Results 241 to 250 of about 3,050,344 (306)

Ketogenic Diet as an Epigenetic Therapy in SETD1B‐Related Epilepsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Histone lysine methyltransferases such as SETD1B regulate chromatin structure and gene transcription. Ketone bodies, including butyrate, act as histone deacetylase inhibitors. We report a 4‐year‐old boy with SETD1B‐related absence epilepsy, refractory to conventional medications, who achieved sustained > 90% seizure reduction on the Modified ...
Erica Tsang, Brian S. Gloss, Jessica P. Hayes, Andrew J. A. Holland, Manoj P. Menezes, Joceline A. Branson, Shekeeb S. Mohammad, Jingya J. Yan, Shrujna Patel, Velda X. Han, Russell C. Dale   +10 more
wiley   +1 more source

Innate Immune Reprogramming Mediated by Endogenous Retroelement Dysregulation Drives Multiple Sclerosis Progression

Annals of Clinical and Translational Neurology, EarlyView.
Epigenetic reprogramming in hematopoietic stem and progenitor cells (HSPCs) and downstream myeloid cells, mediated by H3.3 downregulation and endogenous retroelement (ERE) overexpression, contributes to the progression of multiple sclerosis (MS). ABSTRACT Background Skewed myelopoiesis in the bone marrow has been identified as a key driver of multiple ...
Li‐Mei Xiao, Qiu‐Ping Zhao, Run‐Yun Li, Wei Chen, Huan‐Huan Song, Wan‐Jin Chen, Ying Fu   +6 more
wiley   +1 more source

Analysis of the aspartic protease gene family in <i>Nicotiana benthamiana</i> and its application in recombinant protein expression. [PDF]

Front Plant Sci
Li Y, Liu T, Zhu L, Wu R, Liu Y, Zhou H, Guo W, Zhang S, Akher SA, Piao H, Zhang J, Liang K, Zhao Z, Guo Y, Jin Z, Zhang Z.   +15 more
europepmc   +1 more source

A Depolarizing Leak in Sodium Bicarbonate Cotransporter NBCe1 Causes Brain Edema

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives SLC4A4 encodes electrogenic sodium bicarbonate cotransporter NBCe1, prominently expressed in kidney and brain. Recessive loss‐of‐function variants in SLC4A4 cause proximal renal tubular acidosis, no brain edema. In the brain, NBCe1 is expressed by astrocytes, where it regulates pH and mediates astrocyte volume changes.
Quinty Bisseling, Mark D. Parker, Sven Kerst, Richard A. Pasternack, Jacob Tondreau, Marjolein Breur, Gemma M. van Rooijen‐van Leeuwen, Davide Tonduti, Ettore Salsano, Alejandra Darling, Joanna A. E. van Wijk, Susanna Törnroth‐Horsefield, Marianna Bugiani, Petra J. W. Pouwels, Quinten Waisfisz, Marjo S. van der Knaap, Rogier Min   +16 more
wiley   +1 more source

Genome-wide identification and characterization of CaM and CML gene family in chickpea (Cicer arietinum L.). [PDF]

Sci Rep
Swain B, Gupta P, Yadav D.
europepmc   +1 more source

Evolutionary conservation and enhanced basal immunity of the ZmNBS gene family in maize. [PDF]

Front Plant Sci
Xu Z, Feng L.
europepmc   +1 more source

Transcriptome-based identification of the WRKY gene family in Polygala tenuifolia Willd. and their response to cold stress. [PDF]

BMC Plant Biol
Liu J, Wang Q, Wang Z, Han S, Tuohetuohuli D, Liu S, Zhang H.   +6 more
europepmc   +1 more source

Genome-wide identification of the ATL gene family and their expression analysis in sweetpotato and its two diploid relatives. [PDF]

BMC Plant Biol
Liu R, Yang Y, Gao S, Zhang H, Zhao N, He S, Liu Q, Zhai H.   +7 more
europepmc   +1 more source