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Effect of misspecification of gene frequency on the two-point LOD score

European Journal of Human Genetics, 2001
In this study, we used computer simulation of simple and complex models to ask: (1) What is the penalty in evidence for linkage when the assumed gene frequency is far from the true gene frequency?
Deb K Pal, Martina Durner, M Durner
exaly   +3 more sources

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Mutant gene frequencies in cats of Cyprus

Theoretical and Applied Genetics, 1972
Three areas of the island of Cyprus have been sampled for frequency of nine mutant genes among the domestic cat population. The significance of the observed frequencies are discussed with particular reference to the existence of world-wide clines for O (orange) and t (b) (blotched tabby).
Roy Robinson
exaly   +3 more sources

Estimation of the gene frequency of aceruloplasminemia in Japan

Neurology, 1999
Aceruloplasminemia is a newly recognized autosomal recessive disorder of iron metabolism that causes neurodegeneration of the retina and basal ganglia as well as diabetes mellitus. We screened the serum ceruloplasmin concentrations of 4,990 healthy adult individuals.
H. Miyajima, S. Kohno, Y. Takahashi, O. Yonekawa, T. Kanno   +4 more
semanticscholar   +3 more sources

Frequency Decomposition Based Gene Clustering

, 2015
Gene expressions have been commonly applied to understand the inherent underlying mechanism of known biological processes. Although the microarray gene expressions usually appear aperiodic, with proper signal processing techniques, its periodic components can be easily obtained.
Md. Abdur Rahman 0002, Madhu Chetty, Dieter Bulach, Pramod P. Wangikar   +3 more
openaire   +2 more sources