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The rat prolactin gene family locus: species-specific gene family expansion
Mammalian Genome, 2006In the rat there is a large family of paralogous genes related to prolactin (PRL). Members of the PRL family are expressed in cell- and temporal-specific patterns in the anterior pituitary, uterus, and placenta. An overriding feature of the PRL family is its association with pregnancy.
S M Khorshed, Alam +4 more
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International Journal of Molecular Medicine, 2002
GIPC1/GIPC/RGS19IP1, GIPC2, and GIPC3 genes constitute the human GIPC gene family. GIPC1 and GIPC2 show 62.0% total-amino-acid identity. GIPC1 and GIPC3 show 59.9% total-amino-acid identity. GIPC2 and GIPC3 show 55.3% total-amino-acid identity. GIPCs are proteins with central PDZ domain and GIPC homology (GH1 and GH2) domains. PDZ, GH1, and GH2 domains
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GIPC1/GIPC/RGS19IP1, GIPC2, and GIPC3 genes constitute the human GIPC gene family. GIPC1 and GIPC2 show 62.0% total-amino-acid identity. GIPC1 and GIPC3 show 59.9% total-amino-acid identity. GIPC2 and GIPC3 show 55.3% total-amino-acid identity. GIPCs are proteins with central PDZ domain and GIPC homology (GH1 and GH2) domains. PDZ, GH1, and GH2 domains
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Theoretical Population Biology, 1990
Theories and facts of gene family evolution are reviewed. Concerted evolution is commonly observed for gene families which originated a long time ago, however there are many different types of multigene families, from uniform to diverse. The rate of homogenization by unequal crossing-over, gene conversion, etc. has been evolutionarily adjusted for each
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Theories and facts of gene family evolution are reviewed. Concerted evolution is commonly observed for gene families which originated a long time ago, however there are many different types of multigene families, from uniform to diverse. The rate of homogenization by unequal crossing-over, gene conversion, etc. has been evolutionarily adjusted for each
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Gene Structure and Gene Families
2019Approaches for the discovery of protein-coding genes were described in detail in Chap. 3. These included EST sequencing, RNA-seq, and full genome sequencing. Raw DNA sequences generated by these approaches are assembled into sets that are assumed to come from a single genetic locus. These are often called unigene sets.
David B. Neale, Nicholas C. Wheeler
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Adaptive evolution of genes and gene families
Current Opinion in Genetics & Development, 2003The huge influx of genomic sequence and new statistical methods is making the discovery of genes subjected to adaptive evolution increasingly common. The use of comparative genomics to identify adaptive evolution is resulting in predictions of functionally important genes and gene regions.
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Cancer epigenetics in clinical practice
Ca-A Cancer Journal for Clinicians, 2023Veronica Davalos, Manel Esteller
exaly
Genetic testing in prostate cancer management: Considerations informing primary care
Ca-A Cancer Journal for Clinicians, 2022Veda N Giri +2 more
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