Results 81 to 90 of about 1,078,640 (312)

Beyond Roadkill, Radiotracking, Recapture and FST - a Review of Some Genetic Methods to Improve Understanding of the Influence of Roads on Wildlife

Ecology and Society, 2010
Habitat fragmentation continues to occur despite increasing evidence of its adverse effects on ecosystems. One of the major detrimental effects of roads and traffic is the creation of barriers or filters to the movement of wildlife, ultimately ...
Jody M. Simmons, Paul Sunnucks, Andrea C. Taylor, Rodney van der Ree   +3 more
doaj   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Inhibition of stimulated meningeal blood flow by a calcitonin gene‐related peptide binding mirror‐image RNA oligonucleotide [PDF]

, 2006
Thomas Denekas, Markus Tröltzsch, Axel Vater, Sven Klußmann, Karl Meßlinger   +4 more
openalex   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Amplified fragment length polymorphism fingerprints support limited gene flow among social spider populations [PDF]

, 2009
Deborah R. Smith, SANDER VAN RIJN, Joh R. Henschel, Trine Bilde, Yael Lubin   +4 more
openalex   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Development of New Chloroplast Microsatellites for Pinus gerardiana and their Application in Genetic Diversity Analyses

Ecology and Evolution
Chloroplast DNA (cpDNA) is a valuable tool for studying plant population genetics and gene flow by pollen in conifers due to their paternal inheritance, particularly through the application of chloroplast DNA microsatellite markers (cpSSRs).
Sayed Jalal Moosavi, Markus Mueller, Oliver Gailing   +2 more
doaj   +1 more source

Rivers of Gene Flow [PDF]

Science, 2012
Ecology![Figure][1] CREDIT: © PETE MCBRIDE/NATIONAL GEOGRAPHIC SOCIETY/CORBIS Antibiotic resistance is becoming an urgent problem. We point one finger at lax medication sales, and another at livestock husbandry, but there is also an ancient background signal of antibiotic resistance, in part stemming from the natural functions of these molecules in ...
openaire   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

THE IMPACTS AND ADAPTIONS OF TRANSGENIC PLANTS IN AGROECOSYSTEMS

Ekonomika Poljoprivrede (1979), 2006
There is a multitude of concerns about the impact of genetically modified crops (GMCs) on the environment. The main important enviromental assessment of GM crops are putative invasiveness, vertical and/or horizontal gene flow, other ecological ...
Jelena Bošković, Vasilije Isajev, Momčilo Bošković, Zdravko Hojka, Željana Prijić, Jeremija Simić   +5 more
doaj