Results 101 to 110 of about 1,189,577 (306)

Estimating parameters of speciation models based on refined summaries of the joint site-frequency spectrum [PDF]

, 2011
Understanding the processes and conditions under which populations diverge to give rise to distinct species is a central question in evolutionary biology.
Rose, Laura E., Peter Pfaffelhuber, Pfaffelhuber, P., Naduvilezhath, L., Laura E Rose, Thomas Städler, Laura E. Rose, Rose, L., Aurélien Tellier, Metzler, D., Haubold, Bernhard, Stephan, Wolfgang, Bernhard Haubold, Tellier, A., Lisha Naduvilezhath, Städler, T., Pfaffelhuber, Peter, Naduvilezhath, Lisha, Tellier, Aurélien, Haubold, B., Stephan, W., Städler, Thomas, Metzler, Dirk, Wolfgang Stephan, Dirk Metzler   +24 more
core   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Component parts of the World Heat Flow Data Collection

, 1972
Component parts of the World Heat Flow Data ...
Gene Simmons (7991591), Simmons, Gene, A J Erickson (7992377), Erickson, A J, Helsley, Charles E, Charles E Helsley (7992512)   +5 more
core   +2 more sources

Adaptation despite gene flow? Low recombination helps

, 2017
About 15,000 years earlier, the Northern half of Europe and North America was buried under a few kilometres of ice. Since then, many organisms have colonized and rapidly adapted to the new, vacant habitats.
Marques, David Alexander, David A. Marques   +1 more
core   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Geographical variation and gene flow in the eucalyptus defoliating beetle Chrysophtharta bimaculata (Coleoptera: Chrysomelidae)

, 1997
1. Management of the eucalyptus defoliating beetle Chrysophtharta bimaculata is considered essential to the economic sustainability of timber production in Tasmanian eucalyptus plantations. This study examined population subdivision and host associations
Lange, Corinna L., Clarke, Anthony R., Congdon, Bradley C., Congdon, B.C., Lange, C.L.   +4 more
core   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Isolation and characterization of eleven polymorphic microsatellite markers from the beneficial carabid beetle, Poecilus cupreus (Coleoptera: Carabidae), and genetic structuring among three populations from western France

European Journal of Entomology, 2014
Poecilus cupreus (L.) (Coleoptera: Carabidae) is a typical polyphagous predator species on arable lands. In this study, 11 polymorphic microsatellite markers were developed from genomic DNA of P. cupreus.
Ronan MARREC, Stéphanie RUAULT, Cécile RIBOUT, Manuel PLANTEGENEST, Bertrand GAUFFRE   +4 more
doaj   +1 more source

Study protocol: a randomised controlled trial investigating the effect of exercise training on peripheral blood gene expression in patients with stable angina [PDF]

, 2010
Background: Exercise training has been shown to reduce angina and promote collateral vessel development in patients with coronary artery disease. However, the mechanism whereby exercise exerts these beneficial effects is unclear.
David C Crossman, Tew, G.A., Chico, Timothy, Tew, Garry, Bourke, Liam, John M Saxton, Tew, Garry A., Milo, M., Saxton, John, Liam Bourke, Garry A Tew, Saxton, John M, Saxton, J.M., Milo, Marta, Crossman, D.C., Chico, Timothy J. A., Marta Milo, Saxton, John M., Crossman, David C, Chico, Timothy JA, Chico, TJA, Crossman, David C., Saxton, JM, Milo, M, Crossman, DC, Crossman, David, Timothy JA Chico, Chico, T.J.A., Bourke, L.   +28 more
core   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source