Results 271 to 280 of about 1,747,624 (329)

Screening Biomarkers and Risk Factors for COVID-19 Progression in a Border Population Between Brazil-Bolivia. [PDF]

Biomed Eng Comput Biol
Passos-Silva AM, Araújo A, Roca TP, Queiroz JADS, Sgorlon G, Rampazzo RCP, Salcedo JMV, Zuliani JP, Vieira D.   +8 more
europepmc   +1 more source

Possible role of human ribonuclease dicer in the regulation of R loops

FEBS Open Bio, EarlyView.
R loops play an important role in regulating key cellular processes such as replication, transcription, centromere stabilization, or control of telomere length. However, the unscheduled accumulation of R loops can cause many diseases, including cancer, and neurodegenerative or inflammatory disorders. Interestingly, accumulating data indicate a possible
Klaudia Wojcik, Paulina Krzeminska, Anna Kurzynska‐Kokorniak   +2 more
wiley   +1 more source

Immune perturbations in human pancreas lymphatic tissues prior to and after type 1 diabetes onset. [PDF]

Nat Commun
Golden GJ, Wu VH, Hamilton JT, Amses KR, Shapiro MR, Sada Japp A, Liu C, Pampena MB, Kuri-Cervantes L, Knox JJ, Gardner JS, HPAP Consortium, Atkinson MA, Brusko TM, Luning Prak ET, Kaestner KH, Naji A, Betts MR.   +17 more
europepmc   +1 more source

Downregulation of O‐GlcNAcylation enhances etoposide‐induced p53‐mediated apoptosis in HepG2 human liver cancer cells

FEBS Open Bio, EarlyView.
Etoposide, a topoisomerase II inhibitor, reduces O‐GlcNAcylation in HepG2 liver cancer cells. Further inhibition of O‐GlcNAc transferase by OSMI‐1 enhanced etoposide‐induced apoptosis, lowering the IC50 for viability and increasing the EC50 for cytotoxicity.
Jaehoon Lee, Gi‐Bang Koo, Jihye Park, Byung‐Cheol Han, Mijin Kwon, Seung‐Ho Lee   +5 more
wiley   +1 more source

Electrical Stimulation Using a Low-Frequency and Low-Intensity Alternating Current Modulates Type I Procollagen Production and MMP-1 Expression in Dermal Fibroblasts. [PDF]

Ann Dermatol
Kang BM, Ahn JM, Kim J, Paik K, Kim BR, Lee DH, Youn SW, Eom KY, Choi CW.   +8 more
europepmc   +1 more source

On subcellular distribution of the zinc finger 469 protein (ZNF469) and observed discrepancy in the localization of endogenous and overexpressed ZNF469

FEBS Open Bio, EarlyView.
ZNF469 regulates the expression of genes encoding extracellular matrix proteins. Endogenous ZNF469 is predominantly cytoplasmic, while in transfected cells, it forms aggregates reminiscent of biomolecular condensates, located mainly in the nucleus. These condensates exhibit overlapping staining with proteasomes and are also associated with the mitotic ...
Anne Elisabeth Christensen Mellgren, Ileana Cristea, Thomas Stevenson, Endy Spriet, Per Morten Knappskog, Stig Ove Bøe, Harald Kranz, Sushma N. Grellscheid, Eyvind Rødahl   +8 more
wiley   +1 more source

The prevalence of pathogenic variants in the BMPR2 gene in patients with the idiopathic pulmonary arterial hypertension in the Russian population: sequencing data and meta-analysis. [PDF]

Respir Res
Okhrimenko G, Borovikova I, Dankovtseva E, Zamyatin V, Nikulin D, Zobova E, Lyzhenkova A, Danilova A, Osipova N, Minushkina L, Zateyshchikov D, Poptsova M.   +11 more
europepmc   +1 more source

Enhanced discovery of bacterial laccase‐like multicopper oxidase through computer simulation and metagenomic analysis of industrial wastewater

FEBS Open Bio, EarlyView.
We obtained potential bacterial laccase‐like multicopper oxidase (LMCO) sequences through metagenomic sequencing. All sequences exhibited significant differences from known LMCOs in databases. To select the most promising candidates, we performed structure prediction and molecular docking using alphafold2, metal3d and rosetta.
Ting Cui, Ariel Kushmaro, Hana Barak, Anja Poehlein, Rolf Daniel, Hans‐Jürgen Mägert   +5 more
wiley   +1 more source

Molecular characterization and complexity of the immunoglobulin repertoire in the silver-black fox (Vulpes vulpes). [PDF]

BMC Vet Res
Yi X, Qiu Y, Xie P, Wang S, Sun X.
europepmc   +1 more source