Results 81 to 90 of about 1,089,429 (263)
Science, 2012 Ecology![Figure][1] CREDIT: © PETE MCBRIDE/NATIONAL GEOGRAPHIC SOCIETY/CORBIS Antibiotic resistance is becoming an urgent problem. We point one finger at lax medication sales, and another at livestock husbandry, but there is also an ancient background signal of antibiotic resistance, in part stemming from the natural functions of these molecules in ...
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Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
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Nature, 1993 Species Evolution: The Role of Chromosome Change. By Max King. Cambridge University Press: 1993. Pp. 336. £40, $59.95.
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Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
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Aquatic Insects in Eastern Australia: A Window on Ecology and Evolution of Dispersal in Streams
Insects, 2011 Studies of connectivity of natural populations are often conducted at different timescales. Studies that focus on contemporary timescales ask questions about dispersal abilities and dispersal behavior of their study species.
Alison J. McLean +3 more
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Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
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Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
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Assessment of diversity in Quercus brantii populations of the north Zagros forests using morphological and molecular ISSR and IRAP markers [PDF]
مجله جنگل ایران, 2015 In this study, the intra- and inter-population genetic diversities of 125 genotypes representing nine populations of Quercus brantii from North-Zagros forests were studied using leaf morphological characteristics, inter simple sequence repeats (ISSR ...
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Ecology and EvolutionUnderstanding dispersal potential, or the probability a species will move a given distance, under different environmental conditions is essential to predicting species' ability to move across the landscape and track shifting ecological niches.
Lauren L. Sullivan +4 more
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ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
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