Influence of gene copy number on self-regulated gene expression [PDF]
Using an analytically solvable stochastic model, we study the properties of a simple genetic circuit consisting of multiple copies of an self-regulating gene. We analyse how the variation in gene copy number and the mutations changing the auto-regulation strength affect the steady-state distribution of protein concentration.
arxiv +1 more source
Study on Radio-Frequency Signal Gene Characteristics From the Perspective of Fractal Theory
Radio frequency signal identification technology is a non-password authentication method based on the physical layer hardware of the device. This paper explores the feature extraction and recognition method based on the gene characteristics of the radio ...
Jingchao Li+4 more
doaj +1 more source
Improving the efficiency of homologous recombination by chemical and biological approaches in Yarrowia lipolytica. [PDF]
Gene targeting is a challenge in Yarrowia lipolytica (Y. lipolytica) where non-homologous end-joining (NHEJ) is predominant over homologous recombination (HR). To improve the frequency and efficiency of HR in Y.
In-Seung Jang+4 more
doaj +1 more source
Random matrix analysis for gene interaction networks in cancer cells [PDF]
Investigations of topological uniqueness of gene interaction networks in cancer cells are essential for understanding this disease. Based on the random matrix theory, we study the distribution of the nearest neighbor level spacings $P(s)$ of interaction matrices for gene networks in human cancer cells.
arxiv +1 more source
Genetic pattern and penetrance of polycystic kidney disease in the Western region of Iraq [PDF]
The aims of this study are to identify the genetic pattern, estimation of gene frequency, penterance, prevalence of PKD, and to furnish an appropriate plan for genetic counselling specific for these families under investigation.
Louay Mohammed Alani
doaj +1 more source
IntroductionIn collaboration with the Minnesota Hmong community, we have previously discovered significant differences in allele frequencies for key Single Nucleotide Variations (SNVs) within Very Important Pharmacogenes (VIPs) between Hmong and East ...
Boguang Sun+8 more
doaj +1 more source
FREQUENCY OF TET2 GENE MUTATION IN MYELOPROLIFERATIVE NEOPLASMS
Objective: To determine the frequency of Ten-Eleven-Translocation-2 (TET2) gene mutation in Myeloproliferative Neoplasms (MPNs) and to generate a local data for evaluation of disease behavior in ten-eleven-translocation-2 positive and negative Patients.
Syed Owais Ali+5 more
doaj
A neutral theory of genome evolution and the frequency distribution of genes
Background The gene composition of bacteria of the same species can differ significantly between isolates. Variability in gene composition can be summarized in terms of gene frequency distributions, in which individual genes are ranked according to the ...
Haegeman Bart, Weitz Joshua S
doaj +1 more source
Single-cell stochastic gene expression kinetics with coupled positive-plus-negative feedback [PDF]
Here we investigate single-cell stochastic gene expression kinetics in a minimal coupled gene circuit with positive-plus-negative feedback. A triphasic stochastic bifurcation upon the increasing ratio of the positive and negative feedback strengths is observed, which reveals a strong synergistic interaction between positive and negative feedback loops.
arxiv +1 more source
A Dynamical Model Reveals Gene Co-Localizations in Nucleus [PDF]
Co-localization of networks of genes in the nucleus is thought to play an important role in determining gene expression patterns. Based upon experimental data, we built a dynamical model to test whether pure diffusion could account for the observed co-localization of genes within a defined subnuclear region.
arxiv +1 more source