Results 51 to 60 of about 2,494,853 (253)

miRNA/phasiRNA mediated regulation of plant defense response against P. syringae [PDF]

, 2018
Gene silencing is a mechanism of regulation of gene expression where the small RNAs (sRNAs) are key components for giving specificity to the system. In plants, two main types of noncoding small RNA molecules have been found: microRNAs (miRNAs) and small ...
Del Espino Pérez, Ángel, López-Márquez, Diego, López-Pagán, Nieves, Rodriguez-Bejarano, Eduardo, Rodríguez-Negrete, Edgar A., Rubio-Somoza, Ignacio, Ruiz-Albert, Francisco Javier, Zumaquero, A.   +7 more
core  

Identification of novel small molecule inhibitors of ETS transcription factors

FEBS Letters, EarlyView.
ETS transcription factors play an essential role in tumourigenesis and are indispensable for sprouting angiogenesis, a hallmark of cancer, which fuels tumour expansion and dissemination. Thus, targeting ETS transcription factor function could represent an effective, multifaceted strategy to block tumour growth. The evolutionarily conserved E‐Twenty‐Six
Shaima Abdalla, Zary Forghany, Jin Ma, Johan G. Hollander, Ruta Nachane, Karoly Szuhai, Pancras C. W. Hogendoorn, Peter ten Dijke, Dipen Shah, David A. Baker   +9 more
wiley   +1 more source

Administration of Insurance Rate Regulatory Laws [PDF]

, 1950
microRNAs (miRNAs) are key posttranscriptional regulators of gene expression. In the present study, regulation of tumor-suppressor gene D-glucuronyl C5-epimerase (GLCE) by miRNA-218 was investigated. Significant downregulation of miRNA-218 expression was
Ernberg, Ingemar, Grigorieva, Elvira V, Kashuba, Vladimir I, Mostovich, Luydmila A, Prudnikova, Tatiana Y, Zabarovsky, Eugene R   +5 more
core   +3 more sources

The cytoskeletal control of B cell receptor and integrin signaling in normal B cells and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
wiley   +1 more source

Discovering transcriptional modules by Bayesian data integration [PDF]

, 2010
Motivation: We present a method for directly inferring transcriptional modules (TMs) by integrating gene expression and transcription factor binding (ChIP-chip) data.
Antoniak, Bar-Joseph, Bernard J. de la Cruz, Bähler, Cho, Dahl, Datta, David L. Wild, Eisen, Falcon, Ferguson, Fritsch, Gasch, Gerber, Geweke, Harbison, Ideker, Ihmels, Jim E. Griffin, Kundaje, Lee, Liu, Liu, Medvedovic, Medvedovic, Qin, Rasmussen, Rasmussen, Reid, Richard S. Savage, Savage, Segal, Segal, Teh, Teh, Wild, Yao, Yeung, Zoubin Ghahramani   +38 more
core   +2 more sources

Social context prevents heat hormetic effects against mutagens during fish development

FEBS Letters, EarlyView.
This study shows that sublethal heat stress protects fish embryos against ultraviolet radiation, a concept known as ‘hormesis’. However, chemical stress transmission between fish embryos negates this protective effect. By providing evidence for the mechanistic molecular basis of heat stress hormesis and interindividual stress communication, this study ...
Lauric Feugere, Claudio Silva De Freitas, Adam Bates, Kenneth B. Storey, Pedro Beltran‐Alvarez, Katharina C. Wollenberg Valero   +5 more
wiley   +1 more source

Dynamic Interpretation of Hedgehog Signaling in the Drosophila Wing Disc [PDF]

, 2009
Morphogens are classically defined as molecules that control patterning by acting at a distance to regulate gene expression in a concentration-dependent manner.
A Casali, A Eldar, A Gonzalez, A Jazwinska, A Kicheva, Angelike Stathopoulos, B Biehs, B. D Harfe, C Han, C Ma, D Panakova, E Dessaud, F Hsiung, G Drossopoulou, H Meinhardt, H Nakagoshi, H Strutt, J Capdevila, J Cooke, J Hepker, J Jaeger, J Jeong, J Jia, J Jiang, J Lewis, J Taipale, J. B Gurdon, J. B Gurdon, J. F de Celis, J. L Mullor, J. L Mullor, K Lai, K Saha, K. S Ho, K. V Gunbin, L Wolpert, M Golembo, M Strigini, M Vervoort, Marcos Nahmad, Matthew P. Scott, N Denef, N Methot, N Methot, P. T Chuang, R Burke, R. L Johnson, S Apionishev, S Bergmann, S. S Blair, T Tabata, V. F Su, Y Chen, Z Chamoun   +53 more
core   +4 more sources

miRNA‐29 regulates epidermal and mesenchymal functions in skin repair

FEBS Letters, EarlyView.
miRNA‐29 inhibits cell‐to‐cell and cell‐to‐matrix adhesion by silencing mRNA targets. Adhesion is controlled by complex interactions between many types of molecules coded by mRNAs. This is crucial for keeping together the layers of the skin and for regenerating the skin after wounding.
Lalitha Thiagarajan, Rosa Sanchez‐Alvarez, Chiho Kambara, Poojitha Rajasekar, Yuluang Wang, François Halloy, Jonathan Hall, Hans‐Jürgen Stark, Iris Martin, Petra Boukamp, Svitlana Kurinna   +10 more
wiley   +1 more source

Transcription of a 5' extended mRNA isoform directs dynamic chromatin changes and interference of a downstream promoter. [PDF]

, 2017
Cell differentiation programs require dynamic regulation of gene expression. During meiotic prophase in Saccharomyces cerevisiae, expression of the kinetochore complex subunit Ndc80 is downregulated by a 5' extended long undecoded NDC80 transcript ...
Chen, Jingxun, Chia, Minghao, Jorgensen, Victoria, Spedale, Gianpiero, Tresenrider, Amy, van Werven, Folkert Jacobus, Ünal, Elçin   +6 more
core   +2 more sources

Spot‐14 and its paralog Spot‐14R regulate expression of metabolic and thermogenic pathway genes in murine brown and beige adipocytes

FEBS Letters, EarlyView.
Spot‐14 and Spot‐14R play distinct roles in regulating metabolism in brown and beige adipocytes. While both influence lipid and glucose pathways, Spot‐14 uniquely controls thermogenic gene expression. This dual regulation balances energy storage and heat production, highlighting potential therapeutic targets for obesity and metabolic disorders. Spot 14
Lidia Itzel Castro‐Rodríguez, Cristina Velez‐delValle, Claudia Patricia Hernández‐Mosqueira, Walid Kuri‐Harcuch   +3 more
wiley   +1 more source