Results 41 to 50 of about 4,794,651 (300)

Comparative genetic, proteomic and phosphoproteomic analysis of C. elegans embryos with a focus on ham-1/STOX and pig-1/MELK in dopaminergic neuron development

Scientific Reports, 2017
Asymmetric cell divisions are required for cellular diversity and defects can lead to altered daughter cell fates and numbers. In a genetic screen for C.
Sarah-Lena Offenburger, Dalila Bensaddek, Alejandro Brenes Murillo, Angus I. Lamond, Anton Gartner   +4 more
doaj   +1 more source

The role of DDK and Treslin–MTBP in coordinating replication licensing and pre-initiation complex formation

Open Biology, 2021
Treslin/Ticrr is required for the initiation of DNA replication and binds to MTBP (Mdm2 Binding Protein). Here, we show that in Xenopus egg extract, MTBP forms an elongated tetramer with Treslin containing two molecules of each protein.
Ilaria Volpi, Peter J. Gillespie, Gaganmeet Singh Chadha, J. Julian Blow   +3 more
doaj   +1 more source

Administration of Insurance Rate Regulatory Laws [PDF]

, 1950
microRNAs (miRNAs) are key posttranscriptional regulators of gene expression. In the present study, regulation of tumor-suppressor gene D-glucuronyl C5-epimerase (GLCE) by miRNA-218 was investigated. Significant downregulation of miRNA-218 expression was
Ernberg, Ingemar, Grigorieva, Elvira V, Kashuba, Vladimir I, Mostovich, Luydmila A, Prudnikova, Tatiana Y, Zabarovsky, Eugene R   +5 more
core   +3 more sources

A role for p53 in telomere protection

Molecular & Cellular Oncology, 2017
Telomeres cap the ends of chromosomes and are crucial for genome stability. The p53 protein (TP53) is a vital tumor suppressor, activating the transcription of numerous genes in response to cell stress.
Stephen Tutton, Paul M. Lieberman
doaj   +1 more source

miRNAs as Regulators of Antidiabetic Effects of Fucoidans [PDF]

, 2019
open access articleDiabetes mellitus is a metabolic disease with a high mortality rate worldwide. MicroRNAs (miRNAs), and other small noncoding RNAs, serve as endogenous gene regulators through binding to specific sequences in RNA and modifying gene ...
Arroo, R. R. J., El-Seed, Hesham, Ismail, Amin, Lai, Shanshan, Liu, Dan, Wu, Desheng, Xiao, Jianbo, Zhao, Chao, Zou, Xiaobo   +8 more
core   +1 more source

The human lncRNA LINC-PINT inhibits tumor cell invasion through a highly conserved sequence element

Genome Biology, 2017
Background It is now obvious that the majority of cellular transcripts do not code for proteins, and a significant subset of them are long non-coding RNAs (lncRNAs).
Oskar Marín-Béjar, Aina M. Mas, Jovanna González, Dannys Martinez, Alejandro Athie, Xabier Morales, Mikel Galduroz, Ivan Raimondi, Elena Grossi, Shuling Guo, Ana Rouzaut, Igor Ulitsky, Maite Huarte   +12 more
doaj   +1 more source

Dynamics of Whole-Genome Contacts of Nucleoli in Drosophila Cells Suggests a Role for rDNA Genes in Global Epigenetic Regulation

Cells, 2020
Chromosomes are organized into 3D structures that are important for the regulation of gene expression and differentiation. Important role in formation of inter-chromosome contacts play rDNA clusters that make up nucleoli. In the course of differentiation,
Nickolai A. Tchurikov, Elena S. Klushevskaya, Daria M. Fedoseeva, Ildar R. Alembekov, Galina I. Kravatskaya, Vladimir R. Chechetkin, Yuri V. Kravatsky, Olga V. Kretova   +7 more
doaj   +1 more source

Characterization of tissue-specific differential DNA methylation suggests distinct modes of positive and negative gene expression regulation

BMC Genomics, 2015
DNA methylation plays an important role in regulating gene expression during many biological processes. However, the mechanism of DNA-methylation-dependent gene regulation is not fully understood.
Jun Wan, V. F. Oliver, Guohua Wang, Heng Zhu, D. Zack, S. Merbs, Jiang Qian   +6 more
semanticscholar   +1 more source

Regulated gene expression in methanogens [PDF]

FEMS Microbiology Reviews, 1994
Methanogens form a very large and diverse group of microorganisms within the domain of the Archaea. Energy for their growth is obtained by the reduction of a variety of substrates into methane. Several genes, coding for enzymes involved in methanogenesis or in the central metabolism have been cloned and studied.
openaire   +3 more sources

Stochastic modeling of regulation of gene expression by multiple small RNAs

, 2011
A wealth of new research has highlighted the critical roles of small RNAs (sRNAs) in diverse processes such as quorum sensing and cellular responses to stress.
Baker, Charles, Jia, Tao, Kulkarni, Rahul V.   +2 more
core   +1 more source