Singular solutions of the diffusion equation of population genetics [PDF]
, 2007 The forward diffusion equation for gene frequency dynamics is solved subject to the condition that the total probability is conserved at all times. This can lead to solutions developing singular spikes (Dirac delta functions) at the gene frequencies 0 ...
A.J. McKane +19 more
core +2 more sources
Molecular Spectrum of Beta-Globin Mutations in Transfusion-Dependent Patients with Thalassemia in Qazvin Province, Iran [PDF]
Iranian Journal of Medical Sciences, 2009 Background: Beta thalassemia is a common inherited disease,resulting from one or more of 200 different mutations in the betaglobingene. Qazvin province has attracted migrations of severaldifferent populations due to industrialization during the past ...
Mohammad Reza Sarookhani +2 more
doaj
The diversity of a distributed genome in bacterial populations
, 2010 The distributed genome hypothesis states that the set of genes in a population of bacteria is distributed over all individuals that belong to the specific taxon. It implies that certain genes can be gained and lost from generation to generation.
Baumdicker, F. +2 more
core +1 more source
A dynamical model reveals gene co-localizations in nucleus [PDF]
, 2009 Co-localization of networks of genes in the nucleus is thought to play an important role in determining gene expression patterns. Based upon experimental data, we built a dynamical model to test whether pure diffusion could account for the observed co ...
Jing Kang +46 more
core +5 more sources
Frontiers in PharmacologyIntroductionIn collaboration with the Minnesota Hmong community, we have previously discovered significant differences in allele frequencies for key Single Nucleotide Variations (SNVs) within Very Important Pharmacogenes (VIPs) between Hmong and East ...
Boguang Sun +8 more
doaj +1 more source
The pause-initiation limit restricts transcription activation in human cells.
, 2019 Eukaryotic gene transcription is often controlled at the level of RNA polymerase II (Pol II) pausing in the promoter-proximal region. Pausing Pol II limits the frequency of transcription initiation ('pause-initiation limit'), predicting that the pause ...
Cramer, P., Gressel, S., Schwalb, B.
core +1 more source
Improving the efficiency of homologous recombination by chemical and biological approaches in Yarrowia lipolytica. [PDF]
PLoS ONE, 2018 Gene targeting is a challenge in Yarrowia lipolytica (Y. lipolytica) where non-homologous end-joining (NHEJ) is predominant over homologous recombination (HR). To improve the frequency and efficiency of HR in Y.
In-Seung Jang +4 more
doaj +1 more source
Genetic pattern and penetrance of polycystic kidney disease in the Western region of Iraq [PDF]
مجلة جامعة الانبار للعلوم الصرفة, 2012 The aims of this study are to identify the genetic pattern, estimation of gene frequency, penterance, prevalence of PKD, and to furnish an appropriate plan for genetic counselling specific for these families under investigation.
Louay Mohammed Alani
doaj +1 more source
Prevalence of Panton-valentine gene in Staphylococcus aureus isolated from clinical samples and healthy carriers in Gorgan city, north of Iran [PDF]
, 2015 Aim. Staphylococcus aureus (S. aureus) is a nosocomial and community acquired pathogen. S. aureus is a pathogen that causes several types of disease from skin infections to systemic diseases that is because of having several virulence factors such as ...
Ghaemi, E. +3 more
core
Landscape of standing variation for tandem duplications in Drosophila yakuba and Drosophila simulans [PDF]
, 2014 We have used whole genome paired-end Illumina sequence data to identify tandem duplications in 20 isofemale lines of D. yakuba, and 20 isofemale lines of D. simulans and performed genome wide validation with PacBio long molecule sequencing. We identify 1,
Andolfatto, Peter +5 more
core +3 more sources