Results 231 to 240 of about 14,201,582 (335)

Leukocytes Transcriptome Analysis of Genes Associated with Epilepsy Duration and Age of Onset. [PDF]

Mol Neurobiol
Sarangdhar MA, Zelano J.
europepmc   +1 more source

Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system

FEBS Open Bio, EarlyView.
An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková, Veronika Hovanová, Jiri Damborsky, Erik Sedlák   +3 more
wiley   +1 more source

Mapping the intellectual landscape and emerging trends of retinitis pigmentosa research. [PDF]

Front Med (Lausanne)
Xiao L, Tang LX, Ai M, Yang YJ, Deng Y, Lu J, Zhou YS, Xiong J, Peng Q.   +8 more
europepmc   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Frecuencia de la variante alélica CYP2D6*6 en una muestra de la población cubana

Revista Habanera de Ciencias Médicas
Hilda Roblejo Balbuena, Ileana Rosado Ruiz-Apodaca, Antonio Alejandro Esperón Álvarez, Teresa Collazo Mesa, Lisset Evelyn Fuentes Smith   +4 more
doaj  

CD163 and Tim-4 identify resident intestinal macrophages that are spatially regulated by TGF-β. [PDF]

J Exp Med
Jayaraman V, Prise IE, Kästele V, Tamburrano S, Wemyss K, Bridgeman HM, Daw RH, Strangward P, Sanderson A, Cruickshank SM, Konkel JE, Chew C, Yao C, Anderson CJ, Priller J, McColl B, Munro DAD, Martens L, Scott CL, Guilliams M, Adamson AD, Grainger JR, Shaw TN.   +22 more
europepmc   +1 more source

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

State-dependent promoter switching mediates integrase gene transcription in the integrative and conjugative element ICEKp1 of Klebsiella pneumoniae. [PDF]

Nucleic Acids Res
Liu G, Huang Z, Guan J, Tai C, Shi L, Chao Y, Wang R, Wang K, Ou HY.   +8 more
europepmc   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Temporal and gene-specific dynamics of codon usage evolution in SARS-CoV-2 genomes. [PDF]

BMC Genomics
Błażej P, Mackiewicz D, Mackiewicz P.
europepmc   +1 more source