Results 121 to 130 of about 1,747,624 (329)

Frequency of Drug Resistance Gene Amplification in Clinical Leishmania Strains

International Journal of Microbiology, 2010
Experimental studies about Leishmania resistance to metal and antifolates have pointed out that gene amplification is one of the main mechanisms of drug detoxification.
C. Mary, F. Faraut, M. Deniau, J. Dereure, K. Aoun, S. Ranque, R. Piarroux   +6 more
doaj   +1 more source

Protein-coding variants implicate novel genes related to lipid homeostasis contributing to body-fat distribution. [PDF]

, 2019
Body-fat distribution is a risk factor for adverse cardiovascular health consequences. We analyzed the association of body-fat distribution, assessed by waist-to-hip ratio adjusted for body mass index, with 228,985 predicted coding and splice site ...
Abecasis, Goncalo, Alam, Dewan S, Alfred, Tamuno, Allison, Matthew, Amouyel, Philippe, Arzumanyan, Zorayr, Auer, Paul L, Balkau, Beverley, Bastarache, Lisa, Bergmann, Sven, Bielak, Lawrence F, Blüher, Matthias, Boehnke, Michael, Boeing, Heiner, Boerwinkle, Eric, Bork-Jensen, Jette, Bottinger, Erwin P, Bowden, Donald W, Brandslund, Ivan, Broer, Linda, Burt, Amber A, Butterworth, Adam S, Böger, Carsten A, Caulfield, Mark J, Cesana, Giancarlo, Chambers, John C, Chasman, Daniel I, Chen, Yii-Der Ida, Chowdhury, Rajiv, Christensen, Cramer, Chu, Audrey Y, Collins, Francis S, Cook, James P, Cox, Amanda J, Crosslin, David S, Danesh, John, de Bakker, Paul IW, Dedoussis, George, Demerath, Ellen W, Dennis, Joe G, Denny, Josh C, Denus, Simon de, Di Angelantonio, Emanuele, Drenos, Fotios, Dubé, Marie-Pierre, Dunning, Alison M, Dörr, Marcus, Easton, Douglas F, Elliott, Paul, Esko, Tõnu, Evangelou, Evangelos, Farmaki, Aliki-Eleni, Feitosa, Mary F, Feng, Shuang, Ferrannini, Ele, Ferrieres, Jean, Fine, Rebecca S, Florez, Jose C, Fornage, Myriam, Fox, Caroline S, Franks, Paul W, Friedrich, Nele, Gan, Wei, Gandin, Ilaria, Gasparini, Paolo, Giedraitis, Vilmantas, Giri, Ayush, Girotto, Giorgia, Gorski, Mathias, Graff, Mariaelisa, Grallert, Harald, Grarup, Niels, Grove, Megan L, Guo, Xiuqing, Gustafsson, Stefan, Haessler, Jeff, Hansen, Torben, Hattersley, Andrew T, Heard-Costa, Nancy L, Highland, Heather M, Justice, Anne E, Karaderi, Tugce, Lempradl, Adelheid, Lo, Ken Sin, Locke, Adam E, Lu, Yingchang, Mahajan, Anubha, Manning, Alisa K, Marouli, Eirini, Medina-Gomez, Carolina, Mudgal, Poorva, Mutsert, Renée de, Ng, Maggie CY, Schurmann, Claudia, Sivapalaratnam, Suthesh, Turcot, Valérie, Vedantam, Sailaja, Willems, Sara M, Winkler, Thomas W, Young, Kristin L   +99 more
core  

Limitations in the Accuracy of Estimates of Blood Group Gene Frequencies [PDF]

, 1957
Alexander S. Wiener
openalex   +1 more source

Purification tags markedly affect self‐aggregation of CPEB3

FEBS Letters, EarlyView.
Although recombinant proteins are used to study protein aggregation in vitro, uncleaved tags can interfere with accurate interpretation. Our findings demonstrate that His₆‐GFP and His₁₂ tags significantly affect liquid droplet and amyloid fibril formation in the intrinsically disordered region (IDR) of mouse cytoplasmic polyadenylation element‐binding ...
Harunobu Saito, Yujin Lee, Motoharu Ueno, Naotaka Sekiyama, Masatomo So, Ayako Furukawa, Kenji Sugase   +6 more
wiley   +1 more source

GENE FREQUENCIES IN TWO BRAZIL-INDIAN TRIBES [PDF]

, 1956
H. Kalmus
openalex   +1 more source

Unlocking the potential of tumor‐derived DNA in urine for cancer detection: methodological challenges and opportunities

Molecular Oncology, EarlyView.
Urine is a rich source of biomarkers for cancer detection. Tumor‐derived material is released into the bloodstream and transported to the urine. Urine can easily be collected from individuals, allowing non‐invasive cancer detection. This review discusses the rationale behind urine‐based cancer detection and its potential for cancer diagnostics ...
Birgit M. M. Wever, Renske D. M. Steenbergen   +1 more
wiley   +1 more source

The mean Frequencies of Blood Group Genes in Sweden with special Regard to the Rh Genes [PDF]

, 1959
Bengt Gunnar Jonsson
openalex   +1 more source

Identification of functional and diverse circulating cancer‐associated fibroblasts in metastatic castration‐naïve prostate cancer patients

Molecular Oncology, EarlyView.
Cancer‐associated fibroblasts (CAFs) promote cancer growth, invasion (metastasis), and drug resistance. Here, we identified functional and diverse circulating CAFs (cCAFs) in patients with metastatic prostate cancer (mPCa). cCAFs were found in higher numbers and were functional and diverse in mPCa patients versus healthy individuals, suggesting their ...
Richell Booijink, Leon W. M. M. Terstappen, Eshwari Dathathri, Khrystany Isebia, Jaco Kraan, John Martens, Ruchi Bansal   +6 more
wiley   +1 more source

FREQUENCY OF HFE GENE MUTATION IN IRON OVERLOAD PATIENTS

Pakistan Armed Forces Medical Journal, 2019
Objective: To determine the frequency of HFE gene mutation in iron overload patients. Study Design: Cross sectional study. Place and Duration of Study: Department of Chemical Pathology and Endocrinology, Armed Forces Institute of Pathology (AFIP ...
Dr. Noreen, Tariq Bin Sharif, Naveed Asif, Hamza Akhtar, Dr. Quratulain, Waqas Hanif   +5 more
doaj  

Surfaceome: a new era in the discovery of immune evasion mechanisms of circulating tumor cells

Molecular Oncology, EarlyView.
In the era of immunotherapies, many patients either do not respond or eventually develop resistance. We propose to pave the way for proteomic analysis of surface‐expressed proteins called surfaceome, of circulating tumor cells. This approach seeks to identify immune evasion mechanisms and discover potential therapeutic targets. Circulating tumor cells (
Doryan Masmoudi, Jérome Vialaret, Christophe Hirtz, Catherine Alix‐Panabières   +3 more
wiley   +1 more source