metabolic Stability and Potent Anti‐Psoriatic Activity via Microneedle Delivery

Advanced Science, EarlyView.
This work identified CPD3a as a potent, stable C‐nucleoside cordycepin derivative. When formulated into microneedle array for topical treatment, it ameliorated psoriasis by rebalancing immunity and enhancing antioxidant defenses. ABSTRACT Psoriasis is a chronic inflammatory disorder characterized by immune dysregulation and epidermal hyperplasia ...
Wenfang Pan, Xinyue Shao, Yuanchen Zhong, Xujie Sun, Lixuan Yin, Zongyan He, Tianqun Lang, Yuanchao Xie   +7 more
wiley   +1 more source

Human aldolase C: gene transcriptional regulation and protein functional role [PDF]

, 2011
Aldolase C is the brain-specific aldolase isoenzyme. In the human brain, aldolase C messenger and protein are expressed in a stripe-like pattern in the Purkinje cells of the cerebellum, in the inferior olives and in the Goll and Burdach nuclei of the ...
Serio, Laura
core   +1 more source

The Transcription Factor PoCon7 Is Essential for Fungal Viability and Regulates Chitinase Gene Expression in Penicillium oxalicum

International Journal of Molecular Sciences
The dynamic remodeling of the fungal cell wall depends on a balance between chitin synthesis and degradation. Chitinases are critical for nutrient acquisition, cell wall remodeling, and defense; yet, the upstream regulatory mechanisms controlling chitinase gene expression remain poorly understood.
Kexuan Ma, Haiyi Yuan, Jian Zhao, Yuqi Qin   +3 more
openaire   +2 more sources

Chimeric IL‐6/4R‐LL37 Engineered Macrophages Achieve Synchronized Inflammation Control and Antimicrobial Defence in Sepsis

Advanced Science, EarlyView.
Engineered macrophages programmed in situ by LNP‐delivered IL‐6/4 fusion and LL37 mRNAs simultaneously dampen cytokine storm, promote M2‐like repair, and enhance direct bacterial killing in sepsis. This combinatorial strategy restores T cell and macrophage function, lowers organ bacterial burden, and improves survival, highlighting a precision, host ...
Tianyang Jie, Zheyu Zhang, Hao Zhang, Linke Bian, Penglong Zheng, Sijia Zhou, Minqi Wang, Mingyu Qu, Yufei Wang, Xinhua Qu, Bing Yue   +10 more
wiley   +1 more source