Results 111 to 120 of about 14,201,582 (335)

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

A gene frequency model for QTL mapping using Bayesian inference

Genetics Selection Evolution, 2010
Background Information for mapping of quantitative trait loci (QTL) comes from two sources: linkage disequilibrium (non-random association of allele states) and cosegregation (non-random association of allele origin).
Dekkers Jack CM, Fernando Rohan L, He Wei, Gilbert Helene   +3 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Novel single nucleotide polymorphisms in candidate genes for growth in tilapia ( Oreochromis niloticus )

Revista Brasileira de Zootecnia, 2016
The objective of the present work was to identify and validate single nucleotide variations located in candidate genes to growth traits in tilapia (Oreochromis niloticus). Two transitions were identified in the promoter region of the growth hormone gene (
Breidy Lizeth Cuevas-Rodríguez, Ana María Sifuentes-Rincón, Pascuala Ambriz-Morales, Manuel García-Ulloa, Francisco Javier Valdez-González, Hervey Rodríguez-González   +5 more
doaj   +1 more source

Protein-coding variants implicate novel genes related to lipid homeostasis contributing to body-fat distribution. [PDF]

, 2019
Body-fat distribution is a risk factor for adverse cardiovascular health consequences. We analyzed the association of body-fat distribution, assessed by waist-to-hip ratio adjusted for body mass index, with 228,985 predicted coding and splice site ...
Abecasis, Goncalo, Alam, Dewan S, Alfred, Tamuno, Allison, Matthew, Amouyel, Philippe, Arzumanyan, Zorayr, Auer, Paul L, Balkau, Beverley, Bastarache, Lisa, Bergmann, Sven, Bielak, Lawrence F, Blüher, Matthias, Boehnke, Michael, Boeing, Heiner, Boerwinkle, Eric, Bork-Jensen, Jette, Bottinger, Erwin P, Bowden, Donald W, Brandslund, Ivan, Broer, Linda, Burt, Amber A, Butterworth, Adam S, Böger, Carsten A, Caulfield, Mark J, Cesana, Giancarlo, Chambers, John C, Chasman, Daniel I, Chen, Yii-Der Ida, Chowdhury, Rajiv, Christensen, Cramer, Chu, Audrey Y, Collins, Francis S, Cook, James P, Cox, Amanda J, Crosslin, David S, Danesh, John, de Bakker, Paul IW, Dedoussis, George, Demerath, Ellen W, Dennis, Joe G, Denny, Josh C, Denus, Simon de, Di Angelantonio, Emanuele, Drenos, Fotios, Dubé, Marie-Pierre, Dunning, Alison M, Dörr, Marcus, Easton, Douglas F, Elliott, Paul, Esko, Tõnu, Evangelou, Evangelos, Farmaki, Aliki-Eleni, Feitosa, Mary F, Feng, Shuang, Ferrannini, Ele, Ferrieres, Jean, Fine, Rebecca S, Florez, Jose C, Fornage, Myriam, Fox, Caroline S, Franks, Paul W, Friedrich, Nele, Gan, Wei, Gandin, Ilaria, Gasparini, Paolo, Giedraitis, Vilmantas, Giri, Ayush, Girotto, Giorgia, Gorski, Mathias, Graff, Mariaelisa, Grallert, Harald, Grarup, Niels, Grove, Megan L, Guo, Xiuqing, Gustafsson, Stefan, Haessler, Jeff, Hansen, Torben, Hattersley, Andrew T, Heard-Costa, Nancy L, Highland, Heather M, Justice, Anne E, Karaderi, Tugce, Lempradl, Adelheid, Lo, Ken Sin, Locke, Adam E, Lu, Yingchang, Mahajan, Anubha, Manning, Alisa K, Marouli, Eirini, Medina-Gomez, Carolina, Mudgal, Poorva, Mutsert, Renée de, Ng, Maggie CY, Schurmann, Claudia, Sivapalaratnam, Suthesh, Turcot, Valérie, Vedantam, Sailaja, Willems, Sara M, Winkler, Thomas W, Young, Kristin L   +99 more
core  

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Frequency of Drug Resistance Gene Amplification in Clinical Leishmania Strains

International Journal of Microbiology, 2010
Experimental studies about Leishmania resistance to metal and antifolates have pointed out that gene amplification is one of the main mechanisms of drug detoxification.
C. Mary, F. Faraut, M. Deniau, J. Dereure, K. Aoun, S. Ranque, R. Piarroux   +6 more
doaj   +1 more source

High-frequency Gene Transfer in Pasteurella pseudotuberculosis [PDF]

Journal of General Microbiology, 1971
SUMMARY: A high-frequency donor strain of Pasteurella pseudotuberculosis group A was isolated from a strain which had previously accepted an F'lac episome from Escherichia coli. This donor transferred a variety of genetic markers to P. pseudo-tuberculosis group A recipients.
openaire   +2 more sources