Results 91 to 100 of about 1,893,780 (318)

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

A mouse model for functional dissection of TAB1 O-GlcNAcylation [version 2; peer review: 2 approved]

Wellcome Open Research, 2020
Background: O-GlcNAcylation is a posttranslational modification associated with various physiological and pathophysiological processes including diabetes, cancer, neurodegeneration and inflammation.
Florence Authier, Villő Muha, Daan M.F. van Aalten   +2 more
doaj   +1 more source

Identification of hepatocyte nuclear proteins wich interact with the human C-reactive promoter

, 1989
Regulation of Human C-reactive protein gene ...
Ciliberto G, Ganter U, Majello B, Arpaia G, Toniatti C., ARCONE, Rosaria   +5 more
core  

Insights into the regulation of intrinsically disordered proteins in the human proteome by analyzing sequence and gene expression data [PDF]

, 2009
Background: Disordered proteins need to be expressed to carry out specified functions; however, their accumulation in the cell can potentially cause major problems through protein misfolding and aggregation.
Edwards, Y.J.K., Jones, DT, Pentony, MM, Jones, D.T., Edwards, YJK, Lobley, A.E., Pentony, M.M., David T Jones, Yvonne JK Edwards, Lobley, AE, Anna E Lobley, Melissa M Pentony   +11 more
core   +1 more source

Auxin-regulated gene expression

Philosophical Transactions of the Royal Society of London. B, Biological Sciences, 1986
Abstract During the 1960s a wide range of studies provided an information base that led to the suggestion that auxin-regulated cell processes - especially cell elongation - may be mediated by auxin-regulated gene expression. Indirect evidence from our work, based on the influence of inhibitors of RNA synthesis (e.g. actinomycin D) and
J L, Key, P, Kroner, J, Walker, J C, Hong, T H, Ulrich, W M, Ainley, J S, Gantt, R T, Nagao   +7 more
openaire   +3 more sources

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Balancing noise and plasticity in gene expression

, 2011
Coupling the control of expression stochasticity (noise) with the capacity to expression change (plasticity) can constrain gene function and limit adaptation. Which factors contribute then to modulate this coupling?
Juan F. Poyatos, Djordje Bajic
core  

GSTCD and INTS12 Regulation and Expression in the Human Lung [PDF]

, 2013
Genome-Wide Association Study (GWAS) meta-analyses have identified a strong association signal for lung function, which maps to a region on 4q24 containing two oppositely transcribed genes: glutathione S-transferase, C-terminal domain containing (GSTCD ...
Swan, Caroline, Erik Melén (276082), Ma'en Obeidat, Hao Ke, S. Miller (3494552), Nelson, CP, I. Sayers (3494558), Henry, Amanda P., Probert, Kelly, C. Swan (7390268), Sayers, Ian, Miller Suzanne, K. Probert (7667498), Hodge, E, Maxime Lamontagne (116448), Ma’en Obeidat (460144), Ushey Kevin, Hao, Ke, Dirkje S Postma, Kevin Ushey (181019), Tobin, MD, Wain, LV, Amanda P. Henry (460148), Dirkje S. Postma (101740), Y. Bossé (7628753), Lamontagne, M, Miller, Suzanne, Obeidat Ma’en, Wain, Louise V., Melén Erik, María Soler Artigas (7603997), Caroline Swan (37264), Ceri E. Stewart (460151), Obeidat, Ma'en, Stewart, CE, E. Melén (3494549), Soler Artigas, María, Bossé, Y, Caroline Swan, Kelly Probert (460146), Nelson, Carl P., Nelson Carl P., Stewart Ceri E., Postma, Dirkje S., Lamontagne Maxime, Probert, K, Ceri E Stewart, Hao, K, Carl P Nelson, Hall Ian P., Erik Melén, Ke Hao, Postma Dirkje S., Artigas, Maria Soler, K. Hao (7628756), Billington Charlotte K., Kevin Ushey, Charlotte K. Billington (460147), D. S. Postma (3809164), M. Obeidat (7628729), María Soler Artigas (110124), Louise V. Wain (7588511), Martin D Tobin, Carl P. Nelson (460150), Ushey, Kevin, Ian Sayers, C. P. Nelson (7591670), Tobin Martin D., Ian P. Hall (110307), Hodge, Emily, Ian P Hall, Maxime Lamontagne, Louise V Wain, C. K. Billington (7667501), Emily Hodge (460149), Ke Hao (50181), Wain Louise V., Bossé Yohan, Sayers, I, Ushey, K, Hall, IP, Louise V. Wain (110260), Amanda P Henry, Emily Hodge, Artigas, MS, C. E. Stewart (7627559), Melen, Erik, E. Hodge (7643807), Billington, Charlotte K., Suzanne Miller, Obeidat, Ma�en, Henry Amanda P., Soler Artigas, Mar�a, Hodge Emily, Probert Kelly, Obeidat, M, Lamontagne, Maxime, Billington, CK, K. Ushey (7667507), Boss�, Yohan, Melén, E, A. P. Henry (7667504), Sayers Ian, Swan, C, Kelly Probert, Stewart, Ceri E., Obeidat, Ma’en, Ian Sayers (37266), Martin D. Tobin (7581161), Artigas María Soler, Henry, AP, Postma, DS, Yohan Bossé (69571), Hall, Ian P., Tobin, Martin D., Suzanne Miller (460145), Yohan Bossé, M. Lamontagne (7667510), Swan Caroline, Martin D. Tobin (110311), Mel�n, Erik, Miller, S, Charlotte K Billington, María Soler Artigas, Bosse, Yohan, I. P. Hall (7628774)   +125 more
core   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

rDNA Clusters Make Contact with Genes that Are Involved in Differentiation and Cancer and Change Contacts after Heat Shock Treatment

Cells, 2019
Human rDNA clusters form numerous contacts with different chromosomal regions as evidenced by chromosome conformation capture data. Heterochromatization of rDNA genes leads to heterochromatization in different chromosomal regions coupled with the ...
Nickolai A. Tchurikov, Daria M. Fedoseeva, Elena S. Klushevskaya, Ivan Y. Slovohotov, Vladimir R. Chechetkin, Yuri V. Kravatsky, Olga V. Kretova   +6 more
doaj   +1 more source