Results 61 to 70 of about 11,121,866 (385)

FoxO1 signaling in B cell malignancies and its therapeutic targeting

FEBS Letters, EarlyView.
FoxO1 has context‐specific tumor suppressor or oncogenic character in myeloid and B cell malignancies. This includes tumor‐promoting properties such as stemness maintenance and DNA damage tolerance in acute leukemias, or regulation of cell proliferation and survival, or migration in mature B cell malignancies.
Krystof Hlavac, Petra Pavelkova, Laura Ondrisova, Marek Mraz   +3 more
wiley   +1 more source

Hsf transcription factor gene family in peanut (Arachis hypogaea L.): genome-wide characterization and expression analysis under drought and salt stresses

Frontiers in Plant Science, 2023
Heat shock transcription factors (Hsfs) play important roles in plant developmental regulations and various stress responses. In present study, 46 Hsf genes in peanut (AhHsf) were identified and analyzed. The 46 AhHsf genes were classed into three groups
Qi Wang, Zhenbiao Zhang, Cun Guo, Xiaobo Zhao, Zhiyuan Li, Yifei Mou, Quanxi Sun, Juan Wang, Cuiling Yuan, Chunjuan Li, Ping Cong, Shihua Shan   +11 more
doaj   +1 more source

The immunological interface: dendritic cells as key regulators in metabolic dysfunction‐associated steatotic liver disease

FEBS Letters, EarlyView.
Metabolic dysfunction‐associated steatotic liver disease (MASLD) affects nearly one‐third of the global population and poses a significant risk of progression to cirrhosis or liver cancer. Here, we discuss the roles of hepatic dendritic cell subtypes in MASLD, highlighting their distinct contributions to disease initiation and progression, and their ...
Camilla Klaimi, WanTing Kong, Camille Blériot, Joel T. Haas   +3 more
wiley   +1 more source

Genome-wide identification of the PFK gene family and their expression analysis in Quercus rubra

Frontiers in Genetics, 2023
The glycolytic pathway involves phosphofructokinase (PFK), a rate-limiting enzyme that catalyzes the phosphorylation of fructose-6-phosphate. In plants, the two PFK members are ATP-dependent phosphofructokinase (PFK) and pyrophosphate-fructose-6 ...
Tae-Lim Kim, Hyemin Lim, Michael Immanuel Jesse Denison, Sathishkumar Natarajan, Changyoung Oh   +4 more
doaj   +1 more source

Update on the Kelch-like (KLHL) gene family

Human Genomics, 2013
The Kelch-like (KLHL) gene family encodes a group of proteins that generally possess a BTB/POZ domain, a BACK domain, and five to six Kelch motifs. BTB domains facilitate protein binding and dimerization.
Bajinder S Dhanoa, T. Cogliati, Akhila G. Satish, E. Bruford, J. Friedman   +4 more
semanticscholar   +1 more source

The Evolution of Mammalian Gene Families

PLoS ONE, 2006
Gene families are groups of homologous genes that are likely to have highly similar functions. Differences in family size due to lineage-specific gene duplication and gene loss may provide clues to the evolutionary forces that have shaped mammalian genomes. Here we analyze the gene families contained within the whole genomes of human, chimpanzee, mouse,
Demuth, Jeffery P, De Bie, Tijl, Stajich, Jason E, Cristianini, Nello, Hahn, Matthew W   +4 more
openaire   +7 more sources

Unraveling Mycobacterium tuberculosis acid resistance and pH homeostasis mechanisms

FEBS Letters, EarlyView.
Mycobacterium tuberculosis exhibits a remarkable resilience to acid stress. In this Review, we discuss some of the molecular mechanisms and metabolic pathways used by the tubercle bacilli to adapt and resist host‐mediated acid stress. Mycobacterium tuberculosis (Mtb) is a successful pathogen that has developed a variety of strategies to survive and ...
Janïs Laudouze, Stéphane Canaan, Alexandre Gouzy, Pierre Santucci   +3 more
wiley   +1 more source

Genome-wide identification and expression analysis of lipoxygenase genes in Tartary buckwheat

Biotechnology & Biotechnological Equipment, 2020
Lipoxygenases (LOXs; EC1.13.11.12) are widely involved in plant growth, development, maturation, senescence and stress resistance. LOXs have been studied in many crop species but not in Tartary buckwheat [Fagopyrum tataricum (L.) Gaertn.].
Qiqi Ji, Tianyuan Zhang, Dong Zhang, Shiming Lv, Aijuan Tan   +4 more
doaj   +1 more source

Bioinformatics Analysis of WRKY Family Genes in Flax (Linum usitatissimum)

Life, 2023
WRKY gene family is one of the largest transcription factor families involved in various physiological processes of plants. Flax (Linum usitatissimum) is an important stem fiber crop, and it is also an economically important crop in natural fiber and ...
Xia An, Qin Liu, Hui Jiang, Guoyun Dong, Danqing Tian, Xiahong Luo, Changli Chen, Wenlue Li, Tingting Liu, Lina Zou, Jinyao Ying, Huaping Zhou, Xuan Zhu, Xiaoyan Chen   +13 more
doaj   +1 more source

Gene family amplification facilitates adaptation in freshwater Unionid bivalve Megalonaias nervosa [PDF]

, 2020
As organisms are faced with intense rapidly changing selective pressures, new genetic material is required to facilitate adaptation. Among sources of genetic novelty, gene duplications and transposable elements (TEs) offer new genes or new regulatory patterns that can facilitate evolutionary change.
arxiv   +1 more source