Results 141 to 150 of about 562,158 (338)

Regulation of gene expression by acidic pH in an opportunistic human fungal pathogen Cryptococcus neoformans: modulating antifungal susceptibility and iron Uptake

, 2020
Cryptococcus neoformans is an opportunistic human fungal pathogen, but its infection is militated by phagocytosis and phagolysosomes in the host immune system. It has been reported that the pH of phagolysosomes containing C. neoformans is approximately 5.3.
Donghyeun Kim, Jung, Won Hee
openaire   +1 more source

Precision Editing of NLRS Improves Effector Recognition for Enhanced Disease Resistance

Advanced Science, EarlyView.
Precision engineering of plant NLR immune receptors enables rational design of enhanced pathogen resistance through mismatched pairing, domain swapping, and targeted mutagenesis. These approaches achieve multi‐fold expansion in recognition breadth while minimizing autoimmunity risks and fitness penalties.
Vinit Kumar, Vishwa I. P. W. A. Kumara, Pradeepa C. G. Bandaranayake, Dong Yawen, Yang‐Yang Gao, Junfeng Liu, Ge‐Fei Hao, Xiu‐Fang Xin   +7 more
wiley   +1 more source

Phosphomannosylation and the functional analysis of the extended Candida albicans MNN4-like gene family [PDF]

, 2017
We thank Luz A. López-Ramírez (Universidad de Guanajuato) for technical assistance. This work was supported by Consejo Nacional de Ciencia y Tecnología (ref. CB2011/166860; PDCPN2014-247109, and FC 2015-02-834), Universidad de Guanajuato (ref. 000025/11;
Alma K. Tamez-Castrellón, Bernardo Franco, Diana F. Díaz-Jiménez, Diana M. Clavijo-Giraldo, Elías Trujillo-Esquivel, Héctor M. Mora-Montes, Kai Jin, Kai Jin, Marco J. Hernández-Chávez, Neil A. R. Gow, Roberto J. González-Hernández   +10 more
core   +2 more sources

MDP25‐VDAC3 Complex Orchestrates Actin Remodeling and Mitochondrial Dynamics to Modulate Innate Immunity in Arabidopsis

Advanced Science, EarlyView.
This study reveals that actin remodeling regulates mitochondrial elongation as a defense strategy in plants. Flagellin perception induces fusion‐dependent elongation, supported by cortical actin bundles, to repair damage and boost ATP and ROS production.
Junxiu Hou, Pengfei Lu, Xuan Cui, Liangfeng Luo, Qing Pan, Jiejie Li   +5 more
wiley   +1 more source

RNA interference screening reveals host CaMK4 as a regulator of cryptococcal uptake and pathogenesis [PDF]

, 2017
Cryptococcus neoformans , the causative agent of cryptococcosis, is an opportunistic fungal pathogen that kills over 200,000 individuals annually. This yeast may grow freely in body fluids, but it also flourishes within host cells.
Doering, Tamara L, Hole, Camaron R, Khader, Shabaana A, Srikanta, Deepa, Williams, Matthew   +4 more
core   +2 more sources

Differential regulation of gene expression in the obligate biotrophic interaction of Uromyces fabae with its host Vicia faba.

Molecular Plant-Microbe Interactions, 2001
Classical analysis of obligate biotrophic fungi revealed changes of enzyme activities or the concentration of metabolites in infected areas. However, due to the intricate integration of host and parasite metabolism, it was not possible to delineate the ...
S. Wirsel, R. Voegele, K. Mendgen
semanticscholar   +1 more source

Principles for Rigorous Design and Application of Synthetic Microbial Communities

Advanced Science, EarlyView.
SynComs are artificially designed to enable inter‐species metabolic interactions, metabolic division of labor, and ecological interactions that can elicit phenotypes like colonization stability and environmental adaptation. This systematic review explores the processes used to construct SynComs, the assessment of the mechanisms of metabolic interaction
Yuxiao Zhang, Minyu Jing, Lihui Lyu, Li Nie, Xihui Xu, Ru Sun, Xiyuan Xu, Siyu Chen, Shuobing He, Yumeng Zhang, Ping Huang, Weijie Luo, Jiaojiao Liang, Guifeng Gao, Kunkun Fan, Teng Yang, Liyan Zhang, Xiao Fu, Sarah M. Allard, Jack A. Gilbert, Jiabao Zhang, Haiyan Chu   +21 more
wiley   +1 more source

Single-Cell Transcript Profiling of Barley Attacked by the Powdery Mildew Fungus

Molecular Plant-Microbe Interactions, 2007
In many plant-pathogen interactions, there are several possible outcomes for simultaneous attacks on the same leaf. For instance, an attack by the powdery mildew fungus on one barley leaf epidermal cell may succeed in infection and formation of a ...
Torben Gjetting, Peter H. Hagedorn, Patrick Schweizer, Hans Thordal-Christensen, Timothy L. W. Carver, Michael F. Lyngkjær   +5 more
doaj   +1 more source

Amodiaquine Enhances Anti‐Melanoma Efficacy of Attenuated Salmonella via Targeting Glutathione Reductase in Neutrophils

Advanced Science, EarlyView.
This study shows that Salmonella VNP20009 recruits pro‐tumor neutrophils that reduce its anticancer efficacy. Combining VNP with amodiaquine selectively eliminates these neutrophils by targeting glutathione reductase. A GR‐shRNA‐loaded VNP strain was further developed, demonstrating an innovative strategy integrating drug repurposing with synthetic ...
Wanfa Dong, Chunyuan Zhao, Chengxi Li, Lin Weng, Zehan Ji, Peiqi Li, Jiqiang Lu, Danni Liu, Anni Yu, Tianyi Jiang, Shaokai Huang, Heng Liu, Xiao Chen, Zichun Hua   +13 more
wiley   +1 more source

Role and molecular mechanism of epigenetic regulation during the development and pathogenesis of plant pathogenic fungi

浙江大学学报. 农业与生命科学版
Over a long period of evolution, plant pathogenic fungi have developed a wide range of intricate and sophisticated strategies to invade their host plants, and the precise regulation of gene expression is necessary for interactions between plants and ...
SUN Ziyue, TAO Zeng
doaj   +1 more source