Results 91 to 100 of about 14,201,582 (335)

FREQUENCY OF NRAS AND KRAS GENES IN NEWLY DIAGNOSED ACUTE MYELOID LEUKEMIA PATIENTS

Pakistan Armed Forces Medical Journal, 2020
Objective: To determine the frequency of NRAS and KRAS mutations in newly diagnosed acute myeloid leukemia patients and correlation with their clinicopathological parameters along with prognostic impact. Study Design: Cross-sectional study.
Sidra Barlas, Helen Mary Robert, Rafia Mahmood, Asad Mahmood, Ayesha Khurshid, Saleem Ahmed Khan   +5 more
doaj  

A comparative study of Tam3 and Ac transposition in transgenic tobacco and petunia plants [PDF]

, 1989
Transposition of the Anthirrinum majus Tam3 element and the Zea mays Ac element has been monitored in petunia and tobacco plants. Plant vectors were constructed with the transposable elements cloned into the leader sequence of a marker gene ...
A Day, A Herrmann, A Hoekema, A Hudson, AH Shirsat, B Baker, B Baker, C Martin, C Martin, C O'Reilly, Caius M. T. Rommens, D Inzé, DC Baulcombe, F Sanger, G Ditta, H Sommer, H. John J. Nijkamp, J Gielen, J Paz-Ares, Jacques Hille, JDG Jones, JI Yoder, Jie Gao, JM Goddard, KC Cone, LO Vodkin, M Motto, M-A Grandbastien, MA Sluys Van, Michel A. Haring, NV Fedoroff, P Maliga, P Nevers, P Vlaming De, R Carpenter, RA Jefferson, S Knapp, SL Dellaporta, T Maniatis, Tjeerd Volbeda, U Behrens, WD Sutton   +41 more
core   +4 more sources

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Apolipoproteins AI/B/E gene polymorphism and their plasma levels in patients with coronary artery disease in a tertiary care-center of Eastern India

Indian Heart Journal, 2013
Aim: The present study was designed to investigate whether the three-apolipoprotein (AI, B, E) gene polymorphisms were related to alter their plasma protein levels and hence associated to coronary artery disease (CAD). Methods: We determined distribution
Santanu Biswas, Pradip K. Ghoshal, Bhubaneswar Halder, Kajal Ganguly, Arup DasBiswas, Nripendranath Mandal   +5 more
doaj   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Genomic and Molecular Landscape of DNA Damage Repair Deficiency across The Cancer Genome Atlas [PDF]

, 2018
DNA damage repair (DDR) pathways modulate cancer risk, progression, and therapeutic response. We systematically analyzed somatic alterations to provide a comprehensive view of DDR deficiency across 33 cancer types.
Alvaro, Domenico, Andrew D, Cherniack, Bin, Feng, Bragazzi, MARIA CONSIGLIA, Cardinale, Vincenzo, Casey S, Greene, Chase, Miller, Chen, Wang, Christina, Yau, David A, Wheeler, Denise, Wolf, Eve, Shinbrot, Galen F, Gao, Gaudio, Eugenio, Gordon B, Mills, Gregory P, Way, Hai, Hu, Haoran, Chen, Hui, Shen, Huihui, Fan, Ilya, Shmulevich, Jianfang, Liu, John N, Weinstein, Lawrence A, Donehower, Lei, Li, Li, Ding, Linghua, Wang, Matthew H, Bailey, Michael T, Zimmermann, Mostafa, Karimi, Nyasha, Chambwe, Peilin, Jia, Peter W, Laird, Pora, Kim, Raymond J, Monnat, Rehan, Akbani, Shaojun, Zhang, Theo A, Knijnenburg, Yang, Shen, Yonghong, Xiao, Yuexin, Liu, Zhongming, Zhao   +41 more
core   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Extremely low-frequency electromagnetic field (ELF-EMF) induced alterations in gene expression and cytokine secretion in clear cell renal carcinoma cells

Medycyna Pracy
Background The study aimed to investigate the influence of extremely low-frequency electromagnetic fields (ELF-EMF) on clear cell renal cell carcinoma (ccRCC) by assessing alterations in gene expression and the secretion of cytokines and chemokines ...
Aleksandra Cios, Martyna Ciepielak, Krystyna Lieto, Damian Matak, Sławomir Lewicki, Małgorzata Palusińska, Wanda Stankiewicz, Łukasz Szymański   +7 more
doaj   +1 more source

The infinitely many genes model with horizontal gene transfer

, 2014
The genome of bacterial species is much more flexible than that of eukaryotes. Moreover, the distributed genome hypothesis for bacteria states that the total number of genes present in a bacterial population is greater than the genome of every single ...
Baumdicker, Franz, Pfaffelhuber, Peter
core   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source