Results 251 to 260 of about 1,142,696 (310)

Genotoxicity and gene expression modulation associated with the use of DDVP antiparasitic drugs in aquaculture on <i>Danio rerio</i>. [PDF]

Front Vet Sci
Viralkumar A, Singh LS, Iqbal G, Shrivastava V, Barad RR, Mori K, Kumar S.   +6 more
europepmc   +1 more source

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Pathogenicity Analysis and Molecular Characterization of Three <i>Avr</i> Genes in <i>Magnaporthe oryzae</i> Population from Central Jilin Province. [PDF]

Microorganisms
Wang Y, Zhang N, Han R, Lu A, Nan N, Li D, Sun W.   +6 more
europepmc   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Quantifying Epigenetic Changes Induced by Chemical Exposure Using the epi-TK Assay. [PDF]

Bio Protoc
Kuroki S, Yamada H, Odagiri M, Sugiyama KI, Yasui M, Sassa A.   +5 more
europepmc   +1 more source

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source

Laryngeal Transcriptomic Insights into Echolocation Call Frequency Divergence in Closely Related <i>Rhinolophus</i> Species. [PDF]

Biology (Basel)
Miao G, Cong J, Lei J, Quan S, Li J, Li Y, Zhang K, Liu T.   +7 more
europepmc   +1 more source

Elevated Allele Frequency of a Common Germline <i>LAG3</i> Variant Associated with Anemia, Thrombocytopenia and Peripheral Blast Percentage in Acute Myeloid Leukemia. [PDF]

Cancers (Basel)
Seipel K, Shaforostova I, Tarozzi E, Kronig MN, Bacher U, Pabst T.   +5 more
europepmc   +1 more source

Population-Specific Mutational Spectrum of Autosomal Recessive Nonsyndromic Hearing Loss in Croatian Roma: Implications for Clinical Genetics. [PDF]

Genes (Basel)
Kutija Fučkar I, Zajc Petranović M, Martinović Klarić I, Peričić Salihović M, Barać Lauc L.   +4 more
europepmc   +1 more source