Results 141 to 150 of about 664,017 (364)
Unsupervised learning of transcriptional regulatory networks via latent tree graphical models [PDF]
arXiv, 2016 Gene expression is a readily-observed quantification of transcriptional activity and cellular state that enables the recovery of the relationships between regulators and their target genes. Reconstructing transcriptional regulatory networks from gene expression data is a problem that has attracted much attention, but previous work often makes the ...
arxiv
Geometric Characteristics of Dynamic Correlations for Combinatorial Regulation in Gene Expression Noise [PDF]
, 2009 Knowing which mode of combinatorial regulation (typically, AND or OR logic operation) that a gene employs is important for determining its function in regulatory networks. Here, we introduce a dynamic cross-correlation function between the output of a gene and its upstream regulator concentrations for signatures of combinatorial regulation in gene ...
arxiv +1 more source
Gene expression in growing cells: A biophysical primer [PDF]
arXiv, 2023 Cell growth and gene expression, essential elements of all living systems, have long been the focus of biophysical interrogation. Advances in single-cell methods have invigorated theoretical studies into these processes. However, until recently, there was little dialog between the two areas of study.
arxiv
Functional exploration of co-expression networks identifies a nexus for modulating protein and citric acid titres in Aspergillus niger submerged culture [PDF]
, 2019 Background: Filamentous fungal cell factories are used to produce numerous proteins, enzymes, and organic acids. Protein secretion and filamentous growth are tightly coupled at the hyphal tip. Additionally, both these processes require ATP and amino acid
Cairns, Timothy C. +6 more
core +1 more source
Advanced Science, EarlyView.This study uncovers that CD38high monocytes discriminate sepsis and sterile inflammation and are associated with 28‐day mortality in bacterial sepsis. Targeting CD38 therapy reduces inflammatory response in monocytes and in sepsis mice model. Mechanistically, CD38‐HIF‐1α/glycolysis/MGO loop exacerbates sepsis‐induced immune dysregulation.
Ning Hua +19 more
wiley +1 more source
Frontiers in Microbiology, 2016 As part of the innate immune system, natural killer (NK) cells are directly involved in the response to fungal infections. Perforin has been identified as the major effector molecule acting against many fungal pathogens.
Daniela eHellwig +10 more
doaj +1 more source
A dynamical system model for predicting gene expression from the epigenome [PDF]
arXiv, 2020 Gene regulation is an important fundamental biological process. The regulation of gene expression is managed through a variety of methods including epigenetic processes (e.g., DNA methylation). Understanding the role of epigenetic changes in gene expression is a fundamental question of molecular biology.
arxiv
A multifunctional, synthetic Gaussia princeps luciferase reporter for live imaging of Candida albicans infections [PDF]
, 2009 Peer reviewedPublisher ...
Brown, Alistair J P +7 more
core +3 more sources
PLoS ONE, 2011 While Caenorhabditis elegans specifically responds to infection by the up-regulation of certain genes, distinct pathogens trigger the expression of a common set of genes.
I. Engelmann +8 more
semanticscholar +1 more source
Advanced Science, EarlyView.Ultrasound (US)‐treated nanocomposite ‘lever’ hydrogels reprogrammed wound reactive oxygen species (ROS) levels and promoted wound healing in infected diabetic foot ulcers. Abstract Diabetic foot ulcers (DFUs) are a complex mixture of neuropathy, peripheral arterial disease, and infection, where excessive reactive oxygen species (ROS) exacerbates ...
Yuting Shen +16 more
wiley +1 more source