Results 61 to 70 of about 1,168,362 (261)

GENE FLOW AND GENETIC DIFFERENTIATION [PDF]

Genetics, 1974
ABSTRACT A brief analysis is presented for the effects of gene flow upon genetic differentiation within and between populations generated by mutation and drift. Previous results obtained with the "island" model are developed into a form that lends itself to biological interpretation.
openaire   +2 more sources

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Genome-wide detection of fine-scale population stratification and long-distance dispersal of the Chinese mitten crab (Eriocheir sinensis)

Animal Cells and Systems
Understanding the population genetic structure of marine decapods is essential for their effective conservation and management, particularly for species like the Chinese mitten crab (Eriocheir sinensis), which exhibits a complex life cycle and high ...
Jibom Jung, Mijin Park, Donghee Kim, Hyungmin Moon, Meijun Tang, Xugan Wu, Seok Hyun Lee, Jongwoo Jung, Choongwon Jeong   +8 more
doaj   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Rare Alleles as Indicators of Gene Flow [PDF]

Evolution, 1985
A. method for estimating the average level of gene flow in a subdivided population, as measured by the average number of migrants exchanged between local populations, Nm, is presented. The results from a computer simulation model show that the logarithm of Nm is approximately linearly related to the logarithm of the average frequency of private alleles,
openaire   +2 more sources

Human Fragmentation Effects Are Genetically Detectable After 6 Years in an Island‐Endemic Plant

Ecology and Evolution
Anthropogenic disturbances have long been acknowledged to be one of the primary threats to biodiversity worldwide; however, little is still understood about how human‐built infrastructure affects gene flow and phylogeographic structure of plants.
Wen‐Ting Jin, Shao‐Jun Ling, Myong Gi Chung, Mi Yoon Chung, Jordi López‐Pujol, Ming‐Xun Ren   +5 more
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Restricted Dispersal in the Late Successional Forest Tree Species Nothofagus Pumilio: Consequences Under Global Change

Ecology and Evolution
Plants rely on gamete dispersal to ensure the inheritance of their genes. Gene flow, mediated by pollen and seed dispersal, also fosters species' cohesion across space, facilitates population migration, and influences local adaptation. Nothofagus pumilio
C. Soliani, J. Sekely, C. Zamora‐Ballesteros, K. Heer, O. Lepais, V. Mondino, L. Opgenoorth, M. Pastorino, P. Marchelli   +8 more
doaj   +1 more source