Results 111 to 120 of about 19,516,845 (337)
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
FREQUENCY OF HFE GENE MUTATION IN IRON OVERLOAD PATIENTS
Pakistan Armed Forces Medical Journal, 2019 Objective: To determine the frequency of HFE gene mutation in iron overload patients. Study Design: Cross sectional study. Place and Duration of Study: Department of Chemical Pathology and Endocrinology, Armed Forces Institute of Pathology (AFIP ...
Dr. Noreen +5 more
doaj +4 more sources
Frequency of haplotypes in TAS2R38 gene (with rare haplotypes*).
Frequency of haplotypes in TAS2R38 gene (with rare haplotypes*).
Dorota Łukasiewicz-Śmietańska (18468786) +7 more
core +1 more source
Translophagy—A potential link between autophagy impairment and translational errors
FEBS Letters, EarlyView.Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk +11 more
wiley +1 more source
Structural and biochemical analysis of a B12 superbinder
FEBS Letters, EarlyView.BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices +3 more
wiley +1 more source
, 2014 Funnel plot of ApoE gene polymorphism and MI risk: A) ε2 allele frequency analysis; B) ε4 allele frequency analysis.
Qiang Zhao (105948) +6 more
core +1 more source
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
Frequency of haplotypes in TAS2R38 gene (without the rare haplotypes) and alleles in CA6 gene.
Frequency of haplotypes in TAS2R38 gene (without the rare haplotypes) and alleles in CA6 gene.
Dorota Łukasiewicz-Śmietańska (18468786) +7 more
core +1 more source
, 2014 Influence analysis of ApoE gene polymorphism and MI risk: A) ε2 allele frequency analysis; B) ε4 allele frequency analysis.
Qiang Zhao (105948) +6 more
core +1 more source
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source