Results 111 to 120 of about 282,173 (256)

Molecular testing of soft tissue tumors

Diagnostic Cytopathology, Volume 51, Issue 1, Page 12-25, January 2023., 2023
Abstract Background The diagnosis of soft tissue tumors is challenging, especially when the evaluable material procured is limited. As a result, diagnostic ancillary testing is frequently needed. Moreover, there is a trend in soft tissue pathology toward increasing use of molecular results for tumor classification and prognostication. Hence, diagnosing
Douglas Rottmann, Eman Abdulfatah, Liron Pantanowitz   +2 more
wiley   +1 more source

Identification of genes differentially expressed as result of adenovirus type 5- and adenovirus type 12-transformation

BMC Genomics, 2009
Background Cells transformed by human adenoviruses (Ad) exhibit differential capacities to induce tumours in immunocompetent rodents; for example, Ad12-transformed rodent cells are oncogenic whereas Ad5-transformed cells are not.
Kellam Paul, Georgopoulos Lindsay J, Strath Janet, Blair G Eric   +3 more
doaj   +1 more source

Enhancer Extrachromosomal Circular DNA ANKRD28 Elicits Drug Resistance via POU2F2‐Mediated Transcriptional Network in Multiple Myeloma

Advanced Science, EarlyView.
Enhancer eccANKRD28‐manipulated MM cells have been demonstrated to facilitate drug resistance and promote MM progression by activating the key transcription factor, POU2F2. POU2F2 interacts with sequence‐specific eccANKRD28 as well as RUNX1 and RUNX2 motifs to form the protein complex, which activates the promoter of oncogenes (IRF4, JUNB, IKZF3, et al.
Binzhen Chen, Jia Liu, Yaoxin Zhang, Changming Shi, Di Zhu, Guoqiang Zhang, Fei Xiao, Lu Zhong, Minyue Zhang, Lai Guan Ng, Honghui Huang, Tingting Lu, Jian Hou   +12 more
wiley   +1 more source

The basics of commonly used molecular techniques for diagnosis, and application of molecular testing in cytology

Diagnostic Cytopathology, Volume 51, Issue 1, Page 83-94, January 2023., 2023
Abstract Molecular diagnostics has expanded to become the standard of care for a variety of solid tumor types. With limited diagnostic material, it is often desirable to use cytological preparations to provide rapid and accurate molecular results. This review covers important pre‐analytic considerations and limitations, and a description of common ...
Scott A. Turner, Rand Abou Shaar, Zhongbo Yang   +2 more
wiley   +1 more source

Single nucleotide polymorphisms that modulate microRNA regulation of gene expression in tumors [PDF]

arXiv, 2018
Genome-wide association studies (GWAS) have identified single nucleotide polymorphisms (SNPs) associated with trait diversity and disease susceptibility, yet the functional properties of many genetic variants and their molecular interactions remains unclear.
arxiv  

MISP Suppresses Ferroptosis via MST1/2 Kinases to Facilitate YAP Activation in Non‐Small Cell Lung Cancer

Advanced Science, EarlyView.
This study explores the role of Mitotic Spindle Positioning (MISP) as a key inhibitor of ferroptosis in non‐small cell lung cancer (NSCLC). MISP upregulation in NSCLC tissues leads to ferroptosis resistance, promoting cell proliferation. Mechanistically, MISP suppresses Hippo signaling via MST1/2 kinases, activating YAP and enhancing SLC7A11 expression,
Fuquan Zhang, Bingtao Huang, Yiming Xu, Guohong Cao, Mingjing Shen, Changmin Liu, Judong Luo   +6 more
wiley   +1 more source

Tissue‐resident CD69+CXCR6+ Natural Killer cells with exhausted phenotype accumulate in human non‐small cell lung cancer

European Journal of Immunology, Volume 52, Issue 12, Page 1993-2005, December 2022., 2022
This study identified a CD69+CXCR6+ tissue‐resident NK (trNK) subset specifically accumulated in the tumor microenvironment of human non‐small cell lung cancer patients. CD69+CXCR6+ trNK cells showed an immunomodulatory‐like and exhaustion phenotype, and secreted IFN‐γ and TNF‐α rapidly. Abstract Natural killer (NK) cells with tissue‐residency features
Xiaoke Chen, Yongyuan Chen, Zhongwei Xin, Mingjie Lin, Zhixing Hao, Di Chen, Teng He, Lufeng Zhao, Dang Wu, Pin Wu, Ying Chai   +10 more
wiley   +1 more source

A critical evaluation of microRNA biomarkers in non-neoplastic disease.

PLoS ONE, 2014
BackgroundMicroRNAs (miRNAs) are small (∼22-nt), stable RNAs that critically modulate post-transcriptional gene regulation. MicroRNAs can be found in the blood as components of serum, plasma and peripheral blood mononuclear cells (PBMCs).
Baqer A Haider, Alexander S Baras, Matthew N McCall, Joshua A Hertel, Toby C Cornish, Marc K Halushka   +5 more
doaj   +1 more source

Single‐Cell Analysis Clarifies Pathological Heterogeneity in Tenosynovial Giant Cell Tumor and Identifies Biomarkers for Predicting Disease Recurrence

Advanced Science, EarlyView.
MP3 tumor cells, a specific subpopulation of tumor cells in D‐TGCT, regulated the differentiation of CD34+ Fbs into MMP3+ Fbs and APOE+ Fbs through COL6A3 − (ITGAV + ITGB8) interaction. APOE+ Fbs activated IL‐1B+CCL20+ Mφs through the CXCL12/CXCR4 axis. IL‐1B+CCL20+ Mφs and MMP3+ Fbs participated in the local invasion of D‐TGCT.
Yubin Xie, Chen Chen, Fei Wu, Yiman Peng, Jing Su, Yang Zhao, Hongjie Huang, Zhong Alan Li, Yin Pei, Wencui Li, Yi He, Tianchen Xue, Chenxi Cao, Sui Peng, Xin Zhang, Weidong Song   +15 more
wiley   +1 more source

miR-126 and miR-126*: New Players in Cancer

The Scientific World Journal, 2010
Cancer progression is characterized by autarky in growth signals, insensitivity to growth-restrictive signals, evasion of apoptosis, a limitless potential to replicate, sustained angiogenesis, and tissue invasion, including metastasis.
Jeannette Meister, Mirko H. H. Schmidt
doaj   +1 more source