Results 1 to 10 of about 1,687,286 (315)
Biomolecular Concepts, 2014 MDM2 is an oncoprotein that blocks p53 tumor suppressor-mediated transcriptional transactivation, escorts p53 from the cell nucleus to the cytoplasm, and polyubiquitylates p53.
Mendoza Michael +2 more
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Journal of Lipid Research, 2002 Development of the lipase gene family spans the change in science that witnessed the birth of contemporary techniques of molecular biology. Amino acid sequencing of enzymes gave way to cDNA cloning and gene organization, augmented by in vitro expression ...
Howard Wong, Michael C. Schotz
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Molecular Therapy: Methods & Clinical Development, 2021 Despite significant advances in cystic fibrosis (CF) treatments, a one-time treatment for this life-shortening disease remains elusive. Stable complementation of the disease-causing mutation with a normal copy of the CF transmembrane conductance ...
Laura I. Marquez Loza +6 more
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Retinoblastoma family genes [PDF]
Oncogene, 2006 The retinoblastoma gene Rb was the first tumor suppressor gene cloned, and it is well known as a negative regulator of the cell cycle through its ability to bind the transcription factor E2F and repress transcription of genes required for S phase. Although over 100 other proteins have been reported to interact with Rb, in most cases these interactions ...
W, Du, J, Pogoriler
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Lentiviral vectors transduce lung stem cells without disrupting plasticity
Molecular Therapy: Nucleic Acids, 2021 Life-long expression of a gene therapy agent likely requires targeting stem cells. Here we ask the question: does viral vector transduction or ectopic expression of a therapeutic transgene preclude airway stem cell function?
Ashley L. Cooney +4 more
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Molecular evolution and expression divergence of three key Met biosynthetic genes in plants: CGS, HMT and MMT [PDF]
PeerJ, 2018 Methionine (Met) is an essential sulfur-containing amino acid in animals. Cereal and legume crops with limiting levels of Met represent the major food and feed sources for animals.
Man Zhao +6 more
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Gene Cluster Statistics with Gene Families [PDF]
Molecular Biology and Evolution, 2009 Identifying genomic regions that descended from a common ancestor is important for understanding the function and evolution of genomes. In distantly related genomes, clusters of homologous gene pairs are evidence of candidate homologous regions. Demonstrating the statistical significance of such "gene clusters" is an essential component of comparative ...
Raghupathy, Narayanan, Durand, Dannie
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Frontiers in Genetics, 2023 The dirigent (DIR) gene is a key player in environmental stress response and has been identified in many multidimensional tube plant species. However, there are few studies on the StDIR gene in potato. In this study, we used genome-wide identification to
Wenqi Jia +5 more
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Intratracheal aerosolization of viral vectors to newborn pig airways
BioTechniques, 2020 Gene therapy for airway diseases requires efficient delivery of nucleic acids to the airways. In small animal models, gene delivery reagents are commonly delivered as a bolus dose.
Ashley L Cooney, Patrick L Sinn
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Frontiers in Plant Science, 2022 Lipoxygenases (LOXs) are a gene family of nonheme iron-containing dioxygenases that play important roles in plant development and defense responses. To date, a comprehensive analysis of LOX genes and their biological functions in response to abiotic ...
Yifei Mou +7 more
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