Results 101 to 110 of about 7,504,063 (305)

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Journal of the Malta College of Family Doctors : volume 5 : issue 3 [PDF]

, 2016
MALLIA, P. - Graduation, specialisation and future initiatives -- GRECH, A., AXIAK, S., & GERADA, C. - The interphase between family medicine and mental health -- PULLICINO, G., PAVIA, J., ZINTILIS, S., FRANCALANZA, S., SCIORTINO, P., & SCIORTINO, P. -
Mallia, Pierre, Malta College of Family Doctors   +1 more
core  

‘Guide and Prejudice’— How Argonautes recognize targets across domains of life

FEBS Letters, EarlyView.
Argonaute proteins use short nucleic‐acid guides to locate and regulate specific targets across all domains of life. Despite striking diversity—from human gene silencing to bacterial immune defence—all Argonautes share a conserved three‐stage recognition logic: guide‐directed sampling, progressive target pairing with a conformational checkpoint and ...
Jack P. K. Bravo
wiley   +1 more source

Grid Trust Model Based on Family Gene

工程科学与技术, 2006
:In the light of the deficiencies of current grid trust models based on PKI (Public Key Infrastructure), such as ambiguity certificate information and complicated identification process,a novel grid trust model based on Family Gene (FG) model was ...
doaj  

Identification and expression profiling of SmGATA genes family involved in response to light and phytohormones in eggplant

Frontiers in Plant Science
GATA proteins are transcription factors of zinc finger proteins, which play an important role in plant growth development and abiotic stress. However, there have been no identification or systematic studies of the GATA gene family in eggplant.
Yanyan Wang, Xinyun Li, Yunrong Mo, Caiqian Jiang, Ying Zhou, Jingyi Hu, Youling Zhang, Junheng Lv, Kai Zhao, Zhenya Lu   +9 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Identification and expression profiling of GAPDH family genes involved in response to Sclerotinia sclerotiorum infection and phytohormones in Brassica napus

Frontiers in Plant Science
Glyceraldehyde 3-phosphate dehydrogenase (GAPDH) is a crucial enzyme in glycolysis, an essential metabolic pathway for carbohydrate metabolism across all living organisms. Recent research indicates that phosphorylating GAPDH exhibits various moonlighting
Jing Xu, Jing Xu, Rongbo Wang, Xiong Zhang, Wei Zhuang, Yang Zhang, Jianxin Lin, Penglin Zhan, Shanhu Chen, Heding Lu, Airong Wang, Changjian Liao   +11 more
doaj   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Genome-Wide Identification, Characterization, and Expression Profile of SWEETs Gene Family in Grapevine (Vitis vinifera L.)

Horticulturae
SWEET (Sugars Will Eventually Be Exported Transporter) proteins, identified recently as a novel class of sugar transporters, play pivotal roles in the transport and distribution of photosynthetic products in plants.
Linjing Zhong, Shuya Xu, Chenchen Song, Ning Zhao, Zhiqi Yang, Yanxiang Liu, Xiaoyue Cui, Jianxia Zhang, Zhi Li, Xiping Wang, Min Gao   +10 more
doaj   +1 more source